Pío Sierra
@piosierra.bsky.social
Research Assistant at University of Cambridge. Mobile DNA, pangenomes, things that evolve. Investigador en la Universidad de Cambridge. ADN móvil, pangenomas, cosas que evolucionan.
🎨 job alert 🐠 Come join us! We have two positions open! These are part of our @erc.europa.eu funded project on the mechanisms underpinning convergence of colour patterns in cichlid fishes! Closing date: 16th August. Postdoc: www.cam.ac.uk/jobs/researc... Technician: www.cam.ac.uk/jobs/researc...
Callipterus Cichlid Collecting Shell
ALT: Callipterus Cichlid Collecting Shell
static.klipy.com
Excellent news for the Transposable Elements research community. Congratulations to everyone who made this possible. #Dfam #Repbase link.springer.com/article/10.1...
Unifying Repbase and Dfam: a new open foundation for transposable element research - Mobile DNA
Repbase and Dfam, the two foundational resources for transposable element annotation, are being unified into a single, fully open access framework, with Repbase released under CC-0 and its core curati...
link.springer.com
A new RepeatModeler release is available. It adds compatibility with RepeatMasker 4.2.4 and the Dfam 4.0 FamDB format. TETools containers have also been updated with the latest RepeatMasker, RepeatModeler, and FamDB releases. See repeatmasker.org for details
RepeatMasker Home Page
repeatmasker.org
Department of Genetics is hiring a Research Associate (Fixed Term) Details on how to apply: www.cam.ac.uk/jobs/researc...
The Department of Genetics at the University of Cambridge is seeking a talented Postdoctoral Research Associate to work in the group of Dr Felipe Karam Teixeira (www.gen.cam.ac.uk/research-gro...) ➡️For Further details see the link www.cam.ac.uk/jobs/postdoc...
Postdoctoral Research Associate (Fixed Term)
Applications are invited for a Postdoctoral Research Associate position to work in the group of Dr Felipe Karam Teixeira (https://www.gen.cam.ac.uk/research-groups/research-groups/karam-teixeira) in
cam.ac.uk
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity www.science.org/doi/10.1126/... @levine-lab.bsky.social very cool work
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity
Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...
science.org
Kicked off a series on #Drosophila TE discovery and naming. The first post covers elements that predate the term "mobile element", and more. artemilin.dev/posts/te_nam...
Drosophila TE name origins, Part 1 – Postdoc Postpunk
artemilin.dev
🌎👩🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵 Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open. doi.org/10.1101/2024...
This is really cool!
Flora Gaudillière-Jami@fgaudilliere.bsky.social · last yr.The preprint of my first article is available on bioRxiv! We use a transposon ecology framework to analyze the distribution of insertion sequences within prokaryotic genomes. We characterize their ecological niche and show evidence of niche construction 🧪🧬💻 www.biorxiv.org/content/10.1...
Ever wonder how nature got so diverse? The secret might lie in these colorful cichlid fish 🐠 Cambridge scientists discovered that ‘flipped’ segments of DNA act like evolutionary turbo boosts — helping species adapt fast and evolve into new ones. 👇 www.science.org/doi/10.1126/science.adr9961
What do we know about the earliest history of cichlid fishes? Here’s an extended and updated English version of my article on the biogeography and early evolution of cichlids, which I originally published in German in 2020. 🐟 🧪 #cichlid #biogeography #paleontology cichlidae.com/article.php?...
Biogeography, evolution, and ecology of the ancestral cichlids
This article examines the early evolution and biogeography of cichlids, discussing fossil evidence and the hypotheses regarding their origins. It reviews the debate between Gondwanan vicariance and ma...
cichlidae.com
Latest findings on cryptic infection of giant viruses published in @ScienceMagazine. We discovered a large virus hiding within a green algal genome producing virions. www.science.org/doi/10.1126/...
Cryptic infection of a giant virus in a unicellular green alga
Latency is a common strategy in a wide range of viral lineages, but its prevalence in giant viruses remains unknown. Here we describe a 617 kbp integrated giant viral element in the model green alga C...
science.org
1/10 Today in @science.org in collaboration with the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...
