#TWiNPP From Baldi et al., baseline network alignment may be a useful biomarker for optimizing TMS outcomes in depression and anxiety / @shansiddiqi.bsky.social www.nature.com/articles/s41...

Target engagement in a head-to-head clinical trial of dysphoric versus anxiosomatic transcranial magnetic stimulation targets - Neuropsychopharmacology

Neuropsychopharmacology - Target engagement in a head-to-head clinical trial of dysphoric versus anxiosomatic transcranial magnetic stimulation targets

nature.com

I always assumed that brain function had to line up with cytoarchitectonics. It turns out I was wrong. Human cortex, especially PFC, is tiled by chains of functional patches that subdivide and interlink architectonic areas into parallel processing streams. www.biorxiv.org/content/10.6...

We often treat functional connectivity as if it’s an established measure of TMS target engagement. I’m not so sure. Check out our new paper by Samantha Baldi in @npp-journal.bsky.social on rsfMRI data from a head-to-head TMS trial. free link: rdcu.be/feIya full link: lnkd.in/eSdthbSg

Target engagement in a head-to-head clinical trial of dysphoric versus anxiosomatic transcranial magnetic stimulation targets

Neuropsychopharmacology - Target engagement in a head-to-head clinical trial of dysphoric versus anxiosomatic transcranial magnetic stimulation targets

rdcu.be

A wave of new papers discuss the merits and limitations of lesion network mapping. #neuroskyence By @avaskham.bsky.social www.thetransmitter.org/brain-imagin...

‘Overdue’ debate unfurls over neuroimaging method

After a January paper questioned the validity of an approach called lesion network mapping, its users are pressure testing their results.

thetransmitter.org

New paper in Molecular Psychiatry: In patients with anxiety + depression, targeting a novel “anxiosomatic” circuit (dmPFC) outperforms standard dlPFC for anxiety—and is equally effective for depression. Free link: rdcu.be/faL22 Full link: lnkd.in/e4WZTncu But the bigger story is the pipeline 1/n

BraSSS starts today at 9am ET! ZOOM: mgb-org.zoom.us/j/86743220335 Passcode: 362150 Agenda here: www.eventbrite.com/e/brain-stim...

Brain Stimulation Subspecialty Summit (BraSSS)

Third Annual Meeting of the Brain Stimulation Society, focused on formal recognition of brain stimulation as a clinical subspecialty

eventbrite.com

A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method. See below 👇 for our response. www.biorxiv.org/content/10.6...

Michael Fox@foxmdphd.bsky.social · 6mo ago

A recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...

The methodological foundations of lesion network mapping remain sound https://www.biorxiv.org/content/10.64898/2026.02.24.707529v1

A recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...

When we use TMS to treat depression, we think it alters neural activity in a deep brain structure known as the subgenual anterior cingulate (sgACC). But this is hard to test directly, until our preprint with @coreykeller.bsky.social, @neuro-engineer.bsky.social, Nick Trapp, and Aaron Boes (UIowa) 1/

DLPFC Stimulation Suppresses High-Frequency Neural Activity in the Human sgACC

Transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (DLPFC) is hypothesized to relieve symptoms of depression by inhibiting activity in the subgenual anterior cingulate corte...

biorxiv.org

Is generalized epilepsy a seizure of the whole brain or a specific brain network? In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome. Paper: nature.com/articles/s41... A 🧵 below:

A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications

Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...

nature.com

Out now in Brain A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican. With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman academic.oup.com/brain/advanc... @braincircuits.bsky.social

Looking toward to our ANPA symposium on interventional neuropsychiatry - kicked off w a brilliant talk & overview on TMS by Nick Trapp.

I think the theoretical limit of explainable variance in a model should be less than the product of the test-retest reliabilities of the input variables. If the explained variance in a study exceeds that value (as it often does in the psychiatric literature), the model must be overfit.

Out now in Brain Stimulation Towards accredited training in brain stimulation: proceedings from the Brain Stimulation Subspecialty Summits (BraSSS) with co-host Nolan Williams and 23 other awesome co-authors including some from @braincircuits.bsky.social www.brainstimjrnl.com/article/S193...

