Here, we find that many Genomic islands have origins of transfer (oriT) mobilisable by conjugation, incl. known Pathogenicity & defense islands. iOriT use only an oriT for transfer by hitching on conjugative elements: they make abundant, diverse, ancient families of mobile genetic elements. See🧵

Manuel Ares-Arroyo@aresarroyom.bsky.social · 8mo ago

Bacteria chromosomes contain Genomic Islands that provide virulence, antibiotic resistance, MGE-defence,... They transfer between cells, but the mechanism of most remains elusive. Here we explore the conjugative capacity of these mysterious Genomic Islands. www.biorxiv.org/content/10.6...

🚨L'ENS de Lyon recrute un.e maître de conférence qui rejoindra le CIRI pour développer ses recherches sur l'immunité bactérienne, les transferts horizontaux et les MGE. 📖 Une très belle opportunité d'enseigner à des étudiants brillants tout en menant des recherches excitantes !

Thomas Henry@cinflammasome.bsky.social · 8mo ago

📢 Recruitment of an Associate Professor (Maître de conférences) in Bacteriology at CIRI and ENS de Lyon. Research at @ciri-lyon.bsky.social @francoisrousset.bsky.social @labxc.bsky.social Anti-phage Immunity, Horizontal gene/ MGE transfer 📚 Teaching at ENS de Lyon within the Department of Biology.

Bacteria chromosomes contain Genomic Islands that provide virulence, antibiotic resistance, MGE-defence,... They transfer between cells, but the mechanism of most remains elusive. Here we explore the conjugative capacity of these mysterious Genomic Islands. www.biorxiv.org/content/10.6...

Bacterial genomes encode a rich repertoire of antiphage systems, but we still know surprisingly little about when these systems are actually expressed. In this preprint, Lucas Paoli et al, ask what shapes antiphage systems expression in native contexts. www.biorxiv.org/content/10.6...

Environment and physiology shape antiphage system expression

Bacteria and archaea encode on average ten antiphage systems. Quorum sensing, cellular, or transcription factors can regulate specific systems (CRISPR-Cas, CBASS). Yet, a systematic assessment of anti...

biorxiv.org

@morgan-lamberioux.bsky.social @amazeld.bsky.social et al. reveal that nearly half of all bacterial genomes carry more than one Peptide deformylases gene; these are essential for bacterial viability and are targets for antibiotic development. 🔗 doi.org/10.1093/molbev/msaf311 #evobio #molbio

Unraveling the Prevalence and Multifaceted Roles of Accessory Peptide Deformylases in Bacterial Adaptation and Resistance

Abstract. Peptide deformylases (PDFs) are enzymes that are essential for bacterial viability and attractive targets for antibiotic development. Yet, despit

doi.org

Inspiring presentation by @miriammerad.bsky.social yesternight at the @pasteur.fr PhD Graduation ceremony. A call for action! Thank you Miriam!

Our new paper is out in @narjournal.bsky.social We show that natural transformation enables bacteria to shuffle integron cassettes, boosting their phenotypic diversity. academic.oup.com/nar/article/... 1/5

Bacterial natural transformation drives cassette shuffling and simplifies recombination in chromosomal integrons

Abstract. Integrons act as biobanks of gene cassettes conferring functions crucial for bacterial defense, including protection against phages and antibioti

academic.oup.com

Happy to be part of this! Besides conjugation, another way to acquire integron cassettes 🧬📼

Kevin Debatisse@kdebatisse.bsky.social · 10mo ago

Our new paper is out in @narjournal.bsky.social We show that natural transformation enables bacteria to shuffle integron cassettes, boosting their phenotypic diversity. academic.oup.com/nar/article/... 1/5

🎓🏆 Two Institut Pasteur PhD students honored at the 2025 Chancellerie des Universités de Paris Prizes! 👏 @nellsaunders.bsky.social – coronavirus research 👏 Antonin Verdier – optogenetic implant for hearing restoration Excellence in doctoral research 🌟 www.sorbonne.fr/la-chancelle...

Prix Universitaires - Chancellerie des Universités de Paris - Sorbonne

Les Prix Universitaires de la Chancellerie des Universités de Paris - Sorbonne : prix solennels, prix de thèse en droit et en sciences économiques.

sorbonne.fr

Use antisense oligomers to silence phage genes and discover new biology. @jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @helmholtzhzi.bsky.social @uni-wuerzburg.de print: www.nature.com/articles/s41... highlight: www.nature.com/articles/s41... briefing: www.nature.com/articles/d41...