📢 HPRC Release 2 is here! Now with phased genomes from 200+ individuals, a 5x increase from Release 1. Explore sequencing data, assemblies, annotations & alignments in our interactive data explorer ⬇️: humanpangenome.org/hprc-data-re...
Massively parallel jumping assay (MPJA) enables to test the jumping potential of thousands of transposons. Analysis of >160,000 Alu haplotypes identified transposition-asssociated domains. Amazing work by Navneet Matharu, Jingjing Zhao, Martin Kircher and many others. www.nature.com/articles/s41...
Massively parallel jumping assay decodes Alu retrotransposition activity - Nature Communications
Here, the authors develop a high-throughput assay to measure the jumping potential of thousands of transposons in parallel.
nature.com
"Essential components of the genome", indeed.
Cedric Feschotte@cedricfeschotte.bsky.social · last yr.💥🥳 At long last, our latest paper is out! Gag proteins of endogenous retroviruses are required for zebrafish development www.pnas.org/doi/10.1073/... Led heroically by Sylvia Chang & @jonowells.bsky.social A study which has changed the way I think of #transposons! No less! 🧵 1/n
😍 communities.springernature.com/posts/celebr...
Celebrating DNA Day with transposable elements
Each year on DNA Day, we celebrate the DNA double helix structure and the Human Genome Project's completion. Here we dive into a fascinating genomic component: transposable elements. Once seen as mere...
communities.springernature.com
This is a such a great work! So many things to find out now that we start having complete™ genomes.
Adam Phillippy@aphillippy.bsky.social · last yr.A project five years in the making, we've now published complete "T2T" genomes for six additional ape species! It turns out that finishing (and analyzing) six genomes is slightly more work than one... doi.org/10.1038/s415...
I’m very proud and happy to share the first paper of my PhD with @millanek.bsky.social that is now published in the latest issue of the journal Evolution @journal-evo.bsky.social. academic.oup.com/evolut/artic...
Rapid evolution of recombination landscapes during the divergence of cichlid ecotypes in Lake Masoko
Abstract. Variation of recombination rate along the genome is of crucial importance to rapid adaptation and organismal diversification. Many unknowns remai
academic.oup.com
I was so much looking for this after I saw her presenting it last year. Great story!
Maya Voichek@mayavoichek.bsky.social · last yr.1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇
An excellent postdoc opportunity with Adrian Baez-Ortega at the University of Cambridge on the genomics of transmissible cancer. Adrian is a brilliant scientist and mentor, this is a fantastic opportunity I strongly recommend.
www.nature.com/articles/s41... In collaboration with Andrew Lang and Alison Buchan, we just published a review on the complex and sometimes convoluted interactions and evolutionary relationships among bacterial mobile genetic elements. #phage #plasmid #evolution #bacteria #plasmidbiology #MGE
Interactions and evolutionary relationships among bacterial mobile genetic elements - Nature Reviews Microbiology
In this Review, Lang and colleagues present an overview of the current knowledge landscape regarding mobile genetic elements in bacteria, with a focus on their evolutionary relationships and interacti...
nature.com
We did it! We caught Starship #transposons moving between #fungal species in the lab, including between species separated by ~100my. We think Starships are a mediator of HGT in fungi, akin to conjugative elements in bacteria. Check out the preprint. www.biorxiv.org/content/10.1...
Why do some animals, like whales, live exceptionally long lives free from many age-related diseases? 🐋 Join Dr Alex Cagan to find out how nature’s solutions to longevity may hold the key to tackling our own health challenges. 🗓️ 03 April ⌚ 8-9pm 📍 Cambridge Union 🎫 Booking required
Did you know that two jumping sequences (LINE-1 and Alu) make up nearly 30% of our genomes? Ever wonder how they jump into new genomic sites? We have some exciting discoveries to share new in @science.org on the structural mechanisms of LINE-1 retrotransposition (aka jumping 🧬➡️🧬) 🧪 #ScienceResearch
