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Mark Hartmann

@mphartmann.bsky.social

Scientist at DKFZ and NCT Heidelberg #epigenetics #stemcells #leukemia #colorectalcancer #multiomics #precisiononcology #oncofetal #reprogramming #plasticity www.translational-cancer-epigenomics.de

98 Posts1856 Follower4416 Folgt
Mark Hartmann@mphartmann.bsky.social · 4mo ago

Editors’ Pick by Cancer Research Catalyst @aacrjournals.bsky.social RAS-driven plasticity and oncofetal reprogramming as a key mechanism and vulnerability in JMML. The article is freely available for a limited time: www.aacr.org/blog/2026/03... #hematology #oncology #epigenetics #development

Editors’ Picks, March 2026: Pediatric Leukemia Development, Low-dose Tamoxifen Use, and More

In March, AACR's journals editors highlighted studies on the development of pediatric leukemia, the use of low-dose tamoxifen, and more.

aacr.org

Mark Hartmann@mphartmann.bsky.social · 4mo ago

Excited to present our work at the 2026 #ISEH Mini Symposium! “Beyond the Maturation Block: Oncofetal Reprogramming and Stem Cell Plasticity in Pediatric Leukemia” Join us on April 16 to discuss developmental programs in leukemia and beyond. iseh.org/Webinars-Eve...

Mini Symposium

iseh.org

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 4mo ago

We are excited to announce the full Mini Symposium program featuring the short talks selected from submitted abstracts! Don't miss the chance to view groundbreaking research and choose the top short talk. View the full program and register ➡️ iseh.org/Webinars-Eve...

Mark Hartmann@mphartmann.bsky.social · 6mo ago

New Spotlight in @aacrjournals.bsky.social #Oncogene × #Ontogeny × #Plasticity shape leukemia biology & therapy response. Two complementary studies show: mutations alone don’t explain disease behavior—developmental state and cellular plasticity matter. aacrjournals.org/bloodcancerd... 🩸🧬 EpiSci

A Triumvirate of Transformation: Oncogene, Ontogeny, and Plasticity

Summary:. Cancer cells display extensive heterogeneity that influences therapy response and clinical outcome, yet the underlying mechanisms remain incompletely understood. Recent studies reveal that t...

aacrjournals.org

Rhys Morgan@rhysmorganlab.bsky.social · 6mo ago

Very pleased to share our latest pre-print which showcases the incredible hard work and skill of Dr Okan Sevim. Our continued exploration of β-catenin's contribution to the post transcriptional landscape of blood cells led us to a LIN28B interaction. 1/7 www.biorxiv.org/content/10.6...

Dual targeting a LIN28B:β-catenin axis in acute myeloid leukaemia

Wnt/β-catenin signalling is dysregulated across several haematological malignancies, including acute myeloid leukaemia (AML), where is lacks effective targeting strategies. Previously, we discovered that β-catenin interacts with several RNA-binding proteins (RBP), and binds mRNA indirectly, indicating contributions to the post-transcriptional landscape of leukaemia cells. Here, we found the most frequent RBP-binding motif amongst β-catenin-bound mRNAs was the GGAG motif targeted by the oncofoetal expressed miRNA-regulating RBP LIN28B. We detected the β-catenin:LIN28B interaction in lymphoid and myeloid cell lines, and primary human CD34⁺ fetal liver-derived haematopoietic stem cells. LIN28B positively regulated Wnt signalling capacity by regulating LEF1 expression through a post-transcriptional mechanism requiring the let7 miRNA axis. Further miRNA sequencing of β-catenin- and LIN28B-depleted myeloid cells revealed both potential cooperative and antagonistic function in miRNA regulation. Finally, dual-targeting both β-catenin and LIN28B through either genetic or pharmacological means preferentially killed AML cells. These data reveal a potential novel synthetically lethal relationship in AML which could be exploited in the rare AML subsets where LIN28B expression becomes reactivated ### Competing Interest Statement The authors have declared no competing interest. Kay Kendall Leukaemia Fund, https://ror.org/03j2wfg84, KKL1051, KKL1446 Leukaemia & Myeloma Research UK, 4-5/06.21R Children’s Cancer & Leukaemia Group, CCLGA 2023 16 Morgan Republic of Türkiye Ministry of National Education

biorxiv.org

Reka Toth@rn-toth.bsky.social · 7mo ago

🚨We have an opening for Data Scientists or Bioinformaticians using machine learning and AI with all kinds of molecular data to support cancer research. 🧬 Permanent position, fantastic team, exciting projects—what more could you ask for? www.lih.lu/en/job/?valu...

Job » Luxembourg Institute of Health

Applications including a letter detailing your motivation and a curriculum vitae should be sent through our website via the apply button below.

lih.lu

Andi Roy@roylab-oxford.bsky.social · 7mo ago

Out in print this week @bloodjournal.bsky.social . Very proud of this collaborative work with Prof Karadimitris @imperialimmuno.bsky.social. Thanks to @cancerresearchuk.org and CwC_UK for funding this work. #InfantALL @paediatrics.ox.ac.uk @imm.ox.ac.uk

Blood Journals Portfolio@bloodjournals.hematology.org · 7mo ago

Off-the-shelf bispecific CD133-CD19 CAR-iNKT cells eradicate CAR antigen–high and –low medullary and leptomeningeal KMT2Ar ALL. Read in Blood: buff.ly/HIlsUq7 #ALL #BloodJournal

Mark Hartmann@mphartmann.bsky.social · 7mo ago

Interesting story about the role of #oncofetal RNA-binding proteins in #immune #evasion in #ovarian #cancer.

