Banger of a funding acknowledgment 😂 academic.oup.com/ajeadvances/...

The next #CryoEM Current Practices Webinar speaker will be Jenn Cash from UCSD speaking on "Cryo-EM single-particle analysis of small and dynamic proteins" 7/30/2026 at 12 PM ET / 9AM PT Registration is at no-cost, but sign-up is required: us02web.zoom.us/webinar/regi...

Big thanks to Isabelle Baconguis (Vollum Institute) and her group for including us in their epic foray into the structural plasticity of ASICs, now out in Nature Structural and Molecular Biology: www.nature.com/articles/s41... 1/4

Conformational plasticity of human acid-sensing ion channel 1a - Nature Structural & Molecular Biology

Using cryo-electron microscopy, Cahill, Hartfield et al. identified six structural states of human acid-sensing ion channel 1a, revealing how acidic conditions and peptide toxins regulate channel acti...

nature.com

Geopickr works perfectly with MorphometricsX - and is especially powerful with morphometrics preprocessing like extracting only high curvature regions or mitochondria-ER contact sites!

ChimeraX@chimerax.ucsf.edu · 4w ago

A new ChimeraX tool Geopickr from Ben Barad's lab oversamples dense protein arrays on spheres, tubes, filaments, and arbitrary surfaces for geometry-assisted subtomogram averaging. Available from ChimeraX menu Tools / More Tools....

My personal summer of code continues with another ChimeraX plugin - this time, MorphometricsX! Load quantified meshes from morphometrics (or pycurv) in ChimeraX with color-by-quantification and display alongside tomos and particles. Coming to the toolshed soon! #teamtomo github.com/baradlab/mor...

Thanks to the @structurabio.bsky.social team for highlighting our recent work 😍

Structura Biotechnology@structurabio.bsky.social · last mo.

🔬Using #SingleParticle #cryo-EM on plaque-mimicking nanodiscs, researchers determined multiple connexin assembly states and uncovered lipid-protein interactions that may help understand gap junction organization and function. Read more in the latest #CryoSPARC Blog 👉 cryosparc.com/blog/gap-jun...

Just in time for the weekend, the 2nd beta for our Surface Morphometrics 2.0 release: github.com/GrotjahnLab/.... Beyond the major API change from the first beta (which used for the michigan class!), this one includes a major overhaul of the dual gaussian fitting for thickness and refinement.

Release 2.0.0b2 · GrotjahnLab/surface_morphometrics

A quality and robustness release on top of 2.0.0b1, focused on the density-profile bilayer fitting (mesh refinement and thickness measurement), a forgiving centralized config system, and packaging ...

github.com

What if learning structural biology felt more like playing a game? Meowtabolism aims to make the structural sciences more interactive, accessible & fun. If you have educational applications let Muyuan (or me) know. store.steampowered.com/app/4045010/... #CryoEM #ScienceOutreach #STEMEducation

Edward T Eng@edwardteng.bsky.social · 10mo ago

Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam. Try the demo here: store.steampowered.com/app/4045010/... Give Muyuan feedback: steamcommunity.com/app/4045010 #ScienceGaming #StructuralBiology #CryoEM #STEMOutreach

I had such a fun time teaching at the U Michigan Cryo-ET Course this week! I taught quantitative ultrastructure analysis and we made cool figures like these! My course materials are at baradlab.com/michigan_tutorial for anyone to try. Workflow include mesh refinement and thickness measurement!

“the best way to work with cryoET data is to engage with it directly, […] build familiarity with what is actually there. As tempting as it sometimes is to lean in to automation entirely, we cannot do visual proteomics by relying blindly on automation.” mgflast.github.io/easymode/use...

Better vitrification = better cryo-ET. We've opened an RFA for two-year grants to advance vitrification techniques for biological samples—welcoming applications from researchers in heat transfer, cryogenics, and materials science. Apply here: bit.ly/4uip6eJ

I've just released a small open-source utility for RELION users: relion_tracker. RELION stores a lot of useful information in the *_optimiser.star files, but I often found myself repeatedly grepping STAR files to see how metrics were changing across iterations.

Very excited about our new work highlighting the role of lipids in mediating multi-channel assemblies of Cx-46/50!

Reichow Lab@reichowlab.bsky.social · 2mo ago

Dual-channel Cx46/50 gap junction assemblies in a shared lipid-nanodisc = lipid-mediated packing and a lipid site near the NT gating region that is absent from single channels. Plus a 1.8 Å open-state single-channel benchmark! #cryo-EM 🍩’s #NIH-funded-research www.biorxiv.org/content/10.6...

Dual-channel Cx46/50 gap junction assemblies in a shared lipid-nanodisc = lipid-mediated packing and a lipid site near the NT gating region that is absent from single channels. Plus a 1.8 Å open-state single-channel benchmark! #cryo-EM 🍩’s #NIH-funded-research www.biorxiv.org/content/10.6...

Long shot, but, with lots of labs turning from crystallography to cryo-EM I’m wondering if anyone knows of labs potentially looking to offload some of their old crystallography supplies to a PUI with potential screening hits and really eager students but nothing to harvest with, etc.?

Interested in microbiology, immunology, and host-pathogen interactions? Come work with us! Our department at OHSU is opening a search for a new tenure-track faculty position. See the job advertisement for details. Please share within your networks! www.nature.com/naturecareer...

