Ashley Alexander

@peachypotato.bsky.social

Postdoctoral researcher University of Zurich Kümmerli Lab Microbiology, ecology, and evolution

I’m looking to hire an NIH funded postdoc to join our lab here at Davis (please RT). Ongoing areas of interest include: 1) polygenic signals of selection from time series, ARGs, GWAS, etc 2) The interpretation of GWAS, polygenic scores, & sources of confounding

🔔 New preprint from our lab: how does the chemical composition of infection-like environments shape how costly (or not) antibiotic resistance mutations are? We find that efflux pump regulator mutants can have a selective advantage in synthetic human urine + identify likely component driving this.

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 5d ago

Fitness costs of antibiotic resistance mutations in rich media do not reliably predict those in infection-like environments https://www.biorxiv.org/content/10.64898/2026.09.08.750013v1

This job ad is now live! Please share or apply here: jobs.montana.edu/postings/52780 Screening of applicants begins Sept 15, 2026 #MicroSky #PhageSky #ScienceJobs

Postdoctoral Researcher - Lyme Disease Bacteriophage Biology

The Secor Lab seeks a postdoctoral researcher to investigate bacteriophage biology in the Lyme disease spirochete Borrelia burgdorferi. The successful candidate will help define how phiBB-1 controls h...

jobs.montana.edu

Patrick R. Secor@prsecor.bsky.social · 3w ago

I’ll soon be #Hiring a postdoc to join the Secor Lab at Montana State University. This NIH-funded position will investigate phage biology in Lyme disease spirochetes. The official ad will be available soon. Please share with anyone who might be interested! #MicroSky #PhageSky 🔬🦠🧪🧫

An engorged tick with fluorescent bacteria in its midgut

Imagine being talented and beautiful and rich and famous and still the most noteworthy thing about you is how good a person you are.

A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

The Library is devastated to learn of the passing of Dolly Parton, a music legend and titan of children's literacy. Her Imagination Library program has earned multiple Library Literacy Awards and, in 2018, she visited us to donate its 100 millionth book to our collection and host a story time. 🦋❤️

Dolly Parton reads to children in the Library’s Great Hall in 2018. Photo by Shawn Miller.

Officially recruiting postdocs at GW. If you are interested in genetic novelty, structural variation, or evo genetics please get in touch! We have data sets on mulitple organisms with large population sizes (Drosophila, Megalonaias nervosa) and species in decline (fireflies, mussels, elephants).

Conference season is here, and I'll be at #ASMicrobe! Come check out some of my latest results on the honey bee queen microbiome. I'd also love to chat about other ongoing projects on social bee multi-kingdom microbiomes, potential collaborations, or opportunities to join the Caesar Lab at OU : )

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GOOD NEWS! Researchers at Stanford University have developed a UNIVERSAL vaccine known as GLA-3M-052-LS+OVA, that protects against a wide range of respiratory viruses, bacteria AND even allergens. The vaccine is delivered intranasally AND provides broad protection in the lungs for several MONTHS.

Goodbye to seasonal viruses as we know them: the first universal vaccine against respiratory infections and allergies is now closer than ever

Scientists are getting closer to a universal nasal vaccine that could protect against respiratory viruses, bacteria and even allergies

ecoticias.com

This definitely forbidden gummy is in fact a moth larva of genus Olona (possibly Olona zolotuhini). It's *normal* to want to know what flavor it is, but the answer, unfortunately is "pain". Most species in this family are covered in tiny stinging spines connected to poison glands. (📷: Janice Ang)

1/35 New preprint! We show that obligate multicellularity removes fundamental population genetic barriers to multicellular adaptation. Even a brief unicellular phase can dramatically constrain the evolution of beneficial multicellular traits. www.biorxiv.org/content/10.6...

Obligate multicellularity circumvents population genetic barriers to collective-level adaptation

Complex multicellularity has evolved in just five lineages (animals, plants, brown algae, red algae, and fungi) and in each case, these organisms develop clonally and are obligately multicellular. While prior work has shown that clonal development plays a critical role in the evolution of complex multicellularity, none has disentangled this from the impact of obligate vs facultative multicellular life cycles. Here we use experimental evolution with engineered snowflake yeast ( Saccharomyces cerevisiae ) to directly test how life cycle structure affects multicellular adaptation. We created isogenic strains capable of switching between unicellular and clonal multicellular phases, then evolved populations for 192 days under obligately multicellular, facultatively multicellular, and obligately unicellular regimes. Obligately multicellular populations rapidly evolved larger size, primarily driven by a whole genome duplication, in all five replicates. Facultative populations showed dramatically constrained evolution, with tetraploidy evolving in only 2/10 facultative populations despite experiments demonstrating that it is strongly beneficial across the full life cycle. Mathematical modeling reveals the mechanistic basis for this constraint: facultative life cycles create establishment barriers through two population genetic effects. Group formation dramatically reduces the number of units of selection, making beneficial multicellular mutations vulnerable to drift. This asymmetry in population size between life cycle phases also allows cell-level selection to overpower group-level selection, eliminating mutations that provide group-level benefits but carry cell-level costs. These findings demonstrate that obligate multicellularity circumvents fundamental population genetic barriers to collective-level adaptation, helping explain why complex multicellularity has evolved exclusively in obligately multicellular lineages, and suggesting similar constraints may operate in other evolutionary transitions in individuality. ### Competing Interest Statement The authors have declared no competing interest. U.S. National Science Foundation, https://ror.org/021nxhr62, DEB-1845363 Howard Hughes Medical Institute Gilliam Fellowship National Science Foundation Graduate Research Fellowship

biorxiv.org