Transplantation of human #iPSC -derived #microglia ameliorates #neuropathology and circuit dysfunction in #progranulin -deficient mice Hayk Davtyan, Sarah Naguib, Yuliya Voskobiynyk... Jeanne T. Paz, Mathew Blurton-Jones, Li Gan @liganlab.bsky.social link.springer.com/article/10.1...

A beautiful review by @lukensjohnr.bsky.social lab on microglial ITAM and ITIM: Microglial ITAM & ITIM signaling in neurodegenerative disease and brain aging. www.sciencedirect.com/science/arti...

Microglial ITAM & ITIM signaling in neurodegenerative disease and brain aging

Innate immunity within the central nervous system (CNS) plays key roles in shaping both healthy brain aging and vulnerability to neurodegenerative dis…

sciencedirect.com

Proud to announce our collaboration with @blurtonjoneslab.bsky.social & the Paz lab showing that transplanted human iPSC-derived microglia in a PGRN KO mouse model restores progranulin in microglia and rescues pathology, circuitry, and behavior. Preprint out now: www.biorxiv.org/cgi/content/...

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice

Frontotemporal dementia (FTD) is a major cause of early-onset neurodegeneration characterized by progressive behavioral, emotional, and cognitive decline. Progranulin haploinsufficiency, a leading gen...

biorxiv.org

Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer’s disease | Science Translational Medicine www.science.org/doi/10.1126/...

Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer’s disease

PILRA is a therapeutic target for Alzheimer’s disease that regulates neuroinflammation and metabolism in microglia.

science.org

Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social

Really excited to share this work from @blurtonjoneslab.bsky.social lab, “Human microglia differentially respond to β‐amyloid, tau, and combined Alzheimer's disease pathologies in vivo” - Coburn - Eskandari-Sedighi, 2025 - Alzheimer's & Dementia alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

new preprint from @iostephens.bsky.social describes the potential benefits of increasing lipid turnover in microglia by eliminating PLIN2 from their surface

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 11mo ago

Knockout of Perilipin 2 in Microglia Alters Lipid Droplet Accumulation and Response to Alzheimer's Disease Stimuli https://www.biorxiv.org/content/10.1101/2025.09.02.673815v1

Thanks for putting together such a fantastic meeting, and for the opportunity to present! It was great to be part of the conversation with the rest of speakers.

International Society for Molecular Neurodegeneration@ismnd.bsky.social · 12mo ago

👏 Great start to NextGen 2025! S1: Cellular Immune Responses in the Pathogenesis of #AlzheimersDisease Hosts: Kristine Freude & Marion Kadlecová Speakers 🔹 Ghazaleh Eskandari-Sedighi 🔹 Lukas Busch 🔹 Johannes Schlachetzki 🔹 Zhiyuan Ning 🔹 Guoyan Zhao

👏 Great start to NextGen 2025! S1: Cellular Immune Responses in the Pathogenesis of #AlzheimersDisease Hosts: Kristine Freude & Marion Kadlecová Speakers 🔹 Ghazaleh Eskandari-Sedighi 🔹 Lukas Busch 🔹 Johannes Schlachetzki 🔹 Zhiyuan Ning 🔹 Guoyan Zhao

Are you an ATP!?! We are hosting our 2nd annual CNS MET Symposium 12/3/25 and are searching for early-career researchers to highlight as All-star Trainee Presentations (ATPs). Up to 4 individuals will be invited for an all-expense paid trip to beautiful Lexington KY. Apply here! rb.gy/3zk4cm

Identification of CD33m as a new protective factor in Alzheimer’s Disease development. Read about this research by Brain Star Award winner Ghazaleh Eskandari-Sedighi can-acn.org/brain-star-a... @ualberta.bsky.social @ghazeskandari.bsky.social

Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...

Post-Translational Modifications Remodel Proteome-Wide Ligandability

Post-translational modifications (PTMs) vastly expand the diversity of human proteome, dynamically reshaping protein activity, interactions, and localization in response to environmental, pharmacologi...

biorxiv.org

Join us for the next GTA webinar on Siglecs and their glycan ligands, featuring Dr. @siglecdude.bsky.social (U of A) and Dr. Edward Schmidt. Learn how their team is developing novel tools to uncover the biological roles of Siglecs across systems. Register: canadianglycomics.ca/training/web...

So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in @cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!

Gan Lab@liganlab.bsky.social · last yr.

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

For #fluorescencefriday the Mesoscopic Integrated NeuroImaging Data (MIND) platform @westernu.bsky.social presents abeta plaques and blood vessels in the 🧠 of our ApoE4 mouse model of AD. 🧪 #clearing #lightsheet 🔬 Courtesy of Arash Salahinejad, Luke Smolders and @shahrzadbahrampour.bsky.social

On-demand microglia deliver the therapeutic payload in Alzheimer’s disease @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...