Finally … this also means I am recruiting – big time! Please email me in case you know somebody that might be interested (PhD/Postdoc positions). Please RT for reach! 🙏🙏

a yellow sign that says we 're hiring

ALT: a yellow sign that says we 're hiring

media.tenor.com

My cat has developed a penchant for ⁦‪Kraepelin‬⁩. Last couple of days she just sits next to this old book (first edition English translation) and tries to read it.

jamanetwork.com/journals/jam... Thread below👇

Mapping Lesions That Cause Psychosis

This case-control study analyzes published cases of lesion-induced psychosisTo assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit

jamanetwork.com

Can damage to a specific brain circuit cause psychosis? New paper out today by @andrewpines.bsky.social @shansiddiqi.bsky.social says Yes! Hub of the circuit is in the hippocampus - great alignment with NMDA encephalitis. @braincircuits.bsky.social

Andrew Pines@andrewpines.bsky.social · last yr.

What brain regions are involved in causing psychotic symptoms? Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients! 1/n🧵

Do lesions that cause psychosis fall into a common brain network? Exciting new work by @andrewpines.bsky.social, @shansiddiqi.bsky.social and colleagues – tweetorial below by the first author, paper here: jamanetwork.com/journals/jam...

Mapping Lesions That Cause Psychosis

This case-control study analyzes published cases of lesion-induced psychosisTo assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit

jamanetwork.com

Andrew Pines@andrewpines.bsky.social · last yr.

What brain regions are involved in causing psychotic symptoms? Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients! 1/n🧵

What brain regions are involved in causing psychotic symptoms? Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients! 1/n🧵

When the Nazis took power, I've of their most effective actions was to destroy the universities.

Carl T. Bergstrom@carlbergstrom.com · 2y ago

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...

Super cool to finally meet @shansiddiqi.bsky.social this morning and hear about his lesion network mapping data for schizophrenia - and their consilience with our computational work in primates and paranoia! #MDThalamus

Phil Corlett@philcorlett.bsky.social · 2y ago

Early start (7:30am symposium) in Grand Ballroom C, for WinterBrain ❄️🧠 I’ll be talking about translational approaches to paranoia, and consilience across rodents, primates, and humans

I get it, bsky is great, but I find it harder to get motivated when there’s no vitriol to fight. I need a troll.

Anybody have experience with a successful R33 application? There's no budget limit, so I'm trying to figure out what kind of budget might be perceived as excessive.

ECT, TMS, and ketamine outperform other options for treatment resistant depression. Should we be offering these options to patients earlier in the course of illness? www.nature.com/articles/s41...

Relative effectiveness of antidepressant treatments in treatment-resistant depression: a systematic review and network meta-analysis of randomized controlled trials - Neuropsychopharmacology

Neuropsychopharmacology - Relative effectiveness of antidepressant treatments in treatment-resistant depression: a systematic review and network meta-analysis of randomized controlled trials

nature.com

We are launching a new Harvard Medical School Continuing Medical Education Course Brain Medicine: Integrating the Clinical Neurosciences Live Virtual Course w On Demand Viewing for 30 days February 7th, 2025 Registration Details Below (Join Us!): cmecatalog.hms.harvard.edu/brain-medici...

🚨Interested in Dystonia?🚨 @braincircuits.bsky.social GPi DBS for dystonia is effective. More recently, STN DBS has been investigated, as an alternative. In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks… www.pnas.org/doi/10.1073/...

New use for ChatGPT: help me figure out how to respond to this reviewer comment without throwing off the overall flow of the paper.

Happy to share Bryan Jenkins' latest work published in @psychopharmacology.bsky.social: Cannabidiol potentiates physiological and behavioral markers of hypothalamic–pituitary–adrenal (HPA) axis responsivity in female and male mice link.springer.com/article/10.1.... Bryan truly led this project!

Cannabidiol (CBD) potentiates physiological and behavioral markers of hypothalamic–pituitary–adrenal (HPA) axis responsivity in female and male mice - Psychopharmacology

Rationale Clinical literature indicates there may be a therapeutic use of cannabidiol (CBD) for stress-related disorders. Preclinical literature remains conflicted regarding the underlying neurobehavi...

link.springer.com