🦠💊 L’Institut @pasteur.fr vient de publier un communiqué de presse sur nos récents travaux, qui décrivent une nouvelle piste pour augmenter l’efficacité des antibiotiques. #Pasteurdon #Recherche #Science #AMR Merci à toutes celles et ceux qui ont contribué. 📘 English version coming soon!

Une piste prometteuse pour augmenter l’efficacité des antibiotiques

Les aminosides sont des antibiotiques efficaces contre de très nombreuses bactéries telles que Escherichia coli, Pseudomonas aeruginosa ou Staphylococcus aureus. Mais jusqu’à présent, personne ne sava...

pasteur.fr

Many antiphage systems use NAD+, in many ways. @hugovaysset.bsky.social reviewed them all! Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity! www.cell.com/molecular-ce...

The multifaceted roles of NAD+ in bacterial immunity

In this review, Vaysset and Bernheim examine how nicotinamide adenine dinucleotide (NAD+) is a key player in diverse and widespread bacterial antiphage defense systems and phage counterdefense. The au...

cell.com

On Thursday, October 9th, I successfully defended my PhD in Genetics and Genomics, on the diversity, function and evolution of integron cassettes, at @pasteur.fr. Thanks to my PhD supervisor, @epcrocha.bsky.social and to my jury, headed by Ingrid Lafontaine!

Happy to announce that our comparative metagenomic analysis of the gut microbiota of five honeybee species - spearheaded by @aiswarya.bsky.social - is finally published in a peer-reviewed journal! rdcu.be/eKMCs @fbm-unil.bsky.social @dmf-unil.bsky.social 🧵👇

Evolution of gut microbiota across honeybee species revealed by comparative metagenomics

Nature Communications - Here, the authors perform metagenomic analysis of honeybee gut microbes, uncovering many previously unidentified species and host specific differences in composition and...

rdcu.be

New preprint! Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠 Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare! An epic effort by Rosanna Wright www.biorxiv.org/content/10.1...

Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages

Only a fraction of bacterial genomes encode CRISPR-Cas systems but the selective causes of this variation are unexplained. How naturally virulent bacteriophages (phages) select for CRISPR immunity has...

biorxiv.org

Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols. Thread 1/n

[Podcast] Les chantiers de la recherche | "Génétique : l'ADN des bactéries comme source de savoirs" avec @eloilittner.bsky.social

Génétique : l’ADN des bactéries comme source de savoirs

Un pan de la recherche en génomique se propose d'étudier les bactéries, ces micro-organismes développent des mécanismes de défense particulièrement intéressants.

radiofrance.fr

Et bien c'est fait ! Première à l'antenne d'une radio nationale, dans la matinale de France Culture ce matin. Merci à Guillaume Erner de m'avoir accueilli, et à Juliette Devaux pour la préparation de l'émission. www.radiofrance.fr/francecultur...

Génétique : l’ADN des bactéries comme source de savoirs

Un pan de la recherche en génomique se propose d'étudier les bactéries, ces micro-organismes développent des mécanismes de défense particulièrement intéressants.

radiofrance.fr

Willing to join us @pasteur.fr for a PhD for a project on how interactions between mobile genetic elements shape bacterial adaptation? Subject to be tailored to candidates with keen interest in evolution, genomics, computational biology, microbiology. Check www.pasteur.fr/en/education...

Pasteur-Paris University International doctoral program​ (PPU)

OverviewIn 2009, the Institut Pasteur, the world leading biomedical research institute founded by Louis Pasteur in 1887, inaugurated the Pasteur Paris-University (PPU) international doctoral program i...

pasteur.fr

Institut Pasteur | 130 years of biomedical research@pasteur.fr · last yr.

🎓 Applications for Institut Pasteur's PhD programs open Sept 1-Oct 20, 2025 for October 2026 entry. Apply to up to 4 projects across 6 programs: PPU, PPU-IMAGINE @institutimagine.bsky.social, PPU-@ox.ac.uk, PPU-EID @upcite.bsky.social & more 🧬 Register now ✍️ www.pasteur.fr/en/education...

J'aurai la chance de présenter mes travaux de thèse sur France Culture, dans l'émission "Les Chantiers de la Recherche" ce lundi 15 à 6h45, avec Guillaume Erner. Pour les lève-tard, l'émission sera disponible en podcast. Stay tuned ! www.radiofrance.fr/francecultur...

Les Chantiers de la recherche : écouter le podcast et replay | France Culture

Chaque matin, entrez dans les coulisses de la recherche, avec celles et ceux qui la font vivre. Dans un laboratoire, une bibliothèque ou sur un terrain de fouilles, des chercheuses et des chercheurs n...

radiofrance.fr

Check out @julielebris.bsky.social’s thread on our latest manuscript describing phenotypic heterogeneity in capsule production in Klebsiella & Acinetobacter @klebclub.bsky.social This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social #microsky #phagesky

Julie Le Bris@julielebris.bsky.social · last yr.

