Check out our new preprint deciphering SlyB structural role for membrane homeostasis during Yersinia pestis infection ! 👇🏻

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 3mo ago

Yersinia pestis lipoprotein SlyB promotes plague pathogenesis via envelope stress tolerance https://www.biorxiv.org/content/10.64898/2026.06.08.730324v1

Pour chaque vie, la science agit. Le Pasteurdon, c’est maintenant ! Soutenez la recherche et celles et ceux qui la font avancer ↘️ pasteurdon.fr #Pasteurdon

Happy to share that the paper describing Autocycler is now 100% up: doi.org/10.1093/bioi... (1/3)

Autocycler: long-read consensus assembly for bacterial genomes

AbstractMotivation. Long-read sequencing enables complete bacterial genome assemblies, but individual assemblers are imperfect and often produce sequence-l

doi.org

💊 🧬 Insightful dive into in-host bacterial evolution under antimicrobial pressure, a work from @csavin.bsky.social and @pierrelebury.bsky.social in our lab at @pasteur.fr

Institut Pasteur | 130 years of biomedical research@pasteur.fr · last yr.

🦠 14 years, one patient, one superbug @yersiniaunit.bsky.social scientists tracked Yersinia enterocolitica mutations as it developed antibiotic resistance over 14 years. Unprecedented view of bacterial evolution under treatment pressure 💊  pubmed.ncbi.nlm.nih.gov/40595576/ #AMR #yersinia

Great collaboration with @csavin.bsky.social at @yersiniaunit.bsky.social in @pasteur.fr, as well as @julmini.bsky.social @chrudetours.bsky.social @univparissaclay.bsky.social @cea.fr @ap-hp.bsky.social 📖 Out in @natcomms.nature.com @natureportfolio.nature.com 👇 www.nature.com/articles/s41...

Institut Pasteur | 130 years of biomedical research@pasteur.fr · last yr.

🦠 14 years, one patient, one superbug @yersiniaunit.bsky.social scientists tracked Yersinia enterocolitica mutations as it developed antibiotic resistance over 14 years. Unprecedented view of bacterial evolution under treatment pressure 💊  pubmed.ncbi.nlm.nih.gov/40595576/ #AMR #yersinia

1/8 - New in @natcomms.nature.com ! ☣️ Meet Yersinia enterocolitica (Ye) — a lesser-known but still dangerous cousin of Yersinia pestis. We uncover how this invasive pathogen can survive and adapt for 14 years inside a human host under constant antibiotic pressure 👇 www.nature.com/articles/s41...

In-host evolution of Yersinia enterocolitica during a chronic human infection - Nature Communications

This study documents the evolution of antibiotic resistance and major growth defects in Yersinia enterocolitica in a patient over 14 years, revealing genetic changes that shed light on bacterial adapt...

nature.com

Very clear explanation by @alicelebreton.bsky.social of our article about plague virulence reduction, in Le Monde (in French)!

Alice Lebreton@alicelebreton.bsky.social · last yr.

Après que la peste a tout dévasté sur son passage, que devient-elle? Lors de chacune des trois pandémies historiques, un même mécanisme a conduit à la mise en sourdine de sa virulence, ce qui favoriserait sa persistence dans des populations de rongeurs fragmentées. www.lemonde.fr/sciences/art...

#NatMicroPicks The plague virulence! 💀🦠 During plague epidemics, virulence gene pla in Yersinia pestis often becomes depleted, which reduces the pathogen's lethality and may help it survive in less susceptible hosts when transmission conditions worsen. #MicroSky www.science.org/doi/10.1126/...

Attenuation of virulence in Yersinia pestis across three plague pandemics

Yersinia pestis has spilled over from wild rodent reservoirs to commensal rodents and humans, causing three historically recorded pandemics. Depletion in the copy number of the plasmid-encoded virulen...

science.org

🦠 The plague bacillus became less virulent, extending the duration of two major pandemics. @yersiniaunit.bsky.social @pierrelebury.bsky.social @mcmasteruniversity.bsky.social @ravneetksidhu.bsky.social

The plague bacillus became less virulent, prolonging the duration of two major pandemics

Scientists at the Institut Pasteur and McMaster University have discovered that the evolution of a gene in the bacterium that causes bubonic plague, Yersinia pestis, may have prolonged the duration of...

pasteur.fr

Picking up our publication on Black Death and plague pandemics: here are interesting historical thoughs about the well known but deceptive (not so) medieval plague doctor costume

The Fake History Hunter@fakehistoryhunter.net · last yr.

