SO PROUD of my amazing students representing team ACORN Lab @acornlab.bsky.social at #SOBP2026! I am the luckiest mentor! 🥰 Way to go Natalie, @caitiebaten.bsky.social and @heatherarobinson.bsky.social! 🎉

Arielle Keller@ariellekeller.bsky.social · 3mo ago

Come see the latest from ACORN Lab at #SOBP2026! 🐿️🧠🗽 Thread below! 👇

Thank you @avaskham.bsky.social @thetransmitter.bsky.social for covering the ongoing discussion re lesion network mapping. It is commendable when a news publication covers both sides of an issue, and a great example of unbiased and responsible reporting.

The Transmitter @thetransmitter.bsky.social · 4mo ago

A wave of new papers discuss the merits and limitations of lesion network mapping. #neuroskyence By @avaskham.bsky.social www.thetransmitter.org/brain-imagin...

Our work on how neural circuits in the cerebellum encode prior probabilities led by Julius Koppen is out now in Nature Neuroscience www.nature.com/articles/s41... Big thanks to Julius Koppen & the whole team! And dedicated to all of us who found inspiration in Bayesian theories of the brain!

Neural circuits encode prior knowledge of temporal statistics - Nature Neuroscience

This study shows that cerebellar circuits learn and encode prior probabilities of event timing. Cell-type-specific neural activity reflects environmental statistics and guides predictive motor behavio...

nature.com

Have you heard about the primacy of movement over sensation? Why is action the ultimate source of knowledge? Check it out in our brand new episode with none less than György Buzsáki here: stimulatingbrains.org/76-gyorgy-bu...

Andreas Horn breaks down recent exchanges on the lesion network mapping method.

Andreas Horn@andreashorn.org · 5mo ago

A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method. See below 👇 for our response. www.biorxiv.org/content/10.6...

This is a robust response. I particularly liked this figure - clarifying why the original critique showed what it did, and what was missing @foxmdphd.bsky.social

Phil Corlett@philcorlett.bsky.social · 5mo ago

The lesion-network mappers reply 🍿

We don't think it invalidates the approach. We looked into this in our data and replicated the key result showing convergence to non-specific connectome structure. However, our results also suggest there is a practical fix that is already implemented in some LNM studies. bsky.app/profile/pete...

Marvin Petersen@petersenm.bsky.social · 5mo ago

New preprint: Revisiting the methodological foundation of lesion network mapping. doi.org/10.64898/202... A thread.

New preprint: Revisiting the methodological foundation of lesion network mapping. doi.org/10.64898/202... A thread.

Revisiting the methodological foundation of lesion network mapping

Lesion network mapping (LNM) links focal brain lesions to distributed neural circuits by projecting lesion locations through a normative functional connectome. van den Heuvel and colleagues recently s...

doi.org

A recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...

A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method. See below 👇 for our response. www.biorxiv.org/content/10.6...

Michael Fox@foxmdphd.bsky.social · 5mo ago

A recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...

🧠⚡ New year, fresh StimBrains talks! Join us when we explore the brain networks driving schizophrenia & how we can treat them via DBS. January session (Thurs, Jan 29, noon ET / 6pm CET) feat. the amazing @andrewpines.bsky.social & Nicola Cascella ✨ Get Zoom link here: talks.stimulatingbrains.org

What is the status of DBS for epilepsy? Find out in our new review/metaanalysis spearheaded by @laurenahart.bsky.social & Garance Meyer in JNNP: pubmed.ncbi.nlm.nih.gov/40666371/ A 🧵 — please RT for reach! 🙏

Super excited about this!

Stimulating Brains@stimulatingbrains.org · 7mo ago

🧠⚡ New year, fresh StimBrains talks! Join us when we explore the brain networks driving schizophrenia & how we can treat them via DBS. January session (Thurs, Jan 29, noon ET / 6pm CET) feat. the amazing @andrewpines.bsky.social & Nicola Cascella ✨ Get Zoom link here: talks.stimulatingbrains.org

Activating brain regions linked to reward and positive expectations may be associated with increased antibody responses following vaccination, suggesting a connection between mental states and immune function. doi.org/hbkjfq

Can training your brain boost immune response? Vaccination study highlights power of positive thinking

Training people to activate a part of the brain linked to reward and positive expectations may be associated with an increase in the body's immune response to a vaccine.

medicalxpress.com

Are connectome-based network mapping methods and the >200 papers that have used it invalid? New paper out in @NatureNeuro says YES. nature.com/articles/s41... I have concerns about this new paper's methods and conclusions, but am biased. What do others think?

