Glycoproteoforms are the unit of biological information in the glycoproteome, but measuring intact glycoproteins to capture combinatorial modification states remains a huge #glycotime challenge. @timveth.bsky.social tackled this issue head on in the latest preprint from @riley-research.bsky.social

bioRxivpreprint@biorxivpreprint.bsky.social · last mo.

Defining glycoproteoform landscapes through an integrated glycoproteomics approach enabled by high-resolving power proton transfer charge reduction tandem mass spectrometry https://www.biorxiv.org/content/10.64898/2026.08.27.747529v1

The Riley Research Group is excited to be at #ASMS2026. There will be a lot of cool science this week, and we hope to add to the conversation with presentations from our group!

The Riley Research Group is excited to be at #ASMS2026. There will be a lot of cool science this week, and we hope to add to the conversation with presentations from our group!

Check out the newest entry in the ACS Div. of Analytical Chem. Education Committee's "Meet an Analytical Chemist" initiative. This quarter we highlight Dr. Christina Jones, Partnerships and Outreach Strategist at NIST: acsanalytical.org/2026/02/26/m...

Meet an Analytical Chemist – February 2026

Christina Jones, Ph.D.National Institute of Standards and Technology, Office of Advanced Manufacturing, Partnerships and Outreach Strategist How did you get started in the field of Analytical Chemistr...

acsanalytical.org

A big congratulations to the 2026 I. M. Kolthoff Award Winners! acsanalytical.org/2026/03/12/2... This @acs.org award for undergraduate researchers supported 4 outstanding students (Damon Chan, Alex Szczepankiewicz, Katelyn Barnes, & Zane Alsebai) attending @pittcon.bsky.social and #ACSspring 2026

2026 I. M. Kolthoff Award Winners

The I.M. Kolthoff Award is given annually to deserving undergraduates who have done undergraduate research in the field of analytical chemistry, broadly defined, in celebration of the life and accompl...

acsanalytical.org

The complexity of glycoproteomics data creates a bottleneck in data interpretation and communication. We (@timveth.bsky.social, @riley-research.bsky.social) built GlycoDiveR as a step toward bridging gaps between search-engine output and biological interpretation through #glycotime visualizations.

bioRxivpreprint@biorxivpreprint.bsky.social · 7mo ago

GlycoDiveR: a modular R framework to analyze and visualize highly dimensional glycoproteomics data https://www.biorxiv.org/content/10.64898/2026.03.21.713336v1

MS/MS scan range can be an afterthought that doesn't receive attention in method design, but improper settings can affect experimental outcomes. This is especially true in glycoproteomics. A #glycotime thread about a new #JASMS paper on this idea from @riley-research.bsky.social 1/10

A month behind the times, but I wanted to share an update from @emmajays.bsky.social and other co-authors in @riley-research.bsky.social. Our manuscript "Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona" is now published in Analytical Chemistry: pubs.acs.org/doi/abs/10.1...

Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona

Biofluids, such as plasma and cerebrospinal fluid (CSF), present significant challenges for proteome and glycoproteome analysis due to their complex protein composition and wide dynamic range of prote...

pubs.acs.org

Do you know outstanding undergraduate researchers who could use up to $1,000 in travel funding to present their work at the Spring @acs.org or @pittcon.bsky.social Meetings? Please encourage them to apply for a Kolthoff award! Deadline is Jan. 12, 2026. acsanalytical.org/undergraduat...

Awards for Undergraduate Students

Visit the post for more.

acsanalytical.org

Congratulations to Mike MacCoss on receiving the Donald F. Hunt Distinguished Contribution in Proteomics Award from US HUPO! us-hupo.org/Distinguishe...

US HUPO - Distinguished Contribution Award

us-hupo.org

Congratulations to Bill Noble on receiving the 2026 Gil Omenn Computational Proteomics Award from US HUPO! us-hupo.org/Computationa...

