Monumental new paper from a great collaboration full of exceptional humans! www.nature.com/articles/s41...

Genetic background sets the trajectory of experimental cancer evolution - Nature

Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...

nature.com

Clear-eyed analysis from @blekhman.bsky.social on the future value and current limitations of AI in science. TLDR: we need to change systems to realize AI's promise blekhman.substack.com/p/why-ai-wil...

It's fantastic to see this finally published! Huge credit to @s-j-aitken.bsky.social and @mstaylor.bsky.social for their determination and creativity on this project, which went in many unexpected directions (with many people along for the ride) and way beyond the initial experimental questions

Sarah Aitken@s-j-aitken.bsky.social · last wk.

🧬NEW PAPER🧬 To what extent is cancer development deterministic? Does the germline genome affect that predictability? Find out in our #StrainDifferences paper @nature.com "Genetic background sets the trajectory of experimental cancer evolution" www.nature.com/articles/s41... 🧵[1/14]

🧬NEW PAPER🧬 To what extent is cancer development deterministic? Does the germline genome affect that predictability? Find out in our #StrainDifferences paper @nature.com "Genetic background sets the trajectory of experimental cancer evolution" www.nature.com/articles/s41... 🧵[1/14]

Genetic background sets the trajectory of experimental cancer evolution - Nature

Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...

nature.com

Simons Graduate Fellowships in #Ecology and #Evolution #science #scienceSky #evoSky www.simonsfoundation.org/grant/simons...

Simons Graduate Fellowships in Ecology and Evolution

The purpose of these awards is to provide support for students entering U.S.-based Ph.D. programs with a plan to perform research in ecology and evolution. While we will consider all projects in ecolo...

simonsfoundation.org

Friday was my last day at NHGRI. After 10 wonderful years, my lab is headed to Johns Hopkins University genomeinformatics.github.io/movingday/

Look at the women at NASA. They are the ones pushing the boundaries of science, solving problems most people can’t even understand, and carrying this country forward, while our politicians right now posture and stumble through talking points. And they are doing it all with joy.👇

Genome Biology and Evolution launches a new virtual collection on "Conservation Genomics" Read our accompanying Highlight: "Genome Science at the Forefront of Biodiversity's Greatest Challenges" 🔗 buff.ly/qBGcsG7 Access the new virtual collection 🔗 buff.ly/VxXZUKv #genome #evolution #congen

Saddened to hear of Phil Bourne's death. I first encountered him as chair of ISMB 2000 in San Diego at my first ever computational biology conference. He always pushed for open science and always tried to make things better. In both he made a positive difference news.virginia.edu/content/memo...

In memoriam: Philip Bourne, founding dean of the School of Data Science

The leader, who propelled the school from a concept to national recognition, had battled mesothelioma.

news.virginia.edu

Crushed to hear of Mark Batzer’s passing. He was the Boyd Professor at Louisiana State University. His influential research revealed how mobile elements shape the genomes of humans & other mammals. Mark’s personality, generosity & positivity were larger than life. He lifted everyone up. HUGE loss 💔

Currently dorking out over this graph about child mortality with my brother. Just mind boggling to take in.

My lab at hiring! - we have TWO postdoc positions (one computational, one wet lab focussed) at Yale @yaleschoolofmed.bsky.social, working closely with our group members at University of Cambridge, UK @cambridgeuni.bsky.social Please help to spread the word! Adverts with full details below ⬇️

Celebrating all of the amazing women in science I've had as mentors, role models, colleagues and friends 🧬👩‍💻🧪

A phenomenal effort to bring this together with so many interesting aspects of how genetic background influences cancer development. I'm honoured to have been part of this project!

Sarah Aitken@s-j-aitken.bsky.social · 2y ago

🌟NEW PREPRINT ALERT!🌟 We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution” www.biorxiv.org/content/10.1... 🧵[1/12]

🌟NEW PREPRINT ALERT!🌟 We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution” www.biorxiv.org/content/10.1... 🧵[1/12]

Genetic background sets the trajectory of cancer evolution

Human cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans,...

biorxiv.org

Associate Professor / Professor of Evolutionary Genomics www.jobs.cam.ac.uk/job/49389/

Abstract submissions are still open for the CSHL Network Biology meeting in March 11 - 15 2025 (abstract deadline: Jan 10). A large fraction of talks will be selected from the abstracts. On behalf of the organizers, we look forward to welcoming you there. meetings.cshl.edu/meetings.asp...

I’ve just read this pre-print and it’s fantastic. A conserved element with no endogenous enhancer activity is nonetheless necessary and sufficient for extreme long range enhancer action. Recommend to anyone interested in gene regulation

Axel Visel@axelvisel.bsky.social · 2y ago

REX - a mammalian "range extender" element that can turn short-distance enhancers into long-distance enhancers. New preprint from a collaboration led by Grace Bower and Evgeny Kvon. doi.org/10.1101/2024...

This looks like a great meeting! In a great place too

Wendy Bickmore@wbickmor.bsky.social · 2y ago

Interested in difficult to access parts of genetics, cellular & structural biology? Join us in Edinburgh 2-4th April 2025 for "Hidden Cell, Dark Genome" Regulation in the dark genome Uncharted proteins, RNA complexity Atomic structures at cellular scale Cell diversity www.ed.ac.uk/c/hidden-cel...

The events of this week suggest that the excitement and hype around AI in science won’t be dying down anytime soon

8/tl;dr: In most situations, it is to the author's maximal benefit to license their manuscripts thusly: preprints: any CC license journal publication: CC BY only 🧪 #AcademicSky

Celebrate #DNADay by reading the comic (and scientifically accurate 🧪) adventures from Cell Town, home of Pol, Hely, Topy, and the Repair Squad as they set out on another round of cell division! drive.google.com/drive/folder...

The use of the phrase “ancestry-specific variant” is increasing, particularly to describe rare Single-nucleotide variants (SNVs). But these alleles are not ancestry-specific. They have not yet been found elsewhere, but they will be. 1/n

At the forefront of research involving long-read sequence data, JAX's @christinebeck.bsky.social & Peter Audano discuss how adjustments to the technical and analytical infrastructure are needed. Read more in their recent Genome Research paper 🧪🤝🖥️ 🧬 : www.jax.org/news-and-ins...

Improving whole genome sequence data analyses

Christine Beck and Peter Audano are at the forefront of research involving long-read sequence data. They are particularly interested in structural variants, where segments of the genome are deleted, i...

jax.org