NEW PRC PAPER 🚨: The Jensen lab discovered that disrupting synaptic vesicle recycling via AAK1, Dnm1, and Dnm3 targets chronic itch at its source. Amazing work @pazduran.bsky.social @tonelloraquel.bsky.social and the team! www.frontiersin.org/journals/mol...

Frontiers | The contribution of endocytic mediators to itch transmission

IntroductionChronic itch is a major burden, impacting the quality of life for one in four adults, and is closely associated with increased levels of anxiety,...

frontiersin.org

NEW PRC PAPER 🚨: The Jensen lab discovered that the human itch receptor MrGPRX1 traffics to the endosomal network, where it continues to signal and drive TRPV1 sensitization. Congratulations to first author @pazduran.bsky.social and the whole team! www.frontiersin.org/journals/mol...

Frontiers | Endosomal MrGPRX1 signaling sensitizes TRPV1 to enhance itch

G protein-coupled receptors (GPCRs) and TRPV (transient receptor potential vanilloid) channels are crucial for signal transduction in physiological processes...

frontiersin.org

NEW PRC PAPER 🚨 from Nestor Jimenez-Vargas and the Bunnett Lab reveals how elevated proteases and histamine drive IBS visceral pain, showing that a prolonged intracellular PAR2 receptor signaling loop keeps the H1 receptor active to continuously amplify and maintain pain. gut.bmj.com/content/earl...

Amazing work from @tonelloraquel.bsky.social!

Raquel Tonello@tonelloraquel.bsky.social · 2mo ago

📣Excited to share our new preprint! We identify synaptic vesicle endocytosis in nociceptors as a key driver of ongoing pain, and show that LNP‑delivered CRISPR/dCas9 repression of this pathway produces durable analgesia across multiple pain models. www.biorxiv.org/content/10.6...

Amazing day so far at the PRC symposium! So much exciting science from our research community and awesome keynote speakers. @karapedsgastrodoc.bsky.social @jimr-1.bsky.social @sarahanajjar.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social

In a new study, researchers describe a bacterial enzyme that synthesizes DNA without a nucleic acid template, using its own structure as a guide. Learn more on #DNADay: https://scim.ag/3OEc2RV

Very proud of our group’s showing at #USASP2026! Thank you to the organizers of this fantastic meeting! @usasp.bsky.social @karapedsgastrodoc.bsky.social @sdavidson.bsky.social @sarahanajjar.bsky.social @yylab.bsky.social @goinsyeah.bsky.social @pazduran.bsky.social @keylinesc.bsky.social

Please visit our posters today at #USASP! @karapedsgastrodoc.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @pazduran.bsky.social

We are thrilled to be at USASP in Philadelphia! Looking forward to a week of great science. @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social @sdavidson.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @mariafialho.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social

NEW PRC PREPRINT 🚨 The Jensen Lab presents a new therapeutic target for itch: Blocking AAK1 and Dynamin in GRP neurons reduces scratching without behavioral side effects. buff.ly/rpfcj90 @tonelloraquel.bsky.social @pazduran.bsky.social

In this week’s #PAIN Featured Image, Gomez et al. describe how the SARS-CoV-2 nucleocapsid (N) protein enhances pathological pain through NaV1.7 modulation. Learn more at bit.ly/4piitaH

Huge thanks to everyone who joined the #PRC Lunch at #SfN — inspiring conversations and incredible research collaborations emerged! 🙌🧠 #PRCmembers #SfN #SanDiego #circleJLabs @sfn.org @sdavidson.bsky.social @pazduran.bsky.social @elisadamo.bsky.social

Excited to share my first senior author paper in Pain! 🎉 We identify Synaptojanin 1 & Endophilin A1 as key endocytic mediators of nociception. Silencing them blocks spinal synaptic transmission and relieves pain in cancer & postoperative models, without affecting normal behavior. buff.ly/caKMGY3

Check out articles like “Pharmacologically enabling the degradation of NaV1.8 channels to reduce neuropathic pain” by Martin et al. in #PAIN bit.ly/3YxTyUV

Bavencoffe et al. find that hyperexcitability in nociceptor somata isolated from ganglia innervating painful and nonpainful regions suggests new functions for widespread, ongoing nociceptor activity. Learn more in #PAIN bit.ly/3G4Y5rB

Check out articles like “Visual exposure to green light therapy reduces knee joint pain and alters the lipidome in osteoarthritic rats” by O’Brien et al. in #PAIN bit.ly/3S2xpe3

PRC Highlight: Congrats to @pazduran.bsky.social for "Best Poster Presentation Finalist in Basic Science" Titled "Compartmentalized Signaling Of Mas-related G-protein Coupled Receptor X1 (MrGPRX1) And Transient Receptor Potential Vanilloid (TRPV) Channels In Pain And Itch Pathways"👏 #USASP_2025

Amazing talk by @tedpricethepainguy.bsky.social on progress in our understanding of pain mechanisms using human DRG and spinal cord. Really cool data on spinal projection neurons in human spinal cord. This is quite amazing!

