Excited for start of AAIC! I’ll be giving talk Tuesday afternoon on unique population of AD-relevant macrophages we have identified in CSF via scRNA-seq: 𝗦𝗶𝗻𝗴𝗹𝗲 𝗖𝗲𝗹𝗹 𝗧𝗿𝗮𝗻𝘀𝗰𝗿𝗶𝗽𝘁𝗼𝗺𝗶𝗰𝘀 𝗼𝗳 𝗣𝗮𝗶𝗿𝗲𝗱 𝗖𝗦𝗙 𝗮𝗻𝗱 𝗕𝗹𝗼𝗼𝗱 𝗜𝗺𝗺𝘂𝗻𝗲 𝗣𝗼𝗽𝘂𝗹𝗮𝘁𝗶𝗼𝗻𝘀 𝗥𝗲𝘃𝗲𝗮𝗹𝘀 𝗨𝗻𝗶𝗾𝘂𝗲 𝗠𝗮𝗰𝗿𝗼𝗽𝗵𝗮𝗴𝗲 𝗣𝗼𝗽𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝘄𝗶𝘁𝗵 𝗥𝗲𝗹𝗲𝘃𝗮𝗻𝗰𝗲 𝘁𝗼 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿'𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲

scCustomize 3.0.1 now on CRAN. Hotfix release with couple of bug fixes. Enjoy!

Samuel Marsh Ph.D.@samuelmarsh.bsky.social · 2y ago

🚨 scCustomize v3.0.0 is released! 🚨 Lots of changes (see thread for highlights and changelog for full details). Thanks as always to everyone who has submitted bug reports or suggestions and thanks to everyone using the package!! Enjoy! 😀💻📈🧬 cran.r-project.org/web/packages... 1/n

Implementation and validation of single-cell genomics experiments in neuroscience www.nature.com/articles/s41... Validation is key! This review dives into best practices for validating ssc/snRNAseq experiments. Learn about the challenges and solutions for ensuring robust and reliable findings.

a cartoon character is holding a can of beans with the words how do i use it below him

ALT: a cartoon character is holding a can of beans with the words how do i use it below him

media.tenor.com

3 reviews on planning, execution, & validation of transcriptomic experiments in neuroscience published in @natureportfolio.bsky.social #NatureNeuroscience. A MUST READ if you're doing transcriptomics. 3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year! (mini thread)

🚨 scCustomize v3.0.0 is released! 🚨 Lots of changes (see thread for highlights and changelog for full details). Thanks as always to everyone who has submitted bug reports or suggestions and thanks to everyone using the package!! Enjoy! 😀💻📈🧬 cran.r-project.org/web/packages... 1/n

scCustomize: Custom Visualizations & Functions for Streamlined Analyses of Single Cell Sequencing

Collection of functions created and/or curated to aid in the visualization and analysis of single-cell data using 'R'. 'scCustomize' aims to provide 1) Customized visualizations for aid in ease of use...

cran.r-project.org

So excited to share our work developing a new class of modular synthetic GPCRs, out today @Nature! Check it out nature.com/articles/s41...

Synthetic GPCRs for programmable sensing and control of cell behaviour - Nature

Modular synthetic G-protein-coupled receptors with nanobody-based ligand-recognition domains can be designed and used to programme transgene expression, real-time fluorescence or endogenous G-protein ...

nature.com

Alice Ting@aliceyting.bsky.social · 2y ago

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

Spotlight on Single-Cell Genomics! I, Omer Ali Bayraktar, Naomi Habib, Genevieve Konopka, @liddelowsa.bsky.social, and Tomasz Nowakowski collaborating with top neuroscientists to explore optimizing these technologies in the latest Nature Neuroscience issue. 🔗 www.nature.com/neuro/volume...

The December issue of Nature Neuroscience is now live, featuring our Focus on Single-Cell Genomics! We hope that these consensus reviews from experts in the field will serve as a useful guide for neuroscientists regarding best practices for these approaches. www.nature.com/neuro/volume...

Big day for single cell and neuroscience. Trio of single cell perspective pieces discussing applications, opportunities, challenges, and validation of single cell and spatial genomics in neuroscience are out now in Nature Neuroscience. Links in thread below.👇 1/n

Hello to all new and old friends over here! For those who are new I’m postdoc in Beth Stevens lab studying neuroimmune mechanisms in neurodegeneration using single cell genomics. For more about my work you can check out my website (includes free access to all publications). samuel-marsh.science

who knew it would be easier to get everyone to switch social media platforms than getting them to use hg38

go.bsky.app/Lyzro3M !WELCOME! thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list. apologies for missing many of you - please do reply to get added and remember to repost so the newbies can find us!

Lysosomes cell autonomously regulate myeloid cell states and immune responses https://www.biorxiv.org/content/10.1101/2024.11.11.623074v1

Lysosomes cell autonomously regulate myeloid cell states and immune responses https://www.biorxiv.org/content/10.1101/2024.11.11.623074v1

Myeloid cells maintain tissue homeostasis via the recognition, engulfment, and lysosomal clearance o

biorxiv.org

Ok here we go first BlueSky post/thread! 🚨scCustomize v2.0.0 is released! 🚨 cran.rstudio.com/web/packages... Lots of changes (see thread for highlights & changelog for full details). Thanks as always to everyone who has submitted bug reports & thanks to everyone using the package!! Enjoy! 1/n

Muzz Haniffa’s group with yet another landmark paper on the yolk sac, hematopoiesis, and organogenesis (as well as its differences between humans and mice). Not bad for an alleged dermatologist (yes, I know, skin GvHD… but still!) www.science.org/doi/full/10....

And there's more: @biorxiv-molbio.bsky.social @biorxiv-immuno.bsky.social @biorxiv-physio.bsky.social @biorxiv-sysbio.bsky.social Thanks to all who donated codes 🙏

Richard Sever@richardsever.bsky.social · 3y ago

The cavalry arrives @biorxiv-evobio.bsky.social @biorxiv-neursci.bsky.social @biorxiv-biophys.bsky.social @biorxiv-genetic.bsky.social @biorxiv-cancer.bsky.social @biorxiv-cellbio.bsky.social @biorxiv-ecology.bsky.social @biorxiv-microbiol.bsky.social

The cavalry arrives @biorxiv-evobio.bsky.social @biorxiv-neursci.bsky.social @biorxiv-biophys.bsky.social @biorxiv-genetic.bsky.social @biorxiv-cancer.bsky.social @biorxiv-cellbio.bsky.social @biorxiv-ecology.bsky.social @biorxiv-microbiol.bsky.social