Faculty Position in Molecular Microbiology and Immunology - Portland, Oregon job with Oregon Health & Science University (OHSU) - Molecular Microbiology and Immunology | 12858852

The Department of Molecular Microbiology and Immunology at OHSU invites applications for a tenure-track Assistant or Associate Professor position.

nature.com

This was fitting news to receive on May 1, international workers day. I will be returning to work on Monday after being kept on retaliatory administrative leave for 5 months and 3 weeks. I return along with the brave Katrina Declaration signers from FEMA, also reinstated this week. 🧵1/?

Sheryl Gay Stolberg@sherylnyt.bsky.social · 3mo ago

NEWS: The NIH whistleblower @jenna-m-norton.bsky.social, who was put on paid leave in November after criticizing the Trump administration’s cuts to medical research, has been reinstated — without explanation. www.nytimes.com/2026/05/01/u...

I love that portrait of you, Dr. Norton: weary but unyielding. You did not concede and your character speaks through your actions. We all know that you have acted at great cost. Thank you for your bravery and your dedication to our craft, and to the mission of the US National Institutes of Health.

The 2027 Biophysical Society #CryoEM Subgroup welcomes nominations for the June Almeida Award for Mid/Senior-Career Women in CryoEM. The nomination deadline is November 13, 2026, but feel free to submit nominations anytime. Eligibility & requirements found here: www.biophysics.org/Awards-Fundi...

My lab is recruiting for a highly independent and talented postdoctoral fellow to work on answering fundamental biological questions. Reach out if you have questions! careers.gene.com/us/en/job/20...

Postdoctoral Fellow, Structural Biology, Hsu Lab in South San Francisco, California, United States of America | Students & Graduates at Genentech

Apply for Postdoctoral Fellow, Structural Biology, Hsu Lab job with Genentech in South San Francisco, California, United States of America. Students & Graduates at Genentech

careers.gene.com

Please repost! This comes from the good people at ChimeraX, who produce powerful up-to-date software to study protein (etc) structures, which are FREE to the community. 🙏 To stay viable and serve us, they need an experienced structural biologist to assume the leadership role on a funded project.

Faculty Position – In-Residence

University of California, San Francisco is hiring. Apply now!

aprecruit.ucsf.edu

The next #CryoEM Current Practices Webinar speaker will be by Miao Zhang from University of Arizona speaking on "Structural basis for the pharmacological modulation of KCa2.2 channels" 4/30/2026 at 12 PM ET / 9AM PT Registration is at no-cost, but sign-up is required: us02web.zoom.us/webinar/regi...

Excited to see this work out as a preprint! Proud to be part of this incredible international, multidisciplinary collaboration spanning structural biology, chemical biology, neuroscience, and translational medicine. This journey started ~7 years ago, and it’s been amazing!

@mansoorlabohsu.bsky.social · 4mo ago

Excited to share our latest preprint on bioRxiv! www.biorxiv.org/content/10.6... An international, multidisciplinary collaboration spanning structural biology, chemical biology, neuroscience, and translational medicine. Grateful to everyone involved in making this work possible!

Great day at NYSBC, thanks for having me! 😊 If anyone wants to try out the tutorial, here it is: www.dropbox.com/scl/fi/054cm... There are linked videos for each step in the PDF, or I have also prepared the whole thing as a .PPT with embedded videos (2.7GB): www.dropbox.com/scl/fi/jnl9h...

Edward T Eng@edwardteng.bsky.social · 5mo ago

Day 5 @olibclarke.bsky.social did double duty talking about model building & validation and giving a Coot/chimeraX tutorial. Also Justin Flatt from the @rcsbpdb.bsky.social shared best practices for #cryoEM deposition & validation.

Our department at Genentech is hiring. We're looking for a freshly-minted PhD (0-3 years) protein biochemist / structural biologist to join as a Sr Scientist. A rare opportunity to join our group leader job family at a more junior level than we usually hire.

Senior Scientist, Protein Sciences in South San Francisco, California, United States of America | Research & Development at Genentech

Apply for Senior Scientist, Protein Sciences job with Genentech in South San Francisco, California, United States of America. Research & Development at Genentech

careers.gene.com

🧪Help needed! I am currently gathering ideas for a new and updated Blender course tailored for chemists. Besides importing molecules into Blender, what topics or features would interest you the most? Any input is highly appreciated 😊

The next #CryoEM Current Practices Webinar speaker is Vladimir Kolyadko from Children’s Hospital of Philadelphia speaking on "Cryo-EM of Liposome-Assembled Macromolecular Complexes to Reveal Protein-Membrane Interactions in Hemostasis" 2/26/2026 at 12PM ET / 9AM PT us02web.zoom.us/webinar/regi...

I had Claude make this as a mini-game for Relay's disconnect screen (like Chrome's dinosaur), but then pivoted to stand-alone. In this game, you have to find Euler angles matching the target projection, i.e. cosplay RELION. It can be pretty hard. Works on mobile too! warpem.github.io/euler-hunt/

Euler Hunt

Can you find the Euler angles of a cryo-EM projection?

warpem.github.io

Join us this summer for U-M's 2026 #CryoET Data Processing Workshop! This four-day workshop will introduce participants to standard image processing packages and all aspects of cryo-ET data processing. Apply by March 20: myumi.ch/lsi-cryo-workshop-2026 @jbquerido.bsky.social @shyamalm.bsky.social