On-demand microglia deliver the therapeutic payload in Alzheimer’s disease

In this issue, Chadarevian et al. showed that engraftment of human iPSC-derived microglia (iMG) engineered to express secreted neprilysin (sNEP) under the plaque-responsive CD9 promoter reduces amyloi...

cell.com

Just out, recent work from the Plemel lab by the talented Brady Hammond. We sought to understand the factors that regulate microglial proliferation during development. journals.biologists.com/dev/article/...

CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation

Summary: In vitro and in vivo investigations indicate that CSF1 and IL34 may partially regulate the developmental proliferation of microglia in the mouse hippocampus and cortex, but an additional laye...

journals.biologists.com

What does the APOE 'lipid droplet-ome' look like??? Check out our new paper to find out! www.sciencedirect.com/science/arti... Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social +help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs

APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses

Excess lipid droplet (LD) accumulation is implicated in various diseases, including Alzheimer's disease (AD), yet the mechanisms underlying this accum…

sciencedirect.com

The registration for the second round of 2025 Canadian Neuroscience Series are open now. This was a fantastic opportunity for me to learn about the impressive work of other #postdocs and share mine with them. Highly recommend it to anyone eligible in the field of #Neuroscience.

Canadian Neuroscience Seminars – Postdoctoral Series (CNS-PDS)@cns-pds.bsky.social · last yr.

🇨🇦 🧠 Are you a #Postdoc in #Canada or #Canadian abroad? We are selecting #speakers for the (second round of the) 2025 Canadian #Neuroscience #Seminars: Postdoctoral Series. Apply by July 6th, 2025 @ 23:59PT. Find more details here: tinyurl.com/56m946jh Apply through this form: tinyurl.com/42cwhae3

🇨🇦 🧠 Are you a #Postdoc in #Canada or #Canadian abroad? We are selecting #speakers for the (second round of the) 2025 Canadian #Neuroscience #Seminars: Postdoctoral Series. Apply by July 6th, 2025 @ 23:59PT. Find more details here: tinyurl.com/56m946jh Apply through this form: tinyurl.com/42cwhae3

Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...

Inflammasome signaling in astrocytes modulates hippocampal plasticity

The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...

cell.com

Thanks to @canacn.bsky.social and #CIHR for choosing my work on human CD33 isoforms in Alzheimer’s disease for a #brainstar_award. I share the credit with Matt Macauley lab @siglecdude.bsky.social and all the amazing co-authors whose tremendous help was a huge contribution to this project.

Canadian Association for Neuroscience@canacn.bsky.social · last yr.

Very proud to announce the winners of the 2024 Brain Star Awards! can-acn.org/congratulati... Très fiers d'annoncer les gagnants des prix Cerveau en tête 2024! can-acn.org/fr/bravo-aux...

Very proud to announce the winners of the 2024 Brain Star Awards! can-acn.org/congratulati... Très fiers d'annoncer les gagnants des prix Cerveau en tête 2024! can-acn.org/fr/bravo-aux...

Meet our first speaker 🗣️ Ghazaleh will be presenting at our webinar THIS Thursday! You can register here: zoom.us/webinar/regi... And remember, you can stay up to date on webinars, events, and more by subscribing to our mailing list: t.co/Oa9dLowy1h

Happening THIS week! Register here: zoom.us/webinar/regi... Stay up to date by subscribing to our mailing list: t.co/Oa9dLowy1h

The Alzforum note on the newest publication from Blurton-Jones lab: "Delivery Courier? Microglia Drop Neprilysin Off Near Plaques in Brain" www.alzforum.org/news/researc...

We are back next Thursday (May 1st) with two wonderful presentations 📅 Register now: zoom.us/webinar/regi... And remember, you can stay up to date on webinars, events, and more by subscribing to our mailing list: t.co/Oa9dLowy1h

Exciting work from @blurtonjoneslab.bsky.social + Spitale labs -- new examples of how iPSC-microglia can be used as a long-term, in vivo platform for a therapeutic protein payload in models of Alzheimer’s disease @cp-cellstemcell.bsky.social sciencedirect.com/science/article/pii/S1934590925000992

Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins

Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…

sciencedirect.com

Nice media coverage of our recent study on how Tim-3 regulates microglial activity. #ButovskyLab @genelayinstitute.bsky.social. Researchers @massgenbrigham.bsky.social @harvardmed.bsky.social gaining ground on Alzheimer’s disease whdh.com/news/researc... via @7NEWS

Researchers at Mass. General Brigham gaining ground on Alzheimer’s disease - Boston News, Weather, Sports | WHDH 7News

BOSTON (WHDH) - Some talented researchers at Mass General Brigham are gaining ground in the fight against Alzheimer’s through a new approach that manipulates molecules<a class="excerpt-read-more" href...

whdh.com

Congratulations to Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍 www.sciencedirect.com/science/arti...

Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins

Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…

sciencedirect.com