RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...

Analog intrinsic recoding measures RNA dynamics without chemical conversion

Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...

biorxiv.org

I am delighted to share that I have been awarded a Walter Benjamin Postdoctoral Fellowship from the @dfg.de to support my work in @grothlab.bsky.social at the Danish Cancer Institute. #DFG #cancerresearch #epigenetics

Here is our article published in Nature Comm, on new players in chromatin dynamics after UV repair. This work highlights the histone chaperones DNAJC9 and MCM2 as central players in chromatin repair. Our proteomic dataset opens up new perspectives for dissecting epigenome maintenance mechanisms.

Proteomic profiling of UV damage repair patches uncovers histone chaperones with central functions in chromatin repair - Nature Communications

Chromatin states need to be maintained during DNA damage repair. Here, the authors expand the histone chaperone network involved in repair-coupled chromatin restoration and highlight a mechanistic coo...

nature.com

Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex...

Small contribution to the eternal match happening inside every cell: in the red corner, replication. In the blue corner, transcription. Both convinced they own the genome. Another amazing collaboration with @hamperllab.bsky.social and @luijsterburglab.bsky.social lnkd.in/ey9tH7YF

Excited to share a new preprint from the lab by @melissamcevoy.bsky.social The S/G2 checkpoint prevents the premature shutdown of the DNA replication program. Without it, cells fail to finish replicating their chromosomes and have severe mitotic errors. www.biorxiv.org/content/10.6...

We are looking for a PhD student to study chromatin changes related to heart regeneration, in collaboration with @bakkerslab.bsky.social . Please share and apply! www.hubrecht.eu/nl/vacature/...

Our new paper is finally out! 📢 Great team effort from Sara M, @joanasgrmrtnz.bsky.social and @agalleg.bsky.social with the support from everyone in the lab. Many thanks to our collaborators, @andreichabes.bsky.social , @mmaslon.bsky.social and @lschermelleh.bsky.social

Slow RNAPII elongation enhances naive pluripotency rewiring while maintaining high replication fork speed

Slowing RNAPII velocity boosts naive pluripotency, uncovering an unexpected link to cell plasticity.

science.org

We go live!!! Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field AND !! registration is FREE 🥳 (but mandatory) - we hope to see many in Munich 🍺 @helmholtzmunich.bsky.social @replifate.bsky.social @epicrossborders.bsky.social replifate.eu/event/meetin...

Events for February 2026

06-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...

replifate.eu

Glad to have been part of this great story and a fun collaboration between @saldivar-lab.bsky.social and @hamperllab.bsky.social! We discover an exciting new function of ATR in dissolving transcriptional condensates at the HLB to fine-tune linker histone expression and prevent genome instability.

Joshua Saldivar@saldivar-lab.bsky.social · 6mo ago

I am excited to share the first paper from the Saldivar lab! A special thank you to all who contributed. Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability: Molecular Cell www.cell.com/molecular-ce...

Dear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt

PAF15–PCNA exhaustion governs the strand-specific control of DNA replication

Nature - PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.

rdcu.be

Excited to share our new Nature study! 🧬 We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability. Full paper: www.nature.com/articles/s41...

𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n

Repair of DNA double-strand breaks leaves heritable impairment to genome function

Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...

tinyurl.com

Histone acetylation - not always about transcriptional activation: H4K16ac safeguards the genome replication program by repressing premature replication of heterochromatin. Well done Marta Milan! tinyurl.com/yuy9m8t3

We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute! Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉

PhDone! Last week, an incredible journey of 4.5 years came to an end when I defended my PhD at the LMU in Munich. I am tremendously grateful for all the fun moments throughout this chapter, full of learning and doing cool science.

Great work from @ioannistsirkas.bsky.social and the @hamperllab.bsky.social!

Hamperl Lab@hamperllab.bsky.social · last yr.

Our latest research is online in the @biorxivpreprint.bsky.social! 🧬🎉 🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression. www.biorxiv.org/cgi/content/...

Great overview on some of the recent work from my PhD lab! @hamperllab.bsky.social

European Research Council (ERC)@erc.europa.eu · last yr.

🔬 Stephan Hamperl ‪uncovered how clashes between #gene reading & #DNA copying inside cells drive disease. Their tools reveal new insights into #cancer, ageing & development. Read more 👉 europa.eu/!H7RtjQ #FrontierResearch #GeneEditing #Genetics #Oncology @www.helmholtz-munich.de

Linker histone expression is uniquely controlled by a specific pathway, which can be manipulated to increase TOP2i sensitivity! Proud to share first authorship on our story now out in @cp-molcell.bsky.social. www.cell.com/molecular-ce...

CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance

Ingham et al. identify a dedicated H1 linker histone biogenesis pathway in human cells, driven by the protein CRAMP1 that functions as an H1 transcription factor. They demonstrate that defective CRAMP...

cell.com

Are you @ the late stages of your postdoc ? Want to pursue a PI career ? Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum www.helmholtz-munich.de/en/stem-cell... Peer-networking / Career orientation and more !!! Please distribute :) 🙂

Epigenetics at Helmholtz Munich@epihmgu.bsky.social · last yr.

🎤 Postdocs: want to take the next step and become a #PI? Apply to speak at the TALENT FORUM @www.helmholtz-munich.de, showcase your research in Epigenetics & Nucleic Acids, and connect with top scientists. 🧳 Travel & accommodation covered if selected! 📝 Apply by 31July. 🔗 Info: lnkd.in/drkRvz7N

Delighted to share that the results of my main postdoc project are now published in @nature.com 🔗 doi.org/10.1038/s415...

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature

A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

doi.org

🚨 Postdoc wanted (🇳🇱NL based) for our exciting collaboration with the lab of Alexander van Oudenaarden @hubrechtinstitute.bsky.social in Utrecht, with collaborative visits to our lab Copenhagen 🇩🇰. We seek a computational scientist to model epigenetic inheritance, see more below 👇!

Jeroen van den Berg@jervdberg.bsky.social · last yr.

🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰). Come work in our collaberative team of top scientists shorturl.at/avBBy

🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰). Come work in our collaberative team of top scientists shorturl.at/avBBy

Delighted to share that I am joining @grothlab.bsky.social and @groth-anja.bsky.social at Danish Cancer Institute for my postdoc. 🇩🇰 I am looking forward to working on advancing our understanding of epigenome replication and maintenance. 🧬🧫

Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:

🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome

🌟 SAVE THE DATE: Talent Forum 2025! 🗓️ November 18–19 📍 @www.helmholtz-munich.de‬, Germany Showcase your research and network with global talents in #Epigenetics & Nucleic Acids Research! Apply by July 31 for a speaker spot —travel & accommodation covered. 🔜 Website coming soon!

Goodbye @hamperllab.bsky.social and thank you for incredible 4.5 years! It has been a pleasure to work with all of you and I will miss you a lot. Thank you also to @epihmgu.bsky.social and the Munich chromatin community. I could not have picked a better place to do my PhD! To new adventures! 🇩🇰

A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.

The Groth lab@grothlab.bsky.social · last yr.

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

Two days of science, international cooking, and breathtaking hikes in the Bavarian Alps—our lab retreat in Mittenwald had it all! Great discussions, great food, and even better company.