Steve Turner
@sjturn.bsky.social
Immunologist @MonashUni, Head of Dept Microbiology, Past President of @ASImmunology; Trying to work out how immunity works, in particular T cells #Tcellsarecool #immunosky
What is T cell exhaustion? Good question! For some answers, feel free to read our recent review out in @cp-trendsimmuno.bsky.social. Co-authored with @danielutzschneider.bsky.social who made writing this review a great learning experience and a lot of fun. www.sciencedirect.com/science/arti...
sciencedirect.com
Dr. Marc K. Jenkins is a scientific hero for so many of us. And just a man who loves to sing Johnny Cash for some. Please join us in celebrating his extraordinary career with a retirement symposium at the University of Minnesota on Monday, September 14th! 🎉 To learn more see link in post below👇:
Great to share our recent review, written with @niclag.bsky.social and @danielthiele1.bsky.social @monashuniversity.bsky.social #monashBDI The evolving biology of T cell memory: A dynamic continuum of function and persistence | Science Immunology www.science.org/eprint/95PIC...
The evolving biology of T cell memory: A dynamic continuum of function and persistence
Advances in technology continue to refine our understanding of CD8 T cell memory, with major implications for next-generation vaccines and therapies.
science.org
Wonderful study, if you are into B cells or T cells, or better yet, both, do yourself a favour and give this a read!
Daniel Utzschneider@danielutzschneider.bsky.social · last mo.Thrilled to share our newest study led by @categraca.bsky.social and @yannick-alexandre.bsky.social published in @cp-immunity.bsky.social Here, we identify B cells as critical helpers for T cells to obtain effector function through enhancing IFN-I 😳 url.au.m.mimecastprotect.com/s/NE67C6X1Py...
From neoantigens to T cell biology: the Afternoon for Immunology returns on June 29. Join researchers from across Berlin for talks and discussion, including a keynote by Paul Klenerman (University of Oxford). Program & registration: 👉 www.mdc-berlin.de/news/events/... 👈 #mdcBerlin #Immunology
This is very cool
Marieke Oudelaar@mariekeoudelaar.bsky.social · 2mo ago📣 Preprint alert! We developed a method to analyze concurrent interactions between multiple chromatin regions at single alleles at sub-nucleosome resolution (multi-way Micro-Capture-C, mwMCC) & used this to study structural synergy within super-enhancers. 1/14 www.biorxiv.org/content/10.6...
Do you like beach, summer, Greek food AND T cells??? Then please join us for the 1st Aegean conference on T cells in health and disease aegeanconferences.org/conferences/... Registration closes soon (June 15th)!!!
We welcome the Federal Government's Budget commitment to fully deploy the Medical Research Future Fund – a landmark moment for Australian science. 🔗https://ow.ly/TwFh50YYwyE #MRFF #FederalBudget2026
👇new study alert! www.biorxiv.org/content/10.6... Wine and cheese gets better and better when it has time to ripen. So did this study. We searched for the rules that regulate the reshaping of the T cell proteome upon activation. Both sequence features in mRNA and RBPs were identified.
biorxiv.org
Great work from @taylahjbennett.bsky.social as part of her PhD studies. GILZ consistently emerges as a top hit in RNA‑seq analyses of T cell responses, including our own, we thought we'd take a look at what it does... Thanks to @jimmunol.bsky.social for highlighting.
The Journal of Immunology@jimmunol.bsky.social · 3mo agoData demonstrate that glucocorticoid-induced leucine zipper (GILZ) acts as a checkpoint for naïve CD8+ T cell by establishing a threshold for activation. Modulation of GILZ could be beneficial in improving CD8+ T cell responses to tumor antigens. 🔗 https://ow.ly/VGfn50YNAvg
🧬🧬💥💥 I am excited to share a new preprint from our lab “Multi-omic gene regulatory networks informed by 3D chromatin architecture reveal insights into hematopoietic stem cell ageing”. www.biorxiv.org/content/10.6... This is a labour of love by Quinn Stacpoole as part of his PhD.
biorxiv.org
‘Medical research isn't just good for our health, it's also great for our economy.’ In this Budget, the govt has to commit to spending money put aside for that purpose in the Medical Research Future Fund. Before we lose more brilliant minds overseas, before we damage the sector irrevocably.
