Look out for this event! Focussed on creating change and trading experiences and ideas about positive research culture for LGBTQ+ people working in STEM.

Queer in STEM Workshop@queerstemworkshop.bsky.social · 2mo ago

Registration is now open for the LGBTQ+ in STEM Workshop! 22nd-23rd September, Cambridge. Exciting speaker line-up, with subsidised accommodation and travel bursaries. Come along, share your experiences of being queer in STEM www.outsavvy.com/event/35459/...

Registration is now open for the LGBTQ+ in STEM Workshop! 22nd-23rd September, Cambridge. Excellent speaker line-up confirmed, with subsidised accommodation and travel bursaries. Come down, share your experiences of being queer in STEM www.outsavvy.com/event/35459/... @lgbtqstemworkshop.bsky.social

Excited to share some recent work tracking the 3D movement of individual molecules inside the organelles of living cells (💡+ 🦠 + ⚽️💨) with the best team @joechambers.bsky.social @jamesdmanton.bsky.social @jsbeckwith.bsky.social @dgershlick.bsky.social @stevethechemist.bsky.social

bioRxiv Biophysics@biorxiv-biophys.bsky.social · last yr.

Volumetric single-molecule tracking inside subcellular structures https://www.biorxiv.org/content/10.1101/2025.06.09.658280v1

Big big thanks to all CMM participants & sponsors #CMM2025

CMM 2025 day 1

Day 2 of #CMM2025! We're kicking off the first session with our third invited speaker Prof Tuomas Knowles presenting on "Probing protein self-assembly and phase transitions using microfluidics". @cmicrosocpymeeting.bsky.social

Let's get the hashtag #CMM2025 for CMM2025 (@cmicrosocpymeeting.bsky.social) to get the discussion rolling!

We’re busy setting up for Cambridge Microcopy Meeting 2025 this week! Looking forward to exciting talks, but first setting up space for sponsor exhibits! #cmm2025 @cmicrosocpymeeting.bsky.social @jsbeckwith.bsky.social @chemlibcam.bsky.social

We’re thrilled to announce our exhibition, Space: Could Life Exist Beyond Earth?, opening 16 May 2025. 🚀 Rooted in the latest cutting-edge scientific research from the Museum, the exhibition will uncover evidence that life could exist beyond our planet.

By putting a donut between our faces and each article we read, we were able to extract more information than ever before about MINFLUX. You can read the new review article from @maxperutzlabs.bsky.social by Lukas Scheiderer, myself, and @jonasries.bsky.social at www.nature.com/articles/s41...

MINFLUX achieves molecular resolution with minimal photons - Nature Photonics

The authors review MINFLUX super-resolution microscopy, outlining its advantages and limitations, recent progress, and an outlook for future developments.

nature.com

Excited to see that my first, first author paper out of my PhD was selected among the Top 25 Physics Research papers of 2024 by Nature Communications! @naturecomms.bsky.social www.nature.com/articles/s41...

High-density volumetric super-resolution microscopy - Nature Communications

Current approaches for volumetric super-resolution microscopy can yield large and complex PSF spatial footprints. Here, the authors show a super-resolution microscopy approach using a hexagonal microl...

nature.com

If you're interested in advanced 3D super-resolution microscopy then there is an exciting new job opportunity in TheLeeLab here in Cambridge. Happy to answer any questions! 🔬🧪🦠 www.jobs.cam.ac.uk/job/50547/

“I make a lot less than I made in the US, and I wasn’t even head of an institution in the US, right?” That yearly salary could fund over 30 PhDs… that’s our problem. www.theguardian.com/education/20...

Cambridge risks losing ‘unbelievable talent’ amid PhD funding cut

Warning by vice-chancellor Deborah Prentice comes as ‘Silicon Valley’ planned between Oxford and Cambridge

theguardian.com

does anyone know of good repositories for (e.g.) nice scalable vector graphics of a microscope objective? Or have a nice svg they'd be willing to part with? @hohlbeinlab.bsky.social @jamesdmanton.bsky.social @samofmidworld.bsky.social #chemsky #microscopy

First panic attack of the year! Managed to make it until the 6th Jan—good going Sam!