Congrats to all the poster award winners at #usasp2025! Very proud of my friend Paz Duran who won an award for her amazing work!

Amazing times with @nyupainresearch.bsky.social at the @usasp.bsky.social meeting. Congratulations to all our post docs including @pazduran.bsky.social @sarahanajjar.bsky.social for their amazing presentations! @nyupainresearch.bsky.social @newyorkuniversity.bsky.social

Kicked off the USASP meeting last night with a mega pretzel at the NYU Pain Research Center dinner. Great start to a great week! #USASP2025 #PainResearch #NYUPRC #NetworkingAndPretzels

HOWZAT!! Amazing paper 🤩 Targeted Ganglion Delivery of CaV2.2-Mediated Peptide by DNA Nanoflowers for Relieving Myocardial Infarction and Neuropathic Pain | ACS Nano pubs.acs.org/doi/10.1021/... Thrilled they used our peptide CBD3 (PMID:21642979), from CRMP2, & independently replicated our data 🎉

Targeted Ganglion Delivery of CaV2.2-Mediated Peptide by DNA Nanoflowers for Relieving Myocardial Infarction and Neuropathic Pain

N-type calcium channel (CaV2.2) protein contributes to neuronal excitability and overactivation in sympathetic ganglion (SG) following myocardial infarction (MI), thereby easily triggering cardiac rem...

pubs.acs.org

CaV1.3 channels are vital for dopamine neuron function. We found that mutant LRRK2 (G2019S) enhances their activity via CaVβ3 phosphorylation, a potential key factor in Parkinson's disease. #neuroscience #ionchannels #ParkinsonsDisease #LRRK2 #CaV1.3 www.mdpi.com/1422-0067/26...

NaV1.8/NaV1.9 double knockout mice show their combined role in pain signaling & altered gene expression in DRG neurons. Valuable for studying human pain mutations #ionchannels #pain #neuroscience

BOOM! Human DRG patch-seq with Nav1.8 and Nav1.7 upregulation associated with a history pain in organ donors. www.biorxiv.org/content/10.1... Great stuff from the #PRECISIONPain Center at WashU led by @robgereau.bsky.social

Human sensory neurons exhibit cell-type-specific, pain-associated differences in intrinsic excitability and expression of SCN9A and SCN10A

Despite the prevalence of chronic pain, the approval of novel, non-opioid therapeutics has been slow. A major translational challenge in analgesic development is the difference in gene expression and ...

biorxiv.org

PRC Highlight: @nyupainresearch.bsky.social Dr. Steve Davidson was featured in The New York Times- offering his insights on a BMJ review that examined studies on non-surgical, interventional treatments for low back pain nytimes.com/2025/03/18/w... #nyuniversity #NYUDental #NinaAgrawal @nytimes.com

Most Treatments for Lower Back Pain Don’t Really Work, Study Finds

Researchers looked at 56 treatments for acute and chronic pain. Few of them were effective.

nytimes.com

PRC Highlight: The Jensen Lab is making strides in understanding diseases at the molecular level — paving the way for #future breakthroughs in #oral health and beyond #NYUDentistry #nyuniversity #Jensenlab #3minutemondays

"3-Minute Mondays!": The Jensen Lab

March 17, 2025In this episode of "3-Minute Mondays!" we're diving into the cutting-edge research happening at the Jensen Lab at NYU College of Dentistry. Wit...

youtube.com

Detailed characterization of VGSCs (Nav1.7, 1.8, 1.9) in pain-sensing neurons. Reveals new insights into their roles in action potential generation and pain disorders #painresearch #ionchannels

🔬We study the dorsal root ganglion (DRG), which is a cluster of cells located just outside of the spinal cord. The DRG routes pain signals from the periphery to the central nervous system. #FluorescenceFriday #sciart #neuroart

@nyupainresearch.bsky.social Shoutout 📢 to The NYU Molecular Pathobiology for #hosting an amazing tea time #Mardi #Gras style! #Brazil #Zamba #Turnupthursdays #Happymardigras 🪅🎉🎊🪩💃🕺🏼 #NYUDental #newyorkuniversity