There is some news about the Black Death... are we taking bets on how the media is going to illustrate it? .....

Our work on the facial skin microbiome of non-human primates is out in mSystems! We show there is no close relative of Cutibacterium on the faces of gorillas and chimps at the Lincoln Park Zoo, furthering the mysterious origin of the dominant human skin colonizer. journals.asm.org/doi/10.1128/...

The microbiome of the human facial skin is unique compared to that of other hominids | mSystems

Understanding how and why human skin bacteria differ from our closest animal relatives provides crucial insights into human evolution and health. While we have known that human facial skin hosts disti...

journals.asm.org

IIDR researchers have discovered that a single gene in Yersinia pestis — the bacteria that causes bubonic #plague — was responsible for keeping pandemics like the Black Death burning for hundreds of years. Learn more about this evolutionary phenomenon in our all-new explainer video. #IDSky

Two great papers in @science.org this month on the #evolution of #vector-borne #pathogens 1 #Yersinia pestis attenuates virulence over 3 pandemics 2 Ancient #Borrelia genomes trace the rise of louse-borne relapsing fever Fascinating reads (links below)

New in 𝘚𝘊𝘐𝘌𝘕𝘊𝘌: Plague Plays the Long Game As plague pandemics decimated rodent populations, 𝘠𝘦𝘳𝘴𝘪𝘯𝘪𝘢 𝘱𝘦𝘴𝘵𝘪𝘴 adapted Virulence gene 𝘱𝘭𝘢 lost late in outbreaks ➡️ strains with reduced lethality ➡️ pathogen can persist, spread across highly fragmented host networks www.science.org/doi/10.1126/...

1/12 - New in @science.org ! ☠️ Curious of what happened to Yersinia pestis, the bacterium responsible for the Black Death, throughout plague pandemics? Check out our new study 👇 www.science.org/doi/10.1126/...

Attenuation of virulence in Yersinia pestis across three plague pandemics

Yersinia pestis has spilled over from wild rodent reservoirs to commensal rodents and humans, causing three historically recorded pandemics. Depletion in the copy number of the plasmid-encoded virulen...

science.org

White smoke, we have a new pope and also 16 new anti-phages systems in sedentary integrons (SCIs) ! In collaboration with the Rocha lab, we show in our new paper that cassettes of these large platforms encode many known anti-phage defenses, and uncovered 16 new ones. www.science.org/doi/10.1126/...

Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems

Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...

science.org

Habemus paper! Our story on integron-encoded anti-phage defenses is now out in @science.org! 16 new systems, small versions of known ones, and a lot more in this highly-collaborative study. Many thanks to everyone involved, especially my supervisor @epcrocha.bsky.social bsky.app/profile/bapt...

Baptiste Darracq@baptistedarracq.bsky.social · last yr.

White smoke, we have a new pope and also 16 new anti-phages systems in sedentary integrons (SCIs) ! In collaboration with the Rocha lab, we show in our new paper that cassettes of these large platforms encode many known anti-phage defenses, and uncovered 16 new ones. www.science.org/doi/10.1126/...

La tribune du mouvement Stand Up for Science France parue ce matin dans Le Monde (texte complet et signataires en ALT). Mobilisons-nous le 7 mars pour défendre la recherche scientifique et l'université ! #StandUpforScience #StandUpforScienceFrance

New updates on our plague vaccine: we now report that the type 3 secretion system is important for innate and adaptative immunity mechanisms and useful for protection in our live Yersinia pseudotuberculosis producing the F1 pseudocapsule 👇 www.sciencedirect.com/science/arti...

Following criticisms raised concerning our article www.nature.com/articles/s41..., we just confirmed our original conclusions, demonstrating that the rs2549794 variant near the ERAP2 locus displays a strong positive selection signal associated with the Black Death ☠️ www.nature.com/articles/s41...

Reply to: Insufficient evidence for natural selection associated with the Black Death - Nature

Nature - Reply to: Insufficient evidence for natural selection associated with the Black Death

nature.com