Happy #worldimmunizationweek @who.int 💉 This year's campaign, “For every generation, vaccines work”, is a great reminder that #vaccineswork and have saved >150 million lives since 1974❗ In celebration of the life-saving power of vaccines, we spoke with 2 vaccinology experts. Read our Q&A below🔻

Nature Communications@natcomms.nature.com · 5mo ago

It's #WorldImmunizationWeek ! We have spoken with Gagandeep Kang & Teresa Lambe on the life-saving effects of immunisation, growing challenges around misinformation and vaccine hesitancy, and lessons learnt from the COVID-19 pandemic

Out today is this recent work by @josiebryant.bsky.social lab at @sangerinstitute.bsky.social showing body site translocation of Pseudomonas aeruginosa - from the lung 🫁 to the gut - in hospitalised patients. @natcomms.nature.com

Josie Bryant@josiebryant.bsky.social · 11mo ago

Really pleased to share the first paper to come out of the lab. We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung. The phylogenies indicate that the clones moved from lung->gut www.nature.com/articles/s41...

Latest in our #Phage collection Through #experimentalevolution, researchers at @ucsandiego.bsky.social trained #phages to increase their ability to inhibit multidrug-resistant and extensively drug-resistant Klebsiella pneumoniae 🧫 @natcomms.nature.com www.nature.com/articles/s41...

Experimental phage evolution results in expanded host ranges against antibiotic resistant Klebsiella pneumoniae isolates - Nature Communications

Ghatbale et al. adapted a co-evolutionary technique to develop Klebsiella pneumoniae phages to be highly active longitudinally against K. pneumoniae clinical isolates, including drug resistant isolate...

nature.com

Let's talk bacterial wars 🤺 Fresh out of the press is a new review on the #T6SS, with striking imagery and great insights into effector diversity and how this powerful nano weapon shapes #microbialcommunities #bacterialwarfare @springernature.com

Nature Reviews Microbiology@natrevmicro.nature.com · 11mo ago

New online! The type VI secretion system and associated effector proteins

Latest in our #Phages collection 👇 learn how phage and bacteria interact in the honeybee gut🐝 @springernature.com @natcomms.nature.com #bacteriophages www.nature.com/collections/...

Philipp Engel@pengellab.bsky.social · 11mo ago

🐝🦠 New paper: rdcu.be/eOf7A Phages may drive microbial diversity, yet we often don’t even know how phages & bacteria correlate in nature. Our new study tackles this in the honeybee gut, thanks to the great work of PhD student @malickndiaye.bsky.social at @dmf-unil.bsky.social @fbm-unil.bsky.social

📢Attention Phage Phriends 🦠Happy #WorldPhageWeek Check out our cross-journal Collection “Phages: from biology to the clinic”, with the latest on #phagebiology, phage–host interactions & #phagetherapy #PhageResearch #Bacteriophages #NaturePortfolio @natcomms.nature.com @natureportfolio.nature.com

Phages: from biology to the clinic

This cross-journal Collection welcomes manuscripts covering a broad spectrum of research related to phages, including fundamental studies on phage biology and ...

nature.com

Your weekend read VAP is one of the most common hospital-acquired infections, but #phages are here to help 🤝 In a murine model of VAP, the combination of phage and antibiotic therapy led to faster clinical improvement and prevented epithelial cell damage🐁🫁 #phagetherapy #VAP #pneumonia

Nouailles Lab@geraldinen.bsky.social · last yr.

Read our latest #research on #phages #VAP, published with @springernature.com in @natcomms.nature.com. Phages synergize with antibiotics and alleviate ventilator-induced pneumonia. Read more here: rdcu.be/el5ep

Satisfaction during your #PhD is multifactorial. It's not only how *happy* you feel, but how you're supported within your environment. Beyond #funding, quality supervision and a healthy #worklifebalance are essential for students to feel supported and engaged. #PhDlife #PhDstudent #Research

Nature@nature.com · 12mo ago

We asked 3,785 PhD students across 107 countries about their experiences. Where do you think the happiest doctoral candidates were? go.nature.com/3Wzz2lL

In elephant news 🐘 A study led by the University of Surrey shows that a new vaccine can activate the immune system against EEHV, a deadly virus that affects many young African and Asian elephants. Read about their proof-of-concept trial here ⬇️ www.nature.com/articles/s41...

