@biorxivpreprint.bsky.social The transition to postpartum lactation establishes a state of maternal antiviral resilience www.biorxiv.org/content/10.6... @kelliejurado.bsky.social @pennmedicine.bsky.social

A multiomic atlas of pregnancies with chronic placental inflammation links effector activation to preterm birth and regulatory resilience to term delivery www.science.org/doi/10.1126/... @ngllab.bsky.social @washumedicine.bsky.social

Proud and honored to share our new paper in @sciimmunology.bsky.social! Fibrinoid-associated neutrophils promote invasive placentation and shape neutrophil reprogramming at the maternal–fetal interface. @ailackner.bsky.social ial, @meduniwien.ac.at ien.ac.at doi.org/10.1126/scii...

Fibrinoid-associated neutrophils promote invasive placentation and neutrophil reprogramming at the maternal-fetal interface

Neutrophils adopt a tissue-adapted state at the early maternal-fetal interface that supports trophoblast invasion.

doi.org

A study in Nature Medicine shows that low levels of maternal serum ISM2 in early pregnancy may indicate increased risk of preeclampsia and fetal growth restriction. go.nature.com/4iaOReD #medsky 🧪

Adding albumin to popular antibody-based medicines helps to block their passage through the placenta go.nature.com/4ikDmkB

To shield the fetus, link a protein to these drugs

Adding albumin to popular antibody-based medicines helps to block their passage through the placenta.

go.nature.com

Feels like something @devoevomed.bsky.social should know about: www.science.org/doi/10.1126/...

Reassessing the role of progesterone receptor isoforms PGR-A and PGR-B in female fertility

Progesterone is a critical reproductive hormone that acts via progesterone receptor transcriptional regulators. The short PGR-A isoform lacks a 164–amino acid amino-terminal region present in PGR-B th...

science.org

A scientist is helping uncover the role of the immune system in endometriosis—while managing the disease herself. Learn more: https://scim.ag/4oDvjAa #ScienceMagArchives

ICYMI: Eosinophils shape barrier immunity during reproduction

Eosinophils shape barrier immunity during reproduction

Nature Reviews Immunology, Published online: 29 May 2026; doi:10.1038/s41577-026-01317-yEosinophils remodel the maternal intestine during pregnancy and lactation, promoting goblet cell differentiation and strengthening barrier immunity.

dlvr.it

I went back to capture what the astronauts said in full when the clock was stopped at T-10 minutes and they were asked if they were go for launch: This is Victor. We are going for our families. This is Christina. We are going for our teammates. This is Jeremy. We are going for all humanity.

Dr. Jessie Christiansen@aussiastronomer.bsky.social · 6mo ago

"OUTSTANDING."

Excited to share my new preprint from the McKinley lab, where we explored regenerative mechanisms across menstruation and pregnancy! We thought specialized glands would regenerate everything. We were wrong. But the real mechanism turned out to be way cooler :) 🧪🧵 www.biorxiv.org/content/10.6...

This was so fun! Thank you so much to @cindyleifer.bsky.social and @microbetv.bsky.social for the opportunity to discuss pregnancy immunology ✨

Microbetv@microbetv.bsky.social · 7mo ago

@cindyleifer.bsky.social talks with Gabrielle Rizzuto from Memorial Sloan Kettering Cancer Center about her work on the curious immunology of pregnancy and how a woman tolerates a genetically different baby but quickly rejects a mismatched organ donation.

I'm thrilled to share that the first paper from my PhD is out today in @cp-immunity.bsky.social! Here, we investigated how phagocytes, such as macrophages, handle microplastics (MPs) during their normal functions. www.sciencedirect.com/science/arti...

Polystyrene microplastic-induced pathophysiology is driven by disruption of efferocytosis

Microplastics (MPs), microparticles from plastic degradation, pose a substantial threat to human health. Macrophages, the body’s immune sentinels, are…

sciencedirect.com

Justin Perry - Perry Lab@justinperryphd.bsky.social · 8mo ago

Those who know me, know I’m not someone who changes his preferences & behaviors lightly. As Ron Swanson said, “I regret nothing. The end.” Well, let me tell you about our new study, out from The Perry Lab @mskcancercenter.bsky.social in @cp-immunity.bsky.social, which is the exception. /1

Out now: We present antibody-lectin chimeras (AbLecs) as a molecular platform to target sugars, or glycans, for cancer immunotherapy. www.nature.com/articles/s41... www.nature.com/articles/s41... @mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social

Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology

Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.

nature.com

Congratulations @jcstark.bsky.social and the team, antibody-lectin chimeras (AbLecs), a new modality for cancer immune therapy, now published @natbiotech.nature.com. These bispecifics can block glyco-immune checkpoint receptor ligands directly at the immune synapse/activate immune effector functions

Nature Biotechnology@natbiotech.nature.com · 10mo ago

Antibody-lectin chimeras for glyco-immune checkpoint blockade - @jcstark.bsky.social @carolynbertozzi.bskyverified.social go.nature.com/4aRDpk8

Using proximity labeling and a derivatized galectin-3, scientists in the lab of Professor Mia Huang mapped glycan–protein interactions that drive placental cell fusion, published in @pnas.org, offering new insight into placental development.

Scripps Research team identifies sugar molecules that trigger placental formation

ow.ly

“Rizz-ard of Oz: there’s no place like lab” Happy Halloween! Thanks IGO for the annual party 🎃

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀 Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities. Sign up. Stay informed. Join the movement: www.nycures.org/

🚨Today, in #NatureCancer, we show that #CAR-T cells and #CAR-NK cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS enhances CAR potency against liquid and solid cancers. rdcu.be/exjEy. @mskcancercenter.bsky.social @parkerici.bsky.social

CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit

Nature Cancer - Klebanoff and colleagues report that survival and persistence of CAR-T and CAR-NK cells are regulated by a FAS ligand–FAS autoregulatory circuit, showing that disabling FAS...

rdcu.be

We are so proud of Mergim for passing his quals! Definitely warrants lollipops advertising his favorite model antigen.

Researchers at the Crick have found that pregnancy in mice leads to the irreversible growth of their small intestine. www.crick.ac.uk/news/2025-03...

Pregnancy irreversibly remodels the mouse intestine

Researchers at the Francis Crick Institute have found that the small intestine grows in response to pregnancy in mice. This partially irreversible change may help mice support a pregnancy and prepare ...

crick.ac.uk

Exciting news! To welcome our new lab members from the past year and reaffirm our commitment to women’s health and pregnancy immunology, we’ve launched our lab website. Check it out- and if this fascinating niche in immunology speaks to you, let’s connect! www.therizzutolab.com

The Rizzuto lab

therizzutolab.com

What determines the length of gestation? A short thread… (1/5)