The pleasure isn't in being right. It's in the finding out.
David Landeira
@davidlandeira.bsky.social
Cells forget. We’re learning how to make them remember. @GENYO University of Granada, Spain. www.landeiralab.ugr.es
Perspective @naturerevgenet.bsky.social @nireynon.bsky.social Embracing non-linearity in human ageing www.nature.com/articles/s41...
Embracing non-linearity in human ageing - Nature Reviews Genetics
Ageing has often been conceptualized as a gradual, linear decline, yet growing evidence suggests it unfolds through dynamic, stage-specific transitions. In this Perspective, the authors examine such e...
nature.com
Our latest is now out in @nataging.nature.com giving reason to celebrate! Led by talented Spiros Palikyras, it improves our preprint (posted 2 years ago!) dissecting the mechanism and functional consequences of CTCF clustering upon senescence commitment of human cells. www.nature.com/articles/s43...
Senescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program - Nature Aging
Palikyras and colleagues investigate chromatin reorganization upon senescence induction, reporting that components of nuclear speckles coordinate chromatin rewiring and a senescence-associated splicin...
nature.com
Nos hacen notar desde el Ministerio @cienciagob.bsky.social que desde el 2018 ha habido una subida de presupuesto del 40%. Sin duda, desde que entró este gobierno la subida ha sido notable. Pero amigos... ¡es que nos hemos estancado! ¡Y la Ciencia sigue! @ageinves.bsky.social
Jose A. Esteban@jaestebancbm.bsky.social · 3w agoY si queréis ver la tendencia de los últimos años: - Está subiendo mucho el número de solicitudes (casi un 10% respecto al año pasado). - La financiación total no sube al mismo ritmo (un 5,7%). - La financiación media por proyecto se mantiene. - Conclusión: se rechazan más proyectos.
La financiación de los proyectos de investigación se está estancando. ¡Pero la ciencia no se para! Si no se hace aquí, se hará en otra parte... 😕 elpais.com/ciencia/2026...
¿Qué ciencia puede realizarse con 50.000 euros al año?
“Esta limitación presupuestaria dificulta afrontar los experimentos complejos que hoy exige buena parte de la investigación en múltiples campos”, denuncian los autores
elpais.com
Tribuna con @xrbustelo.bsky.social, @jaestebancbm.bsky.social, JM Torralba y J Gil sobre la resolución provisional de los proyectos PID (“Plan Nacional”), con media de 50.000 euros/proyecto/año (costes directos). Hay otras convocatorias, pero esta es básica e insuficiente elpais.com/ciencia/2026...
¿Qué ciencia puede realizarse con 50.000 euros al año?
“Esta limitación presupuestaria dificulta afrontar los experimentos complejos que hoy exige buena parte de la investigación en múltiples campos”, denuncian los autores
elpais.com
1/2 The Immunity by Design: In Vivo Immune Cell Engineering Conference introduces Session 1: Cell Engineering & Reprogramming. The Pereira lab will share the stage with Judit Svensson Arvelund and Özcan Met to discuss emerging approaches in immune cell engineering and cancer immunotherapy.
Our new review in @cp-trendscellbio.bsky.social is now online! We discuss the connection between the epigenome, 3D genome folding, gene expression and cellular memory, specifically in loop extrusion-independent contexts.
Trends in Cell Biology@cp-trendscellbio.bsky.social · last yr.3D genome folding in epigenetic regulation and cellular memory
The list of speakers is very nice, mixing the two fields in synergy. Many abstracts will be selected for oral presentation.
Pablo Navarro@pablonavarrolab.bsky.social · 2mo agoEpigenetics means different things for different people. In this workshop we will discuss two major views anchored on transcriptional memory: chromatin vs networks. Come and share with us our excitement for the topic and the magnificent place, the Andalusian Baeza. urldefense.com/v3/__https:/...
"The goal is not just more capable AI, but AI that is more intelligible, accountable, and aligned with human aims. The window for achieving that future is narrowing," argue Eric Horvitz and Robert West in a new #ScienceEditorial. https://scim.ag/4oaIYig
🚨 New paper in Nature 🚨 Thrilled to be part of this fascinating collaborative study! 👉 SIRT7 regulates dosage compensation and safeguards the female X chromosome rdcu.be/fnEZQ A great example of how chromatin regulation continues to reveal unexpected layers of genome control!
