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Alister Burt

@alisterburt.bsky.social

Computational Cryo-EM/ET at Genentech Love people, the outdoors and building stuff Complexity is the enemy All opinions my own

372 Posts593 Follower582 Folgt
Guenter Resch@nexperion.net · 3mo ago

The feedback from participants at the #SerialEM Community Meeting 2026 in April — and the future of this format — have been central topics in our recent discussions. (Photo by Daniel Bollschweiler)

David Mastronarde and Guenter Resch at the stage of the 2026 SerialEM Community Meeting.
Alister Burt@alisterburt.bsky.social · 3mo ago

@mgflast.bsky.social showing us how to do cellular structural biology on easymode thanks to his collection of pretrained nets 😎 Particularly cool: he demonstrates custom tomo picking workflows e.g. yTuRC at the minus end of MTs, restricting picks to specific cellular compartments Check it out!

Allegretti Lab@matteoall.bsky.social · 3mo ago

We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇

Alister Burt@alisterburt.bsky.social · 4mo ago

Great read! I loved: “Curiosity is a stance you choose every morning. When a colleague pitches an idea, our default is “interesting — tell me more,” not “won’t work because.” Ideas don’t survive on their own; they survive because a few people gave them oxygen at the moment they were most fragile.”

Florian Jug@florianjug.bsky.social · 4mo ago

I’ve recently visited Detroit and read the really great Rocket ISMs booklet 🚀. It motivated me to work on ISMs that capture the spirit of the Multimodal AI Across Scales research direction we’re setting up @humantechnopole.bsky.social . What do you think about them? isms.maias.bio Honesty welcome!🙏

Alister Burt@alisterburt.bsky.social · 4mo ago

tl;dr: MissAlignment learns to score misalignment then wiggles your alignments around to reduce that misalignment -> no more misalignment = high res STA 🌟 Watching @martenchaillet.bsky.social chip away at this was a real privilege! I’m excited to see this out and what you all will do with it 🙃

Dimitry Tegunov@dtegunov.bsky.social · 4mo ago

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

Gregor Weiss@weiss-lab.bsky.social · 4mo ago

New preprint 🚀 ❄️ We developed Autogrid-compatible HPF planchettes that enable direct freezing of clipped EM grids and streamline integration with cryo-FIB workflows ✔️ improved grid stability ✔️ reduced handling ✔️ robust vitrification (🦠 🧫 🧠) A step toward routine HPF for complex samples #teamtomo

Damian Dalle Nogare@damiandn.bsky.social · 5mo ago

🚨🚨🚨JOB ALERT🚨🚨🚨 The Image Analysis Unit at Human Technopole in Milan is recruiting for two positions to join our growing team: 1) Bioimage Analyst 2) Research Software Engineer (RSE) Read on to learn why one of these two people should be you!

Aaron Reichlin-Melnick@reichlinmelnick.bsky.social · 5mo ago

Remember this from two months ago? Well, with herculean effort, we helped get those two gay men off the deportation flight to Iran, but they still remain locked in detention. Read more about what's happening now in their cases, and with other Iranians facing deportation. time.com/article/2026...

The Iranians Stuck Between ICE Detention and Deportation to War-Torn Homeland

An Iranian gay couple seeking asylum in the U.S. now faces deportation back to Iran as immigration policies tighten and deportation flights resume despite fears of persecution and death.

time.com

Aaron Reichlin-Melnick@reichlinmelnick.bsky.social · 7mo ago

My org @immcouncil.org represents those two gay men. They had been arrested on charges of sodomy by Iranian moral police, and fled the country seeking asylum. They face the death penalty if returned, yet the Trump admin denied their asylum claims in a kangaroo court process. They are terrified.

Two Iranian men, who are gay, told their lawyer Bekah Wolf with the American Immigration Council that they were set to be deported on the Sunday flight. Homosexuality is illegal and punishable by death in Iran, which executed two gay men in 2022 and is considered one of the world's most repressive countries for lesbian, gay, bisexual and transgender people. "They're terrified," Wolf told MS NOW. One of her clients "calls every 45 minutes begging me to save his life." "We need a court of some sort to fully hear their claims before they're sent back to a country where being gay is punishable by death," said Wolf. She said her two clients have no criminal convictions and entered the U.S. in early 2025 on asylum claims. Both were in the middle of appeals though did not have stays of removal, Wolf said. Ultimately, Wolf said, "they did not have full hearings of their asylum claims in any meaningful way."
Elise Cutts@elisecutts.bsky.social · 5mo ago

Call me a luddite I guess but I do in fact kind of die inside any time anyone tells me "ask Claude" when I ask them for advice about how to do something. As if teaching one another was just about passing 1 packet of knowledge from one brain to the next 😵‍💫

Alister Burt@alisterburt.bsky.social · 5mo ago

“think about whether some of the proprietary license money you’re currently spending could be spent instead on open solutions that would be yours forever, endlessly adaptable, and benefit the entire world. And please get in touch by emailing info@image.coop” 👏 👏 👏 Can’t wait to see where this goes

Image Cooperative@image.coop · 5mo ago

Hello, world! We are starting a worker cooperative to build, maintain, teach, and support open source scientific imaging software. image.coop/blog/posts/2...

Jeremy Berg@jeremymberg.bsky.social · 6mo ago

One of my father's favorite places in the world was the Exploratorium, a science museum in San Francisco. When he passed away in 1990, my brother and I donated funds to pay for the construction of an exhibit in his memory (on Fourier series). This is me with my two sons at the exhibit in 1990. 1/2

A man with his 7 year-old son and a 1 year old baby in his lap seated next to a complicated-looking museum exhibit.