🚨 New paper out! We show that nuclear metabolism is NOT static, it oscillates with the cell cycle. 🔗 advanced.onlinelibrary.wiley.com/doi/10.1002/... #epigenetics #metabolism #cellcycle #chromatin

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase-specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol me...

advanced.onlinelibrary.wiley.com

New paper out in Nature Communications: www.nature.com/articles/s41... We found >250 metabolic enzymes on chromatin. Only ~20 had been reported before. This means hundreds of metabolic enzymes may have unexplored nuclear roles.

Native chromatome profiling reveals hundreds of metabolic enzymes in the nucleus across tissues - Nature Communications

Here proteomic chromatome analysis shows metabolic enzymes widely localize to chromatin in cancer in a tissue-specific manner. Nuclear enzymes affect DNA damage/repair and transcription, revealing non...

nature.com

And then our first PhD student wins the award for Best Thesis of the Year… a wonderful Christmas present 🎄✨ It really makes us feel we’re doing things the right way. Congratulations, Dr. Natalia Pardo Lorente, so well deserved 👏🎓 @crg.eu @upf.edu @prbb.org

Big congrats to Sara Sdelci @sdelcilab.bsky.social for being as one of the 2025 @embo.org Young Investigators (YIPs), joining 28 outstanding early-career scientists recognised for excellence and originality in the life sciences. She is the eighth CRG scientist to join the prestigious programme!

I am (Sara Sdelci, @crg.eu) very happy to have been selected as an @embo.org YIP! Thank you for selecting our project on how nuclear metabolism shapes cellular proliferation and aging; we are truly excited for the beautiful science ahead!

EMBO@embo.org · 8mo ago

Congratulations to the new cohort of 28 EMBO Young Investigators! They are joining an international network of more than 800 life scientists – Welcome! Read the press release here: https://www.embo.org/press-releases/twenty-eight-group-leaders-become-embo-young-investigators/

Dr. Jane Goodall has passed away. Her groundbreaking work with chimpanzees and her lifelong dedication to conservation changed how we see and care for our planet.

Science Magazine@science.org · 10mo ago

Jane Goodall has died at the age of 91. In 2020, Goodall spoke with Science Editor-in-Chief H. Holden Thorp for a #ScienceEditorial reflecting on the 60th anniversary of her arrival in Gombe to study wild chimpanzees. Read more: https://scim.ag/472Chb8

Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life. www.nature.com/articles/s41...

Science: only when you write up the manuscript, you realize what you should have done.

Being open to new ideas: Metabolic Enzymes in the Nucleus as Chromatin Instructors? Merging #chromatin #epigenetics #metabolism To understand new cellular rules.

Itai Yanai@itaiyanai.bsky.social · last yr.

90% of doing science is being open to new ideas.

🚀 We’re excited to share our latest publication in collaboration with Verena Ruprecht's group at @crg.eu Mechanobiology meets Nuclear Metabolism www.nature.com/articles/s41...

Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects - Nature Communications

The authors uncover a mechano-metabolic adaptation where confinement induces rapid mitochondrial relocalization to the nuclear periphery, generating localized nuclear ATP surges that support chromatin...

nature.com

Fantastic to see this wonderful piece out! Happy to have contributed to this effort 💪

Kevin Drew@ksdrew.bsky.social · last yr.

Very excited that our work describing hu.MAP3.0 is published in @molsystbiol.org. Here we use machine learning to integrate >25k mass spectrometry experiments to place ~70% of human proteins into 15k protein complexes. www.embopress.org/doi/full/10....

🔬 ¡Buscamos Técnico/a de laboratorio! 📋 Mantenimiento de colonia, procesamiento de muestras y más. 📍 Barcelona 📩+info: hospitalsantjoandedeu.talentclue.com/es/node/1129... Please RT!

As promised, here is our NEW preprint on CELL CYCLE ASSOCIATED PIP2 NUCLEAR METABOLISM by our SUPER postdoc Toni Gañez, who knows all the secrets of FUCCI reporters 👇 www.biorxiv.org/content/10.1...

Merry Christmas from the Sdelci Lab! Stay tuned for our last preprint before the end of the year... lots of FUCCI colors 🎄-style and metabolic enzymes on chromatin during cell cycle progression COMING SOON 💥

🚀 The NUCLEAR Project website is live! 🌟 Explore how metabolism regulates genome function & cell identity. 💡 Cutting-edge research, interdisciplinary training, & international collaboration. 🌍 Learn more: nuclear-dn.eu #MarieCurieActions #PhD

🚨 16 PhD positions open in early 2025! 🚀 Join NUCLEAR for cutting-edge research on nuclear metabolism, cell identity, and genome function. 🌍 Details on projects, eligibility & applications coming soon.Stay tuned! #PhDOpportunities#MarieCurieActions 👉http://nuclear-dn.eu

Looking for a PhD position? We have 16 available in our NUCLEAR Horizon MCSA Doctoral Network. Don't miss the opportunity! nuclear-dn.eu/2024/12/18/1...

We made it among the BEST PICTURES OF THE YEAR by @natureportfolio.bsky.social www.nature.com/immersive/d4... Beautiful image representing in red the nuclear localization of MTHFD2 in pluripotent colon organoids by @NataliaPardoL Find the manuscript here: www.nature.com/articles/s41...

Thanks to @bpodaily.bsky.social for choosing our beautiful colon organoid as a picture of the day. MTHFD2 in the nucleus in red: bpod.org.uk

Our amazing CRG PhD community are celebrating their annual symposium today and tomorrow. Follow our first year students on Bluesky for snippets about all the amazing talks featured this year: @lassemiddendorf.bsky.social @mattezambon.bsky.social @iseultleahy.bsky.social

hey everyone! i made a list of some useful starter packs (primarily biology/earth sciences with a few bonus things thrown in) to share with friends who have joined bsky in the last week and thought it may be useful for some people here too! 🌍🧪 #SciSky #BioSky docs.google.com/document/d/1...

Starter packs

BIOLOGY Ecology Macroecology https://go.bsky.app/GBn9pNZ Global ecology https://go.bsky.app/V6tN4cv Trait based ecology and evolution https://go.bsky.app/PThMXeX Invasion biology https://go.b...

docs.google.com

I have curated a second "metabolism" starter pack, as the first quickly got full. Please have a look, and I am happy to add others (sorry for those who may appear in both): go.bsky.app/CH1MctZ

Amazing opportunity to join a great group.

Arnau Sebé-Pedrós@arnausebe.bsky.social · 2y ago

We have two open PhD positions in my group at @crg.eu. We are seeking candidates with a background in computational and/or molecular biology, and with a broad interest in evolutionary biology, gene regulation, and comparative genomics. 📅Apply before January 12 here: www.crg.eu/en/content/t...

🧪Apply for your #ECR place at our Workshop on 'Mechanometabolism Unleashed: The Interface of Cell Mechanics and Metabolism', organised by Marco Foiani, Ana-Maria Lennon-Duménil, @vickysanzmoreno.bsky.social & Giorgio Scita 📆Apply by 13 Dec bit.ly/3OnLFvV #BiologistsWorkshops

Both #Cancer #Research starter packs are now completely full! ~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️ I hope you'll find these useful to build our community here Pack 1: go.bsky.app/FEoaJMc Pack 2: go.bsky.app/6EcjWNA

This month we published 2 MANUSCRIPTS in @natureportfolio.bsky.social , nature communication 1. Natalia Pardo discovers the role of nuclear MTHFD2 in centromere stability 2. Espinar and Garcia-Cao reveal the role of nuclear IMPDH2 in the DNA damage response. Nuclear Metabolism is on 🔥