US HUPO - Computational Proteomics Award

us-hupo.org

Have fun with the poster presentation today @timveth.bsky.social!

Nick Riley@nmriley.bsky.social · 11mo ago

@timveth.bsky.social is not only attending #SFG2025 - he helped organize Glycopalooza events for early career researchers and is presenting poster B10-110 Tuesday. Check it out in session 2 to hear his impressive work integrating bottom-up and top-down methods to define glycoproteoform heterogeneity

@timveth.bsky.social is not only attending #SFG2025 - he helped organize Glycopalooza events for early career researchers and is presenting poster B10-110 Tuesday. Check it out in session 2 to hear his impressive work integrating bottom-up and top-down methods to define glycoproteoform heterogeneity

The overlap of #HUPO2025 with #SFG2025 this week means I’m missing out on the #glycotime fun at SFG in San Diego. I am happy postdoc @timveth.bsky.social is able to represent @riley-research.bsky.social at SFG instead!

If you are at #HUPO2025 and want to see some recent work from @riley-research.bsky.social, come check out Kayla’s talk on Monday afternoon in the Glycoproteomics session in the Frontenac Ballroom! My poster on our recent work informatics tools is on Monday afternoon too. See you there! #glycotime

🧪#glycotime

Nick Riley@nmriley.bsky.social · 12mo ago

Our manuscript describing @riley-research.bsky.social's GlyCounter informatics tool is now in press at Molecular and Cellular Proteomics. Congrats to first-author Katie Kothlow, her first first-author paper! The manuscript is available here: www.mcponline.org/article/S153...

Our manuscript describing @riley-research.bsky.social's GlyCounter informatics tool is now in press at Molecular and Cellular Proteomics. Congrats to first-author Katie Kothlow, her first first-author paper! The manuscript is available here: www.mcponline.org/article/S153...

Extracting informative glycan-specific ions from glycopeptide MS/MS spectra with GlyCounter

Glycopeptide tandem mass spectra typically contain numerous glycan-specific fragments that can inform several features of glycan modifications, including glycan class, composition, and structure. Whil...

mcponline.org

Nick Riley@nmriley.bsky.social · 2y ago

Here is a screenshot of the poster about GlyCounter I am presenting at this week's Glycobiology Gordon Research Conference to give you an overview of analyses we include in the pre-print.

Awesome to see GlyCounter at work! www.biorxiv.org/content/10.1...

Extracting informative glycan-specific ions from glycopeptide MS/MS spectra with GlyCounter

Glycopeptide tandem mass spectra typically contain numerous glycan-specific fragments that can inform several features of glycan modifications, including glycan class, composition, and structure. Whil...

biorxiv.org

Emmajay Sutherland@emmajays.bsky.social · last yr.

Hi Jochen! Using Glycounter (from RRG), we can classify MS/MS scans as 'likely glyco' from the presence of >8 oxonium ions. Here, NP+MAX yields around 60% of MS/MS scans with oxonium ions whereas neat plasma (NP0) has 4%.

Awesome to see GlyCounter at work! www.biorxiv.org/content/10.1...

Extracting informative glycan-specific ions from glycopeptide MS/MS spectra with GlyCounter

Glycopeptide tandem mass spectra typically contain numerous glycan-specific fragments that can inform several features of glycan modifications, including glycan class, composition, and structure. Whil...

biorxiv.org

Emmajay Sutherland@emmajays.bsky.social · last yr.

Hi Jochen! Using Glycounter (from RRG), we can classify MS/MS scans as 'likely glyco' from the presence of >8 oxonium ions. Here, NP+MAX yields around 60% of MS/MS scans with oxonium ions whereas neat plasma (NP0) has 4%.

Can nanoparticles help us probe the glycoproteome? The new pre-print from @riley-research.bsky.social seeks to answer this question using the Proteograph technology from Seer Inc. Check out this lovely study on glycoproteins NP-enriched from biofluids here: chemrxiv.org/engage/chemr...