Investigating the methodological foundation of lesion network mapping - Nature Neuroscience

The lesion network mapping method links diverse brain lesions to similar functional brain networks, reflecting general brain organization rather than disorder-specific circuits.

nature.com

New Perspective from myself, Sarah Heilbronner and @myoo.bsky.social . “Rethinking the centrality of brain areas in understanding functional organization” in Nature Neuroscience. 🧵 rdcu.be/eVZ1A

Rethinking the centrality of brain areas in understanding functional organization

Nature Neuroscience - Parcellation of the cortex into functionally modular brain areas is foundational to neuroscience. Here, Hayden, Heilbronner and Yoo question the central status of brain areas...

rdcu.be

The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more! Please rt and reach out if you’re interested 👀 Find out more holmeslab.rutgers.edu

🚨 New preprint out! 🚨 “Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application” 🔗 doi.org/10.1101/2025...  🧵 A short thread:

1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements... doi.org/10.1038/s415...

Alert!!!! “An Action Networks Model for Pain” We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it. 👉 thread below 🧵 osf.io/preprints/ps...

Thrilled our ADHD network mapping work is now out in Annals of the Child Neurology Society, and honored to be featured on the cover! 🔗 Full article: onlinelibrary.wiley.com/doi/full/10.... @childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social

Coordinate Network Mapping of Focal Brain Volume Differences in ADHD Reveals Common Patterns That Lack Specificity: A Systematic Review

Objective Attention-deficit/hyperactivity disorder (ADHD) has been associated with decreased regional brain volume, yet no consistent localization has emerged across studies. This discrepancy has be...

onlinelibrary.wiley.com

Out now in Brain A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican. With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman academic.oup.com/brain/advanc... @braincircuits.bsky.social

Mixed Bag #22: Nils Wendel on Learning Psychopharmacology Wendel explores the topic using a book, a concept, a person, an article, and a surprise item www.psychiatrymargins.com/p/mixed-bag-...

Mixed Bag #22: Nils Wendel on Learning Psychopharmacology

A book, a concept, a person, an article, and a surprise item

psychiatrymargins.com

MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects? @science.org @braincircuits.bsky.social @netstim.org – a thread🧵! www.science.org/doi/10.1126/...

The brainstem’s red nucleus is an evolutionarily old structure that emerged as animals began to use limbs for walking, but its function in humans reaches beyond motor control, a new study suggests. By @sydneywyatt.bsky.social #neuroskyence www.thetransmitter.org/brain-imagin...

‘Old’ brainstem structure evolved beyond basic motor control

The human red nucleus may also help coordinate action, reward and motivated behavior, a new study suggests.

thetransmitter.org

When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal: doi.org/10.1016/j.br...

🧠💊New preprint differentiating antipsychotic medication vs. illness effects on cortical thickness in people w/ psychosis. Finding: People receiving placebo show prominent cortical thinning over 1st year of illness, whereas those receiving antipsychotics do not. 1/3 www.medrxiv.org/content/10.1...

We’re hiring a clinical research coordinator to lead a neuroimaging study on brain changes across pregnancy and perinatal depression. wd1.myworkdaysite.com/en-US/recrui... Please RT.

It was a great honor to talk with the founding editor of Brain Stimulation, Dr. Harold Sackeim! Beyond the past, present and future of ECT, we covered the entire field of neuromodulation. Priceless insights from a key leader in the field! Tune in here 👇 stimulatingbrains.org/71-harold-sa...

We had a truly inspiring and insightful conversation with Dr. Rees Cosgrove, Director of Epilepsy and Functional Neurosurgery at @brighamandwomens.bsky.social & Professor of Neurosurgery @harvardmed.bsky.social Rediscovering the lost art of brain lesions…! stimulatingbrains.org/70-rees-cosg...