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Nature - SIRT7 safeguards X-chromosome integrity and dosage balance with autosomes.
rdcu.be
Excited to announce the International Workshop "Transcriptional memory in health & disease" in Baeza (Spain) this Oct 20-22! Discover how chromatin & networks encode cellular memory with top speakers. unia.es/estudios-y-a... pic.x.com/fjhBUrtRgb
If you cannot explain it in simple terms, you don't understand it well enough.
"I would like to emphasize the importance of question-driven science...young scientists might enjoy science more if they are thinking about questions rather than just collecting data" journals.biologists.com/jcs/article/...
Interview with Noboru Mizushima – President of the Japan Society for Cell Biology
Noboru Mizushima is Professor of Biochemistry and Molecular Biology at the University of Tokyo, Japan, where he runs a laboratory studying the mechanisms and physiological functions of autophagy and o...
journals.biologists.com
Nature research paper: Dogs were widely distributed across western Eurasia during the Palaeolithic go.nature.com/3NNGybD
Dogs were widely distributed across western Eurasia during the Palaeolithic - Nature
Analysis of nuclear and mitochondrial genomes from archaeological canid remains found across Europe and Anatolia shows that a genetically homogeneous dog population was already widely distributed across the region by 15,000 years ago.
go.nature.com
The rates of more than a dozen cancers are increasing among adults under the age of 50. What are the reasons behind it? go.nature.com/4cKxhLN
Why are so many young people getting cancer? What the data say
Clues to a modern mystery could be lurking in information collected generations ago.
go.nature.com
We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).
Graphical abstract from our new paper in Nucleic Acids Research with @saramaciasrna.bsky.social 🧬 DGCR8 prevents accumulation of endogenous dsRNA derived from Alu elements within mRNAs, avoiding aberrant activation of the interferon response. academic.oup.com/nar/article/...
Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8
Abstract. The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prev
academic.oup.com
muyinteresante.okdiario.com/ciencia/para...
Científicos, Influencers y la paradoja de la confianza: por qué cuanto más rigurosa es la ciencia, menos creemos en ella
¿Por qué confiamos antes en el consejo de un extraño en TikTok que en una institución médica centenaria? Un profundo análisis publicado en The Lancet revela que el rigor científico está perdiendo la b...
muyinteresante.okdiario.com
¿Quieres descifrar los mecanismos epigenéticos del rejuvenecimiento celular? Si tienes un expediente académico superior a 8.5 y buscas realizar tu tesis doctoral en un entorno de excelencia (GENYO, Granada), contáctanos para solicitar becas FPU/Junta. Deadline inminente! ⏩
"Freezing forgetting in C. elegans to extend memory retention" - check out the "research briefing" about our new paper in Nature Neuro rdcu.be/eYlXY
Client Challenge
rdcu.be
New Year, New Paper!🎊 Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system www.biorxiv.org/content/10.6... Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧵
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
Transposable elements (TEs) make up about half of the human and mouse genomes and play important regulatory roles in immune responses. However, the cis -regulatory contribution of TEs to immune cell d...
biorxiv.org
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...
SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
biorxiv.org
OFERTA DE EMPLEO (por favor difundir): Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas 👇
NIH Director Jay Bhattacharya has struggled to convince observers he has the agency’s best interests in mind—and is truly in charge. https://scim.ag/3MMXDSh
Will NIH’s new director reform his agency—or destroy it?
Jay Bhattacharya is struggling to make the case he’s in charge and has the agency’s best interests at heart
scim.ag
Congrats to @allanaschooley.bsky.social et al. @jobdekker.bsky.social on this beautiful paper, using a very elegant experimental system, to discover a chromosome intrinsic 3D genome folding program and microcompartmentalization of CREs at mitotic exit:
Job Dekker@jobdekker.bsky.social · 8mo agoExciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm! www.nature.com/articles/s41...
🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜 www.science.org/doi/epdf/10....
CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency, and cell death
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science.org
Michelle Percharde@mpercharde.bsky.social · 2y agoHappy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)
Be sure to also check out the great paper from @andersshansen.bsky.social and colleagues where they discover microcompartments on mitotic chromosomes using Region Capture Micro-C. Exciting times for those interested in chromosome conformation during cell division! www.nature.com/articles/s41...
Dynamics of microcompartment formation at the mitosis-to-G1 transition - Nature Structural & Molecular Biology
Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and promoters in prometaphase. Polymer modeling in...
nature.com