#Astrocytes activate in ordered sequences during #learning and #recall. In PNAS Journal Club: https://ow.ly/qOWr50ZY7yM #memory #neuron #hippocampus

Glia gang, this is for you! In this video by our #ElectronMicroscopy team, shows a pyramidal neuron (PyC) surrounded by 8 glia brain cells – 5 microglia (MG) and 3 oligodendrocyte progenitor cells (OPC). 🧠📈 http://microns-explorer.org

how does memory support perceptual decisions made under uncertainty? this question has scaffolded my entire PhD, and I'm so excited to share part of it in this ✨new preprint ✨ w/ @meganakpeters.bsky.social and @aaronbornstein.bsky.social! link: www.biorxiv.org/content/10.6...

Memory retrieval explains dynamic effects of expectations on perceptual decisions

Expectations—prior knowledge of environmental statistics—support adaptive behavior by reducing uncertainty during inference. However, the questions of where expectations come from and how that ought t...

biorxiv.org

My lab is recruiting a postdoctoral researcher! Interested in astrocyte transcriptional regulation and addiction? We study how astrocytic transcriptional, epigenetic, and chromatin regulation contributes to substance abuse disorders. DM or email me! www.l-holt-lab.com

Check out our lab’s new work on astrocytic temporal structure in fear learning and memory with co-author @ryguy.io and collaborators Marc Howard and Rui Cao! Stay tuned for more work following up on this study! ⭐️

Steve Ramirez@okaysteve.bsky.social · last mo.

🚨 new work from the lab! "Hippocampal astrocytic sequences emerge during learning and memory recall" by @ryguy.io & @rsuthard.bsky.social thank you to the entire team for your camaraderie and for muscling through science together 🧠 -- we welcome all feedback! nature.com/articles/s41...

Check out my latest work from the Ramirez lab with co-author @rsuthard.bsky.social! It’s got astrocytes—what more do you need!?

Steve Ramirez@okaysteve.bsky.social · last mo.

🚨 new work from the lab! "Hippocampal astrocytic sequences emerge during learning and memory recall" by @ryguy.io & @rsuthard.bsky.social thank you to the entire team for your camaraderie and for muscling through science together 🧠 -- we welcome all feedback! nature.com/articles/s41...

Move over, GLM-HMM—there’s a new hidden Markov model in town. In our new preprint, we introduce the DDM-HMM: a model that jointly infers latent decision states from reaction times and choices. Using 24-hour behavioral data from rats, we found that evidence accumulation changes with time of day!

bioRxivpreprint@biorxivpreprint.bsky.social · 5mo ago

Diurnal rhythms of choice: a novel state-dependent drift diffusion model uncovers time-dependent changes in rat decision making https://www.biorxiv.org/content/10.64898/2026.05.25.727672v1

Astrocytes do so much more than any of us thought - they even communicate among specific brain regions across hemispheres! The journey to this paper spanned nearly a decade, but I'm most excited to see what everyone else does with the tools we've built. There's so much for all of us to explore!

Astrocytes connect specific brain regions through plastic networks - Nature

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

nature.com

A Distinct Layer 1 Astrocyte Program Shapes Perisynaptic Structure and Calcium Signaling in Mouse Motor Cortex https://www.biorxiv.org/content/10.64898/2026.03.16.712002v1

Excited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with @sianduss.bsky.social @bohaceklab.bsky.social, and many others: www.biorxiv.org/content/10.6... 1/5

Thrilled to wrap up the year and my postdoc work in the Nester lab with this publication 🥳! We show that astrocytic CREB regulates astrocyte calcium and D1-MSN activity to drive behavioral response to cocaine. pubmed.ncbi.nlm.nih.gov/41406210/

🚨🚨🚨NEW PAPER ALERT🚨🚨🚨 We present StateSpaceDynamics.jl, an open-source Julia package for fitting probabilistic state-space models (SSMs)—including non-conjugate models like Poisson LDS and switching variants (SLDS). Python has had existing packages that have given this functionality...

Journal of Open Source Software@joss-openjournals.bsky.social · 12mo ago

Just published in JOSS: 'StateSpaceDynamics.jl: A Julia package for probabilistic state space models (SSMs)' https://doi.org/10.21105/joss.08077

check out the @okaysteve.bsky.social lab’s posters (for both neuron and glia enthusiasts) at #SfN2025 on Saturday PM! especially say hello to @siriacoello.bsky.social who is applying to grad school this cycle✨

thanks so much for hosting me, looking forward to sharing my work! 

The Friedman Brain Institute@sinaibrain.bsky.social · last yr.

On November 7th, DON'T MISS @bostonu.bsky.social's Dr. Rebecca Suthard when she JOINS #MSNSeminars. Hosted by Drs. Brian Kipp, Chloe Lopez-Lee and Rimjhim Tomar, Dr. Suthard will present “A hippocampal astrocytic sequence emerges during learning and memory". @mountsinainyc.bsky.social

Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8

Evidence for the Transient Presence of Atypical Astrocytes in Mice Following a Single, Closed-Head Mild Traumatic Brain Injury https://www.biorxiv.org/content/10.1101/2025.09.16.676600v1

90% of neuroscience papers are one of: 1. it turns out what we thought was generally true was actually just a special case 2. the thing we think is true contains smaller things that we can measure 3. what we thought was true is still true, but now with lasers pew pew

This is why science funding matters. We uncovered a hidden signaling system in the brain—one that responds to maternal environment, even to drugs like LSD during pregnancy. It took 5 years, a brilliant team, and public funding to get here. Out today in @NatureNeuro: 🧵👇

@lehtinenlab.bsky.social · last yr.

Led by @scienceyael.bsky.social & out today in @natneuro.nature.com: the brain's fluid-secreting organ — the choroid plexus — can reshape neural development through a powerful, little-known process. & it can be hijacked by serotonergic drugs like LSD. 🧠👇 A thread rdcu.be/eoaSY

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation. rdcu.be/el18q A short thread follows for those interested. 1/n

Systems consolidation reorganizes hippocampal engram circuitry

Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...

rdcu.be

HEY BOSTON! 📣☀️ MARCH 7TH, MASSACHUSETTS STATE CAPITOL! Join us to #standupforscience2025 and make your voice heard! SEE YOU THERE! www.standupforscience2025.org #standupforscience20225

Shared some of my recent experiences and thoughts with @callimcflurry.bsky.social of @thetransmitter.bsky.social. In these chaotic times, it’s important that there’s an ability for voices to be heard. I’m very thankful to Calli and The Transmitter for the opportunity.

The Transmitter @thetransmitter.bsky.social · 2y ago

Over the past few weeks, science funding in the U.S. has become shrouded in uncertainty. Ten trainees with diversity-based funding share how the changes are affecting their research and career plans. By @avaskham.bsky.social @claudia-lopez.bsky.social @callimcflurry.bsky.social bit.ly/42Wifxr

if you listen closely, you can hear the sound of every scientist in the US screaming

Delighted to share an update to our preprint, reviewed at @elife.bsky.social, and now sent back for re-review. Colossal work by the team and driven home by @mathiasgua.bsky.social Quick 🧵 of what's new - www.biorxiv.org/content/10.1...

Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation

Early-life stress can have lifelong consequences, enhancing stress susceptibility and resulting in behavioural and cognitive deficits. While the effects of early-life stress on neuronal function have ...

biorxiv.org