Signal Transduction and Targeted Therapy@sigtrans-sttt.bsky.social · 7mo ago

Scientists identify #IGF2BP1 as a driver of #ImmuneEvasion in C5 #OvarianCancer, suppressing IFN‑γ–IRF1–MHC‑I signaling and T‑cell infiltration; its inhibition restores #antitumor immunity and boosts #PD1blockade. @unihalle.bsky.social #OpenAccess in #STTT: doi.org/10.1038/s413...

Arnaud Krebs@arnaudkr.bsky.social · 7mo ago

Epigenetics that matters! Very cool work on hard to hard-to-access cell types . Finally some solid epigenetics examples that should be used in textbooks! Congrats to Mathieu and team @embl.org Rome!

Jamie Hackett@jamiehackett.bsky.social · 7mo ago

This went under the radar but answers a fundamental question in Epigenetics... From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How? Outstanding work from Mathieu Boulard and colleagues www.biorxiv.org/content/10.6...

Mark Hartmann@mphartmann.bsky.social · 10mo ago

Pipeline Olympics for DNA methylation data Check this out: doi.org/10.1093/nar/... Important study from @rn-toth.bsky.social & @pavlolutsik.bsky.social Published @narjournal.bsky.social #epigenetics #methylation #bioinformatics

Pipeline Olympics: continuable benchmarking of computational workflows for DNA methylation sequencing data against an experimental gold standard

Abstract. DNA methylation is a widely studied epigenetic mark and a powerful biomarker of cell type, age, environmental exposures, and disease. Whole-genom

doi.org

Mark Hartmann@mphartmann.bsky.social · last yr.

The German Science and Humanities Council declares permanent positions the new standard. Interview with @wickwolfgang.bsky.social & Insa Großkraumbach @wissenschaftsrat.de A must-read for all working in higher education and research in Germany! #Wissenschaft #Forschung #WissZeitVG #IchBinHanna

Jan-Martin Wiarda@jmwiarda.bsky.social · last yr.

Schluss mit "Up or Out" Der Wissenschaftsrat erklärt Dauerstellen zum Regelfall. Ein Paukenschlag vor der Novelle des Wissenschaftszeitvertragsgesetzes. Im Interview erklären Wolfgang Wick und Insa Großkraumbach, was das bedeutet. Im Wiarda-Blog: www.jmwiarda.de/blog/2025/07...

Mark Hartmann@mphartmann.bsky.social · last yr.

Der @wissenschaftsrat.de fordert einen Kulturwandel im Wissenschaftssystem: moderne Personalstrukturen, attraktive Karrierewege, mehr Dauerstellen. Ein längst überfälliger und wichtiger Schritt. www.wissenschaftsrat.de/SharedDocs/P... #Wissenschaft #Forschung #WissZeitVG #Hochschulpolitik

Pressemitteilungen - Die Wissenschaft braucht moderne Personalstrukturen und mehr Dauerstellen | WR gibt Anstoß für einen Kulturwandel

Der Wissenschaftsrat (WR) fordert eine grundlegende Reform der Personalstrukturen im deutschen Wissenschaftssystem. Das Ziel sind attraktive, vielfältige Stellen mit klar strukturierten Entwicklungsoptionen, die die Wissenschaftseinrichtungen in der Konkurrenz um Fachkräfte sowie im internationalen Wettbewerb stärken. Nötig ist ein Personalgefüge, das den immer stärker ausdifferenzierten Anforderungen an die und aus der Wissenschaft gerecht wird und attraktive Dauerstellen ergänzend zur Professur bietet.

wissenschaftsrat.de

Adlung Lab@adlunglab.com · last yr.

🦎 Differential expression analysis relies on cluster identities, unless you perform a regression along continuous representation in latent space. LEMUR from @const-ae.bsky.social & @wkhuber.bsky.social does that neatly for scRNA-seq data! 🔗 doi.org/10.1038/s415... 🧪 @naturegenet.bsky.social

Analysis of multi-condition single-cell data with latent embedding multivariate regression

Nature Genetics - Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction...

doi.org

Mick Milsom@milsommick.bsky.social · last yr.

Outstanding contributions to our field and society acknowledged with this year’s ISEH awards. Presentations and award seminars at this year’s annual meeting in Kumamoto iseh.org/page/iseh2025

ISEH 2025 - International Society for Experimental Hematology

ISEH 54th Annual Scientific Meeting

iseh.org

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · last yr.

ISEH is thrilled to announce the recipients of the 2025 Society Awards, which will be presented at the ISEH 54th Annual Scientific Meeting. Read more about each award recipient on www.simplyblood.org

Mark Hartmann@mphartmann.bsky.social · last yr.

Reprogramming, plasticity, safeguards… exciting topic and fantastic story! Great to see this out - Congratulations to all of you! Must read! #OncoSky

Moritz Mall@moritzmall.bsky.social · last yr.

Our findings show that active repression preserves cell identity. PROX1 is just one example—uncovering more #SafeguardRepressors could reshape regenerative medicine & cancer therapy. Stay tuned for what’s next! 🚀 #CancerTherapy #StemCells www.embopress.org/doi/full/10....