Have you wondered how nanoparticle protein coronas (e.g., Seer’s Proteograph XT) can help with glycoprotein enrichment in biofluids? We were curious, too, and this new @riley-research.bsky.social pre-print led by outstanding postdoc @emmajays.bsky.social details our #glycotime investigations.

Emmajay Sutherland@emmajays.bsky.social · last yr.

Can nanoparticles help us probe the glycoproteome? The new pre-print from @riley-research.bsky.social seeks to answer this question using the Proteograph technology from Seer Inc. Check out this lovely study on glycoproteins NP-enriched from biofluids here: chemrxiv.org/engage/chemr...

This was so much fun! It was great to present and meet other incredible undergraduates at #ASMS2025. A huge thank you to @riley-research.bsky.social group members for their unwavering encouragement and even bringing me food and water during the presentations!

Ben Garcia@garcialabms.bsky.social · last yr.

The undergraduate poster session at #ASMS2025 is the place to be tonight.

@riley-research.bsky.social had a great time catching up with local research at the Cascadia Proteomics Symposium last week. The lineup featured talks from Katie Kothlow and Haley Schramm, and a lightning talk/poster from @emmajays.bsky.social Congrats to Emmajay for her 2nd-place poster award too!

#ASMS2025 Come here about the latest in real-time instrument control including applications to single cell proteomics (@parallelsq.bsky.social), #glycotime, and quantitative proteomics!

Nick Riley@nmriley.bsky.social · last yr.

#ASMS2025 offers great evening workshops. If you are interested in real-time decision-making during MS data acquisition or still looking for one to join, consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.

#ASMS2025 offers great evening workshops. If you are interested in real-time decision-making during MS data acquisition or still looking for one to join, consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.

Great to see #proudofalumni @nmriley.bsky.social on the @cenmag.bsky.social Talented 12 list! 🎉 🏆 Check out his #glycotime research program: www.riley-research.com

Riley Research Group at UW

Systems glycobiology enabled by innovations in mass spectrometry and chemical biology Glycosylation is a dominant feature of extracellular phenotypes. Glycoproteins present distinct combinations of gl...

riley-research.com

C&EN (Chemical & Engineering News)@cenmag.bsky.social · last yr.

They’re here! Introducing the Talented 12 Class for 2025. These early-career scientists are taking on big global #chemistry challenges. Meet the 2025 Class: cen.acs.org/people/profi... #CENT12 #chemsky🧪

@nmriley.bsky.social of @riley-research.bsky.social is pursuing better ways to study the biochemistry of sugars that decorate cell surfaces. He hopes that someday scientists could analyze these sugars en masse to infer the health of the cell. Read more: cen.acs.org/biological-c... #CENT12 #chemsky🧪

@riley-research.bsky.social is excited for #ASMS2025 in Baltimore! We made sure to capitalize on some of the classics, like a crab dinner at LP Steamers and an Orioles game, before the conference festivities kicked off. Come hear what we have been up to!

We are lucky to have multiple people to celebrate in @riley-research.bsky.social recently. This time graduate student Kayla Markuson won 2 (!) @uwchemistry.bsky.social awards: - Outstanding Teaching Assistant Award - Excellence in Graduate Leadership and Service Award Way to go Kayla!

I still can't quite believe I am included in the 2025 Searle Scholars cohort. Feeling especially thankful for all who have supported me. I am most excited about the science @riley-research.bsky.social gets to pursue and the support this award provides for my group searlescholars.org/2025/04/14/s...

SEARLE SCHOLARS PROGRAM NAMES 15 SCIENTISTS AS SEARLE SCHOLARS FOR 2025

Members of the new class of Searle Scholars pursue ground-breaking research in chemistry and the biomedical sciences. Each receives an award of $300,000 in flexible funding to support his, her, or …

searlescholars.org