Springer Nature@springernature.com · 12mo ago

One of our top-rated articles on @altmetric.com this past week was published open access in @natcomms.nature.com. Read 'A safe, T cell-inducing heterologous vaccine against elephant endotheliotropic herpesvirus in a proof-of-concept study' here: www.nature.com/articles/s41... #epidemiology #episky

Did you know that the #T4SS can also mediate biofilm formation?🧫 A #Crohnsdisease associated E. coli strain carries a hybrid T4SS that drives pilin polymerization and #biofilm formation, leading to enhanced fitness in the gut. Read about it here ⬇️ @natcomms.nature.com #naturecommunications

Elhenawy lab@waelelhenawy.bsky.social · 12mo ago

Happy to share our latest pub in @natcomms.nature.com led by my trainee Jonas Wong www.nature.com/articles/s41.... We identified an 'unusual' T4SS used by Crohn's E. coli to make biofilms and ⬆️ inflammation. We're hiring a PDF to continue this. Details: iaejup.fa.ocs.oraclecloud.com/hcmUI/Candid...

A fresh of the press with a brilliant accompanying thread! Great work by @aliciapcv.bsky.social and colleagues @cnb-csic.bsky.social 👏 #plasmidbiology

Alicia Calvo-Villamañán@aliciapcv.bsky.social · last yr.

This work is finally published! 🥳🧬 Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14

The mRNA tech strikes *yet* again

Nature@nature.com · last yr.

Two vaccine candidates using mRNA technology elicit a potent immune response against HIV go.nature.com/4ov7WZI

Excited to share our latest work using AI-designed proteins to block heme-piracy by E. coli. Published in @natcomms.nature.com. A team effort between my lab and the ‪‪@knottrna.bsky.social‬ ‬lab, with experimental work led by the talented @danielrfox.bsky.social www.nature.com/articles/s41...

Inhibiting heme piracy by pathogenic Escherichia coli using de novo-designed proteins - Nature Communications

Many pathogens encode transporters that extract heme directly from host proteins. In this study, the authors demonstrate the utility of de novo-designed proteins in understanding the mechanism behind ...

nature.com

I am very happy to share our latest study on ciprofloxacin resistance instability in P. aeruginosa during periods of drug restriction. A fantastic collaboration @pablolaborda.bsky.social, RuggeroLaRosa, JLMartínez, SørenMolin & HelleJohansen 🥳 @cnb-csic.bsky.social www.nature.com/articles/s41...

Ciprofloxacin resistance rapidly declines in nfxB defective clinical strains of Pseudomonas aeruginosa - Nature Communications

Antimicrobial resistance can decline due to compensatory mutations or genetic reversions to wild-type alleles. Here, the authors analyse the decline of ciprofloxacin resistance in nfxB-defective Pseud...

nature.com

The rhetorical question. However, it comes a point when all our spoken languages get jumbled up in our brains and we start speaking a mix of all 😅

The Economist@economist.com · last yr.

Numerous studies have shown that bilinguals undergo a later onset of dementia, perhaps of around four years, on average—though some of these have failed to replicate. The good news is that it is never too late to start learning https://econ.trib.al/weUpnrW

Now published, congrats Bevika, Kinki, Vincent, Florian and Paddy! #MicroSky www.nature.com/articles/s41...

Genome-wide antibiotic-CRISPRi profiling identifies LiaR activation as a strategy to resensitize fluoroquinolone-resistant Streptococcus pneumoniae - Nature Communications

Streptococcus pneumoniae, the causative agent of pneumococcal disease, has become increasingly resistant to fluoroquinolones. Through CRISPRi-seq, the authors identify the role of the LiaFSR operon in...

nature.com

Jan-Willem Veening@veeninglab.com · 2y ago

Checkout this preprint from Bevika Sewgoolam! She used CRISPRi-seq to determine antibiotic-stress signatures, specifically of pneumococci treated with fluoroquinolone antibiotics. It's a really powerful approach revealing a surprising antibiotic combination therapy. www.biorxiv.org/content/10.1...

Very exciting new collection on the clinical #microbiome 🦠

Katrina Ray@heykatray.bsky.social · 2y ago

New collection on the clinical #microbiome from @naturemedicine.bsky.social @naturemicrobiol.bsky.social @naturecomms.bsky.social @commsmed.bsky.social open for submissions! More info on how to submit here www.nature.com/collections/... #Gastrosky #microsky 🧪