🔬 Large-scale cancer genomics can identify biomarkers of treatment non-response, helping spare patients ineffective therapies. New #VHIO–Hartwig Medical Foundation study in @myesmo.bsky.social, first-authored by Joseph Usset and led by @franmj88.bsky.social. ➡️ https://linke.to/ESMORWFMartinez

👏 ¡Enhorabuena, @franmj88.bsky.social ‼️ El jefe del Grupo de Inmunogenómica Computacional del #VHIO recibe el I Premio Joven Investigador Biomédico #FundaciónCobos por sus contribuciones en genómica computacional del cáncer. ➡️ https://linke.to/PremioCobosMartinezVHIO_Cast @cerca.cat

👏 Enhorabona, @franmj88.bsky.social‼️ El cap del Grup d'Immunogenòmica Computacional del #VHIO rep el I Premi Jove Investigador Biomèdic #FundaciónCobos per les seves contribucions en genòmica computacional del càncer. ➡️ https://linke.to/PremioCobosMartinezVHIO_Cat @cerca.cat

📣 Are you an #MD passionate about research?  Fundació Catalunya La Pedrera #VHIO MD-PhD Fellowship is now open! 🚀 An excellent opportunity for MDs who wish to become experts in translational medicine 👉 https://linke.to/FellowshipPedreraVHIO2026 📅 Deadline: May 14th @cerca.cat

Excited to share our ‘Evolutionary characterization of lung cancer metastasis’ in #TRACERx & #PEACE, published today in @nature.com in collaboration with @charlesswanton.bsky.social @nickymcgranahan.bsky.social @zaccasimo.bsky.social at @ucl.ac.uk & @crick.ac.uk. www.nature.com/articles/s41...

Evolutionary characterization of lung cancer metastasis - Nature

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...

nature.com

Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr

Tumor promotion through the lens of evolution This review grew out of many long conversations, shared ideas, and lively discussions It has been a real pleasure to think together with Allan, Paul, Eve, and Abel about how tumours develop and how carcinogens shape cancer risk rdcu.be/fdC2J

Tumour promotion through the lens of evolution

Nature - This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable...

rdcu.be

Monthly median Received to Accepted time (days) at Nature Genetics

Why should tumor whole genome sequencing (WGS) be done for cancer? In real practice of medicine study of 888 patients with solid cancers, WGS directly led to clinical consequences in over 40% www.nature.com/articles/s41...

Real-world clinical utility of tumor whole-genome sequencing in solid cancers - Nature Medicine

In a real-world cohort of 888 patients with solid cancers receiving whole-genome sequencing profiling, actionable biomarkers were identified in 73% of patients, and targeted therapies were associated ...

nature.com

Here's a short guide to good practices for #8M, that we've prepared from the Equality Commission of @vhio.bsky.social.

‼️Last days to apply for our postdoc position in the group! Please share!! jobs.vhio.net/en/jobs/7256...

2026-018-01 Postdoctoral fellow in cancer immunogenomics - VHIO

Under the leadership of Josep Tabernero, VHIO is an internationally recognized cancer center. Its multidisciplinary, collaborative model drives scientific progress and innovative cancer treatments.

jobs.vhio.net

Today in @science.org: We are pleased to present our last work entitled: "Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis" by Zumalave et al. www.science.org/doi/10.1126/...

Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis

LINE-1 (L1) retrotransposition generates somatic genomic variation in human cancer, but short-read sequencing has limited our understanding of its structural consequences and dynamics. Using long-read...

science.org

Today is #WorldCancerDay ~1 in 5 people will develop #cancer in their lifetime Each diagnosis affects not just one person, but families, communities, and futures Grateful today for patients, clinicians, researchers & advocates - and to appreciate that progress depends on acting together #WCD2026

Convocatoria abierta para las Becas FERO 2026! 🔬destinadas a impulsar la investigación oncológica traslacional en España. 6 becas en 4 categorías diferentes 👉 toda la info fero.org/para-investi... #BecasFERO #ConvocatoriaAbierta #OpenCall #FundaciónFERO #FERO

Huge congratulations to Fran on being awarded the ERC Consolidator Grant! 🎉 Such a well-deserved recognition of an outstanding trajectory and a truly creative, exciting proposal on T-cell clonal hematopoiesis. Can’t wait to see the discoveries that come out of this project. So proud of you! 👏✨

