Great new review article from Ru-Rong Ji, Temugin Berta, and colleagues, on neuron-glia interactions in pain! Microglia, astrocytes, and satellite glial cells actively shape pain by driving neuroinflammation, sensitizing neurons, and remodeling pain circuits. journals.physiology.org/doi/full/10....

NEW PRC PAPER 🚨: The Jensen lab discovered that disrupting synaptic vesicle recycling via AAK1, Dnm1, and Dnm3 targets chronic itch at its source. Amazing work @pazduran.bsky.social @tonelloraquel.bsky.social and the team! www.frontiersin.org/journals/mol...

Frontiers | The contribution of endocytic mediators to itch transmission

IntroductionChronic itch is a major burden, impacting the quality of life for one in four adults, and is closely associated with increased levels of anxiety,...

frontiersin.org

NEW PRC PAPER 🚨: The Bunnett lab identified Neuropilin-1 (NRP1) as a key mediator of NGF signaling driving oral cancer pain. Targeting NRP1 disrupts NGF/TrkA signaling, reduces nociceptor sensitization, and alleviates pain without directly blocking NGF! buff.ly/NmyrTLy

📣Excited to share our new preprint! We identify synaptic vesicle endocytosis in nociceptors as a key driver of ongoing pain, and show that LNP‑delivered CRISPR/dCas9 repression of this pathway produces durable analgesia across multiple pain models. www.biorxiv.org/content/10.6...

Targeting Synaptic Vesicle Endocytosis in Nociceptors Provides Sustained Pain Relief

Endocytosis replenishes synaptic vesicle (SV) pools that are required for persistent transmission of chronic pain signals within nociceptive spinal circuits. The nociceptor-specific contribution of SV...

biorxiv.org

Amazing day so far at the PRC symposium! So much exciting science from our research community and awesome keynote speakers. @karapedsgastrodoc.bsky.social @jimr-1.bsky.social @sarahanajjar.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social

We are thrilled to bring together the NYU pain research community at our symposium tomorrow! Looking forward to a day of exciting science, connection, and collaboration.

Amazing opportunity to work with Dr. Gomez!

Kim Gomez@kimgmz6.bsky.social · 5mo ago

Excited (and a little emotional!) to share that I’m hiring my very first postdoc 🥹✨ This lab has been a dream in the making, and I can’t wait to welcome someone to grow, discover, and build something meaningful together. tamus.wd1.myworkdayjobs.com/TAMU_Externa...

Very proud of our group’s showing at #USASP2026! Thank you to the organizers of this fantastic meeting! @usasp.bsky.social @karapedsgastrodoc.bsky.social @sdavidson.bsky.social @sarahanajjar.bsky.social @yylab.bsky.social @goinsyeah.bsky.social @pazduran.bsky.social @keylinesc.bsky.social

Please visit our posters today at #USASP! @karapedsgastrodoc.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @pazduran.bsky.social

We are thrilled to be at USASP in Philadelphia! Looking forward to a week of great science. @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social @sdavidson.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @mariafialho.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social

NEW PRC PAPER 🚨 This study led by @mariafialho.bsky.social from the Bunnett Lab reveals that tryptase from mast cells activates PAR2 on sensory neurons, sustaining painful symptoms induced by an aromatase inhibitor. buff.ly/lVAgUgO @tonelloraquel.bsky.social @karapedsgastrodoc.bsky.social

NEW PRC PREPRINT 🚨 The Jensen Lab presents a new therapeutic target for itch: Blocking AAK1 and Dynamin in GRP neurons reduces scratching without behavioral side effects. buff.ly/rpfcj90 @tonelloraquel.bsky.social @pazduran.bsky.social

We had the honor of hosting Prof Jose Moron-Concepcion from @washumedicine.bsky.social yesterday! He gave a fantastic seminar on novel therapeutic approaches to prevent pain-induced opioid escalation and fentanyl overdoses. @linyhung.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social

📢🔬Check out our latest study on the specific role of endocytic mediators in pain-related synaptic transmission, now out in PAIN. @mariafialho.bsky.social #PainResearch #Neuroscience #SynapticTransmission

PAIN@painthejournal.bsky.social · 10mo ago

Fialho et al. find that synaptojanin 1, endophilin A1, dynamin 1, and adaptor-associated protein kinase-1 mediate synaptic vesicle recycling and neurotransmission in nociceptive circuits in the spinal cord. Learn more in #PAIN bit.ly/3WIf08B

NYU Pain Research Center is expanding! 💥 Seeking brilliant minds (Assistant or Associate Professor, tenure track) to explore chronic pain mechanisms & therapies. Join our mission to transform pain research. Apply now! 🧠✨ #Research #AcademicJobs apply.interfolio.com/176454

🎉 Join us for the 1st NYC Area Pain Research Meet-Up! 🗓 Fri, Dec 5 | 3–6 PM 📍 NYU Pain Research Center, 433 1st Ave Don’t miss Dr. Steve Davidson’s keynote: “Humanizing Pain Neurobiology for Translational Gain” — plus great company & treats! See you there! 💫 #PainResearch #NYCScience #Neurobiology

Excited to share my first senior author paper in Pain! 🎉 We identify Synaptojanin 1 & Endophilin A1 as key endocytic mediators of nociception. Silencing them blocks spinal synaptic transmission and relieves pain in cancer & postoperative models, without affecting normal behavior. buff.ly/caKMGY3

PRC PRIMED! Thank you to @rachelepol.bsky.social for presenting Nanomedicine for Pain: Towards translation through advanced materials, manufacturing and in vitro strategies! Huge round of applause 👏to @linyhung.bsky.social & @tonelloraquel.bsky.social for being amazing hosts! #PinkertonLab #RachelP

PRC PRIMED! #First event of the #year featuring a talk by #Dr. Kehinde Mary Taiwo, a Postdoctoral Fellow in #Dr. Candie Paulsen's lab at #Yale #University! @nyupainresearch.bsky.social #NYUDentistry #NewYorkUniversity

A non-opioid alternative in the treatment of chronic pain! Chloe J. Peach @tonelloraquel.bsky.social & team discover inhibition of Neuropilin-1 suppresses NGF-evoked pain in preclinical models: https://www.jci.org/articles/view/183873

@tedpricethepainguy.bsky.social @utdpaincenter.bsky.social Great visit today from Dr. Ted Price! Thank you for wowing us with your team’s exciting data on human DRG tissue, very inspiring and insightful seminar! #painresearch #dorsalrootganglia #humanDRG #nyudental #nyuniversity #nyupainresearch

I'm excited to share our groundbreaking findings on Neuripilin-1 and its role in NGF/TrkA pain signaling.

NYU Pain Research Center@nyupainresearch.bsky.social · 2y ago

Neuropilin-1 (NRP1) is a co-receptor for NGF/TrkA pain signaling. Inhibiting NRP1 can reduce nociceptor activation and NGF-related pain. This important finding by the Bunnett lab and colleagues could lead to a non-opioid alternative for chronic pain treatment. www.jci.org/articles/vie...

Congrats to the whole team for the paper published in Gastroenterology this week! 🎉🧠🌟 #gutserotonin #depression #anxiety #antidepressants @tonelloraquel.bsky.social @danielxjuarez.bsky.social @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social 👉 www.gastrojournal.org/article/S001...