Delighted to share our recently published work! Ever wondered how Klebsiella (and others) deals with capsule production’s costs ? The paper: journals.asm.org/doi/10.1128/... Thread👇

A new theme issue of #PhilTransB examines the evolutionary history of bacterial immune systems, their modes of action, and the patterns how different bacterial immune systems are distributed across different ecosystems. Read: buff.ly/Z4qdxY1

At last ! A tool specifically for phage-plasmid hunters. Check tyPPing by @karinailchenko.bsky.social and @eugenpfeifer.bsky.social

Karina Ilchenko@karinailchenko.bsky.social · last yr.

🚨 New preprint! 🧬 𝐏𝐡𝐚𝐠𝐞-𝐩𝐥𝐚𝐬𝐦𝐢𝐝𝐬 (𝐏-𝐏𝐬) are fascinating elements: both 𝐭𝐞𝐦𝐩𝐞𝐫𝐚𝐭𝐞 𝐩𝐡𝐚𝐠𝐞𝐬 and 𝐩𝐥𝐚𝐬𝐦𝐢𝐝𝐬 ➡️ tricky to detect. We present 𝐭𝐲𝐏𝐏𝐢𝐧𝐠 — the first 𝐢𝐝𝐞𝐧𝐭𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐜𝐥𝐚𝐬𝐬𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐭𝐨𝐨𝐥 🛠️designed specifically for P-Ps: ✅ Accurate ✅ Sensitive ✅ Easy to use 📖 www.biorxiv.org/content/10.1...

We are very proud of our researchers Beatrice Baragli, Jerome Beetz, Jacqueline Degen, Mona Garvert, Jake Greenfield, and Jens Hör: They have been awarded prestigious ERC Starting Grants worth €1.5 million. Congratulations! @erc.europa.eu #ERCStG ➡️ www.uni-wuerzburg.de/en/news-and-...

Congratulations to our #HIRI group leader and JMU junior professor @jenshoer.bsky.social on receiving a 1.5 million euro #ERCStG from @erc.europa.eu! In his RIBO-PHAGE project, he will study phages—viruses that infect bacteria—with RNA genomes. 🥳👏 @helmholtzhzi.bsky.social @uni-wuerzburg.de

I'm really happy to have been granted an @erc.europa.eu Starting Grant! We'll study the molecular principles of RNA phages—from infection to replication to bacterial immunity. Interested in joining? Feel free to reach out! Formal job ads to follow. More info here: tinyurl.com/RIBO-PHAGE #ERCStG

Preprint: We discovered phage proteins that sequester diverse immune signaling molecules, including cUMP, cCMP, and N7-cADPR The first viral sponges to inhibit Pycsar and type IV Thoeris Congrats to talented leading author Romi Hadary! Read her thread to learn more about our findings

Romi Hadary@romihadary.bsky.social · last yr.

📢 Preprint out! Together with @reneechang.bsky.social @kranzuschlab.bsky.social and the amazing @soreklab.bsky.social, we explored viral sponges to map their diversity and function. Discovered huge diversity, including sponges that inhibit Pycsar & Type IV Thoeris! www.biorxiv.org/content/10.1...

Mind-blowing tour-de-force for synthetic biology and immunity 🤯 Congrats @garbjeremy.bsky.social and @soreklab.bsky.social 🤩

Sorek Lab@soreklab.bsky.social · last yr.

Preprint: De-novo design of proteins that inhibit bacterial defenses Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications Congrats Jeremy Garb! tinyurl.com/Syttt 🧵

Im Kampf gegen multiresistente Keime können #Bakteriophagen eine weitere Waffe sein. Für sein Projekt "RIBO-PHAGE" erhält @jenshoer.bsky.social, Nachwuchsgruppenleiter @helmholtz-hiri.bsky.social, nun einen #ERCStG des @erc.europa.eu!🎉 Herzlichen Glückwunsch! www.helmholtz-hzi.de/media-center...

Super excited to receive the ERC starting grant to explore what phage-bacteria interactions can teach us on host-pathogen conflicts 🤩 I'm immensely grateful to my wonderful team and to present and past mentors 🙏

European Research Council (ERC)@erc.europa.eu · last yr.

📣 The ERC Starting Grant call results are out! Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025! ➡️ buff.ly/IsafuFh #FrontierResearch 🇪🇺#EUfunded #HorizonEurope