Vall d’Hebron Institute of Oncology@vhio.bsky.social · 8mo ago

👏 Congratulations to Francisco Martínez Jiménez‼️ The head of the Computational Immunogenomics Group at #VHIO has been awarded an @erc.europa.eu Consolidator Grant to uncover new immunotherapy strategies built on expanded T-cell clones. ➡️ https://linke.to/ERCFranMVHIO #ERCCoG @cerca.cat

👏 ¡Enhorabuena Francisco Martínez Jiménez‼️ El jefe del Grupo de Inmunogenómica Computacional del #VHIO ha recibido una Consolidator Grant del @erc.europa.eu para investigar nuevas estrategias de inmunoterapia basadas en clones expandidos de linfocitos T. ➡️ https://linke.to/ERCFranMVHIO_Cast #ERCCoG

new out in Nature www.nature.com/articles/s41...

New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...

Epigenetically driven and early immune evasion in colorectal cancer evolution - Nature Genetics

This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

nature.com

Fantastic #Blutorial by our friends and colleagues at the @batllelab.bsky.social . We are so happy to collaborate with them. @meritxellnov.bsky.social and Mireia Novell in the lab have participated in this very important piece on metastatic colorectal cancer. 👏🏼👇🏼👇🏼👇🏼 aacrjournals.org/cancerdiscov...

The Batlle Lab@batllelab.bsky.social · 10mo ago

🧵1/17 📣Thrilled to share our latest study just out in Cancer Discovery! ➡️ aacrjournals.org/cancerdiscov...

Postdoc | VHIO, Barcelona Immunotherapies succeed in only ~20% of cases. Help us break resistance by engineering the right environment. Join the Aging & Cancer Lab 🌍 👉 Apply: vhiovidaprogramme.eu/recruitment/ | mauslab.org

Finding somatic mutations in healthy tissue that can lead to cancer, at scale. Yet another path to primary prevention www.nature.com/articles/s41... www.nature.com/articles/d41...

1/ 🚀 Excited to share our preprint tackling a key gap in precision oncology: the lack of robust non-response biomarkers to guide clinical decisions. These markers can spare patients from ineffective treatments and ease pressure on healthcare systems. www.biorxiv.org/content/10.1...

Working alongside with Fran, a no brainer 👇🏼

Fran Martínez-Jiménez@franmj88.bsky.social · 10mo ago

🚨 International Postdoctoral Positions Open at VHIO! 🚨 The VHIO VIDA Postdoctoral Program is now open! We’re a fully funded position for international postdocs to work on cutting-edge exciting projects, develop professionally, and pave the way toward independence. 👉 vhiovidaprogramme.eu

🚨 International Postdoctoral Positions Open at VHIO! 🚨 The VHIO VIDA Postdoctoral Program is now open! We’re a fully funded position for international postdocs to work on cutting-edge exciting projects, develop professionally, and pave the way toward independence. 👉 vhiovidaprogramme.eu

How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite www.cell.com/cell/abstrac...

The obsession with economic output as a measure of human development puts sustainability on the back burner Time to end the GDP mania Our editorial inspired by a @nature.com paper that looks at how the world should really measure prosperity 🧪 #SGDs #doughnuteconomics www.nature.com/articles/d41...

End GDP mania: how the world should really measure prosperity

The obsession with economic output as a measure of human development puts sustainability on the back burner. Researchers can now help to devise better indicators.

nature.com

The richest 20% of nations, with 15% of the global population, contribute more than 40% of annual ecological overshoot; the poorest 40% of countries, with 42% of the global population, experience more than 60% of social shortfall 🧪 A new analysis by Fanning & Raworth www.nature.com/articles/s41...

Doughnut of social and planetary boundaries monitors a world out of balance - Nature

A revised ‘Doughnut’ providing a visual assessment of trends in social deprivation and planetary degradation over the past two decades shows more than doubling of global GDP accompanied by accelerating ecological overshoot but only a modest reduction in human deprivation.

nature.com

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n www.biorxiv.org/cgi/content/...

Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature

Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...

biorxiv.org

www.science.org/doi/10.1126/...

Aberrant basal cell clonal dynamics shape early lung carcinogenesis

Preinvasive squamous lung lesions are precursors of lung squamous cell carcinoma (LUSC). The cellular events underlying lesion formation are unknown. Using a carcinogen-induced model of LUSC with no a...

science.org