Rob Parton

@robparton.bsky.social

Molecular cell biology, electron microscopy. Endocytosis, caveolae, lipid droplets, nanoparticles. Cultured cells, zebrafish, tardigrades.

First day back at work for 2026, and excited to share that @gurgaganveer's first paper from his PhD has been published in @acsnano! If you are interested in the biology of endosomal escape & strategies for enhanced delivery of therapeutics, check it out: bit.ly/4roRcnp

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Do you want to know more about how Retromer regulates Rab7 activity in yeast? Of course you do. Check out the new collaboration with Andreas Mayer with work led by Catarina Alves and Kevin Chen.

The GTPase activating protein Gyp6 binds Retromer and inactivates Rab7/Ypt7 to coordinate the formation of endosomal carriers

The Retromer coat is conserved in all eukaryotes and is crucial for the correct intracellular sorting of many transmembrane receptors and lysosomal hydrolases. Retromer is an effector of the late endosomal small GTPase RAB7 and is also implicated in its inactivation required for proper endosomal maturation. Here, we explore the role of controlled GTP hydrolysis by the RAB7 ortholog Ypt7 in the formation of Retromer-coated membrane carriers in yeast. Proximity labelling and genetic ablation identify the GTPase Activating Protein (GAP) Gyp6 as a critical regulator of Ypt7 activity in the context or Retromer. Structural studies show that Retromer recruits Gyp6 through its Vps29 subunit, which recognises a specific PL motif and a secondary binding site in the C-terminal domain of Gyp6. This interaction does not occur with other yeast GAPs. Ablation of the Gyp6-Retromer interface or the catalytic activity of Gyp6 leads to the accumulation of tubular structures on endo-lysosomal compartments and to increased association of Ypt7 with Retromer and its cargo Vps10. These results support a model in which Gyp6 controls the switch from Ypt7-dependent Retromer coat assembly and cargo collection to the departure of the carrier through membrane fission and uncoating. ### Competing Interest Statement The authors have declared no competing interest. National Health and Medical Research Council, https://ror.org/011kf5r70, APP2016410 Swiss National Science Foundation, https://ror.org/00yjd3n13, 31003A_179306, 310030_204713, 10.006.083

biorxiv.org

Latest issue of Cowrent Biology is up! www.cell.com/current-biol...

Current issue: Current Biology

cell.com

Alice Auersperg@auersperga.bsky.social · 7mo ago

Our new paper (with @biotay.bsky.social) is out and on the cover story of @currentbiology.bsky.social !!!! Veronika, a Carinthian mountain cow flexibly uses a “multi-purpose tool” to scratch herself. A video and more information will follow in the comments. www.cell.com/current-biol...

The Institute for Molecular Bioscience is seeking an exceptional academic leader to be the new Director of the Centre for Chemistry and Drug Discovery and lead our centre consisting of 10 group leaders, 40 staff and approximately 50 HDR students. Come and join us in sunny Brisbane!

Director, Centre for Chemistry and Drug Discovery

Institute for Molecular Bioscience Join a university ranked in the world’s top 50 Australia’s #1 research institute Based at St Lucia Campus About UQ What started as Queensland's first university in 1...

uq.wd3.myworkdayjobs.com

'The study...found that the main driver of increased red tape was university efficiency reforms. It threw doubt on the idea that increasing automation results in real efficiency, and suggested that Australian universities...had recently shifted towards stronger central executive management.' 1/2

Research Professional News@resprofnews.bsky.social · 11mo ago

University efficiency drives may have opposite effect, study finds. The administrative burden in Australian universities is most keenly felt by teaching and research staff, according to a study from the University of Melbourne’s faculty of education. www.researchprofessionalnews.com/rr-news-aust...