theaustralian.com.au
Hearing from Dr Yue Qu about biofilms and hospital infections. Problem for AMR. Consist of metabolically inactive bacteria (issue for antibiotic uptake), can over come with nano wires that pierce bacterial cells to kill them, similar to dragonfly wings or skin of geckos natureiscool #scienceyeah
Epigenetics Update - Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains bit.ly/3NmLO5Q Edwina McGlinn and Chen Davidovich (Monash University) reporting in Mol Cell #Epigenetics #PRC2 #H3K27me3 --- Perfect for cancer, immunology, and aging; epigenometech.com
Finally someone did a nice characterization of TSC22D3 (GILZ) in T cell activation I know you T cell omics people have been wondering
Steve Turner@sjturn.bsky.social · 5mo ago1/ Great to highlight our new paper led by @taylahjbennett.bsky.social from her grad work in my lab. We looked how the transcription factor GILZ works as a restraint for T cell activation. A collaboration with Sarah Jones, School Clinical Science @monashuniversity.bsky.social doi.org/10.1093/jimm...
1/ Great to highlight our new paper led by @taylahjbennett.bsky.social from her grad work in my lab. We looked how the transcription factor GILZ works as a restraint for T cell activation. A collaboration with Sarah Jones, School Clinical Science @monashuniversity.bsky.social doi.org/10.1093/jimm...
Glucocorticoid-induced leucine zipper is a primary checkpoint molecule that establishes a virus-specific CD8+ T-cell activation threshold
Abstract. Naïve CD8+ T-cell activation needs to overcome a signaling threshold to initiate the resulting program of T cell proliferation and differentiatio
doi.org
Standing room only at the @monashuniversity.bsky.social Microbiology seminar today. Hearing from Bob Leung and his work on microbial communities found on the bark of trees and their role in regulating greenhouse gases www.science.org/doi/10.1126/... Amazing science!
Bark microbiota modulate climate-active gas fluxes in Australian forests
Recent studies suggest that microbes inhabit tree bark, yet little is known about their identities, functions, and environmental roles. Here we reveal, through gene-centric and genome-resolved metagen...
science.org
Last day of #Lornegenome. A great venue, cool talks and discussions. Learnt about diversification of mammalian genomes, inheritance of mutations and impact of mutagens, how TFs direct chromatin organisation and so much more. New collaborations, new projects, can’t wait til next year
Fantastic new paper from @the-de-lab.bsky.social showing how the CMV m11 protein drives immune evasion by blocking CD44-dependent, FRC-mediated DC migration in the spleen, ultimately dampening antiviral CD8⁺ T cell priming @monashuniversity.bsky.social www.nature.com/articles/s41...
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 - Nature
CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune r...
nature.com
The government can’t claim that medical research is a priority while failing to treat it as one. Nine in 10 leading researchers in Australia are missing out on government support for world‑class proposals, leaving exceptional talent uncertain about their future.
Most researchers miss out on innovation grants while medical fund sits on $25b
Nine in 10 Australian researchers had their “ideas grant” applications rejected last year, even as Australia’s medical investment fund sits on $5 billion more than it was designed to hold.
theage.com.au
Think climate change won’t touch you? Next time a mosquito bites, consider what it might be carrying. As temperatures rise, mosquitoes and other vectors expand their range, bringing viruses like dengue, yellow fever, and malaria (among others) closer to home. Important thread👇
Colin Carlson@colincarlson.bsky.social · 8mo agoNSF is about to dismantle NCAR at Russell Vought's direction to protect the fossil fuel industry. It's hard to communicate just how much NCAR does, so let's take a look: I've never worked at NCAR, and I've worked with NCAR researchers once ever. What scientific discoveries has NCAR made possible? 👇
NSF is about to dismantle NCAR at Russell Vought's direction to protect the fossil fuel industry. It's hard to communicate just how much NCAR does, so let's take a look: I've never worked at NCAR, and I've worked with NCAR researchers once ever. What scientific discoveries has NCAR made possible? 👇
Curiosity sparked it all, and that curiosity just earned one of science’s highest honors. In the Australian, rb.gy/cdwmki Yet government funding for curiosity-driven science is at an all-time low. Success rates are plummeting. If we don’t invest in curiosity, we risk losing the next big discovery.
A year in review at the Biomedical Discovery Institute @monashuniversity.bsky.social a great place to do discovery research that drives transformations in science and health #discoveryresearchmatters #fundresearchproperly
Me at meetings while still waiting on proofs of an accepted manuscript to arrive in my inbox... #comeon #academiclimbo #excitementbuilding
a close up of a woman 's face in a dark room
ALT: a close up of a woman 's face in a dark room
media.tenor.com