Was I there? Yes. Am I still immensely excited for 4:10? Yes!

Have a go at these 24 FREE #FestiveScience activities from #DrJoScience and share what you get up to! #ScienceIsEverywhere #BeCurious #STEMActivities #Advent #AdventCalendar #PrimaryScience bio.link/DrJoScience

Single molecule nerds come work with us! www.jobs.cam.ac.uk/job/49742/

First paper out of my postdoc has just dropped! We map the 3D spatial relationship of PSD95 in mouse brain using DHPSF super-resolution microscopy… and in just enough time for the last #FluorescenceFriday before Christmas! 🎄 pubs.acs.org/doi/10.1021/...

3D Super-Resolution Imaging of PSD95 Reveals an Abundance of Diffuse Protein Supercomplexes in the Mouse Brain

PSD95 is an abundant scaffolding protein that assembles multiprotein complexes controlling synaptic physiology and behavior. Confocal microscopy has previously shown that PSD95 is enriched in the postsynaptic terminals of excitatory synapses and two-dimensional (2D) super-resolution microscopy further revealed that it forms nanoclusters. In this study, we utilized three-dimensional (3D) super-resolution microscopy to examine the nanoarchitecture of PSD95 in the mouse brain, characterizing the spatial arrangement of over 8 million molecules. While we were able to identify molecular arrangements that have been previously reported, imaging in 3D allowed us to classify these with higher accuracy. Furthermore, 3D super-resolution microscopy enabled the quantification of protein levels, revealing that an abundance of PSD95 molecules existed outside of synapses as a diffuse population of supercomplexes, containing multiple copies of PSD95. Further analysis of the supercomplexes containing two units identified two populations: one that had PSD95 molecules separated by 39 ± 2 nm, and a second with a separation of 94 ± 27 nm. The finding that there exists supercomplexes containing two PSD95 units outside of the synapse suggests that supercomplexes containing multiple protein copies assemble outside the synapse and then integrate into the synapse to form a supramolecular nanocluster architecture.

pubs.acs.org

Excited to attend (my first proper biology conference at) UK Membrane Trafficking Meeting! With @dgershlick.bsky.social @awolowczyk.bsky.social @joechambers.bsky.social

Please share, we have #PhD opportunities for anyone interested in filming the #Biophysics of life at the nanoscale. Full details at: heath-afm-lab.github.io/positions/ Projects based around developing and applying High-Speed Atomic Force Microscopy methods to understand molecular dynamics.

An early Christmas present if you like Fluorescence Lifetime Imaging Microscopy, data analysis and pho-ho-ho-tons (sorry not sorry) - another postdoc position open in my group! Deadline 16th December -> www.kcl.ac.uk/jobs/100785-... Part of a super fun and collaborative Wellcome Bioimaging project 🔬

Another PhD opportunity- This time with Ivana Barbaric in Biosciences….come join us to play on this bit of kit! www.findaphd.com/phds/project...

Wait what? Why!!!

Reactor Magazine@reactorsff.bsky.social · 2y ago

The live-action teaser of How to Train Your Dragon shows us a Hiccup and Toothless moment close the original animated film: reactormag.com/how-to-train...

Hullooooo Cell Biology friends. If you're heading to #CellBio2024 in (hopefully!) sunny San Diego this year, then come and check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! See you there! **Please RT** 🥳

There's just over a fortnight left to apply to the LMB's PhD programme, which features a veritable smörgåsbord of projects (including one of our own on engineering the next generation of fluorescent proteins for live and super-resolution microscopy). www2.mrc-lmb.cam.ac.uk/students/int...

My first custom microlens array from PowerPhotonic to do some exciting light field microscopy over the coming weeks!

Exciting new preprint just dropped by the Lee lab! Using 3D super-resolution microscopy to map the distribution of protein PSD95 in brain tissue. www.biorxiv.org/content/10.1...

3D super-resolution imaging of PSD95 reveals an abundance of diffuse protein supercomplexes in the mouse brain

PSD95 is an abundant scaffolding protein that assembles multiprotein complexes controlling synaptic physiology and behavior. Confocal microscopy has previously shown that PSD95 is enriched in the post...

biorxiv.org