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Sean Bresnahan

@seantbres.bsky.social

Associate Data Scientist at MD Anderson Cancer Center. Fetal programming, functional genomics, molecular epidemiology, & causal inference. Opinions are my own. https://seantbresnahan.com https://bhattacharya-lab.com

188 Posts625 Follower658 Folgt
Nicholas Mancuso @nmancuso.bsky.social · 4mo ago

Thrilled to see this out. What started out as a chat several years back with @drfejzo.bsky.social about leveraging publicly available data on hyperemesis gravidarum GWAS turned into a wonderful collaboration with April Shu, @mvaudel.bsky.social, @xwww.bsky.social and many others! rdcu.be/fdl9k

Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting

Nature Genetics - Multi-ancestry GWAS meta-analysis identifies risk loci for severe nausea and vomiting of pregnancy. Downstream analyses explore maternal and fetal contributions of these loci and...

rdcu.be

Ida Momennejad@neuroai.bsky.social · 4mo ago

Some reports say over 500 schools, 55 libraries, & 25 universities hit. You can debate the numbers, but hitting Sharif University & Beheshti is like hitting MIT & Stanford. I keep wondering: How would the scientific community respond differently if it was those universities? What’s the difference?

Arjun Bhattacharya@arjunbhattac.bsky.social · 4mo ago

Another preprint from our group @mdanderson.bsky.social led by talented postdoc @seantbres.bsky.social! Joint with @jonhuang.bsky.social, exploring the intersection of environmental toxins, maternal/fetal health, and placental txomics. Tweet thread below!

Sean Bresnahan@seantbres.bsky.social · 4mo ago

🧬Another new preprint with @jonhuang.bsky.social @uhmanoa.bsky.social & @arjunbhattac.bsky.social @mdanderson.bsky.social ! We used variation in how PFAS cross the placenta to dissect the transcriptional architecture of effects on birthweight & gestational age🧵 www.biorxiv.org/content/10.6...

Transplacental transfer efficiency reveals dose-dependent network architectures linking PFAS exposure to birth outcomes. Per- and polyfluoroalkyl substances (PFAS) exhibit varied transplacental transfer efficiencies (TPTE), quantified as the ratio of fetal cord blood to maternal blood concentrations. PFOS shows low TPTE with limited fetal exposure, while PFBS demonstrates high TPTE with substantial transfer to the fetus. PFAS concentrations were measured in maternal blood and fetal cord blood alongside placental transcriptomics, gestational age at delivery, and birth weight. Placental transcripts mediating PFAS effects on birth weight were characterized by four network properties: mediator count (number of significant mediating transcripts), co-expression strength (|kME|, representing correlation with module eigengene and shown as network connectivity), network centrality (hub positioning within the network), and compartmentalization (spatial clustering of maternal versus fetal mediators). Birth weight exhibited coordinated TPTE-dependent responses across these network metrics, with high-TPTE compounds engaging more numerous, strongly co-expressed mediators occupying central network positions with distinct maternal-fetal compartmentalization. In contrast, gestational age showed minimal coordinated network reorganization in response to TPTE variation, indicating distinct molecular architectures underlying PFAS effects on these different outcomes.
Kevin Bird@stairwaytokevin.bsky.social · 4mo ago

A lot of very good food for thought here of where population and quantitative/statistical genetics have room for improvement in thinking about, performing, and communicating their research

Ian Myles, MD/MPH@lcdriammdmph.bsky.social · 4mo ago

Excited to share a recent publication co-authored with Dr Chris Donohue, former historian of genetics/eugenics at the National Human Genome Research Institute. It's an overview of how modern population genetics contributes to its own weaponization. onlinelibrary.wiley.com/doi/epdf/10....

Chris Murphy@chrismurphyct.bsky.social · 5mo ago

It’s crystal clear now that Trump has lost control of this war. He badly misjudged Iran’s ability to retaliate. The region is on fire. 1/ I’m going to explain to you in this🧵what I’ve learned - in part from closed door briefings - about the four biggest current crises.

ProPublica@propublica.org · 6mo ago

1/ ProPublica collected handwritten letters in mid-January from children held at the Dilley Immigration Processing Center, the same facility where 5-year-old Liam Conejo Ramos was taken. Hundreds of kids are still detained. We’ll let the children’s words speak for themselves. 🧵

Mark Histed@markhisted.org · 6mo ago

This. Science and democracy are linked. We can’t put science advocacy in a bubble and do it alone— the fascism, division, and attack on experts and trust are *the reason* science is under attack. Plus the inside advocacy alone does not work! Just look at what happened with MYF this year.

Colette Delawalla, PhD@cdelawalla.bsky.social · 6mo ago

MERE HOURS after the President of the United States posted an AI video of the Obama’s as monkeys, the Science Tech Action Committee (led by @aaas.org and @researchamerica.bsky.social) posted a THANK YOU to TRUMP for SIGNING THE BUDGET. Shot. Chaser. sciencetechaction.org/aboutus/

STAC Statement Thanking President Donald Trump for Signing the Senate Amendment to H.R. 7148, the Consolidated Appropriations Act
Colette Delawalla, PhD@cdelawalla.bsky.social · 6mo ago

If you have the privilege of living in a democracy, it is your civic duty to protect democracy when it’s in peril. If you have the privilege of being a scientist, you have the civic duty of protecting science. So yeah, scientists in America: ITS TIME TO BE YELLIN.

Colette Delawalla, PhD@cdelawalla.bsky.social · 6mo ago

Someone on LinkedIn just asked me "why scientists should care and mobilize" right now. But the answer is simple: BECAUSE IT IS THE MORALLY RIGHT THING TO DO. People are being killed in the street, our democracy is being eroded, & we are watching the onset of authoritarianism before our eyes. 1/

Sean Bresnahan@seantbres.bsky.social · 6mo ago

Tulsa stands with you, Minneapolis. More than 100 people showed up to a vigil Tuesday evening at LaFortune Park in Tulsa, OK to remember people murdered by federal officers of the Trump regime. Photos by Mike Simmons, Tulsa World.

Vigil participants stand with signs and flags. Photos by Mike Simmons, Tulsa World.Man in orange beanie and brown jacket lights Taper candles planted into a snow bank.Vigil participants kneel beside the makeshift vigil.A closeup of the vigil: candles planted into the snowbank, with flowers and notes strung about.
Nicole Bedera@nbedera.bsky.social · 7mo ago

I’m seeing posts from people (outside of MN) about how US citizens should carry their passports. And let me say that *inside* MN, we are calmly responding to requests with: “No, I don’t have to show you any documentation.” Because that’s how you protect everyone, regardless of immigration status.