Our new paper is out this week in Nature Immunology. This work was preformed at @lji.org, in collaboration with the Irvine and Schief labs at Scripps Research, and guided by my mentor, @profshanecrotty.bsky.social . Grateful to be able to finally share it publicly! www.nature.com/articles/s41...

Rapid boosting increases germinal center responses to sequential vaccines - Nature Immunology

The authors explore the potential of changing vaccination schedules combined with ‘germline targeting’ to increase the generation of broadly neutralizing antibodies against HIV. In mice, they find tha...

nature.com

Preprint: Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans @profshanecrotty.bsky.social @hannahdstacey.bsky.social www.biorxiv.org/content/10.1...

After 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people. * "Tier 2" neutralizing antibodies, induced consistently. www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models

An HIV envelope trimer mRNA vaccine enables membrane-bound expression and produces a functional immunogen in preclinical mammalian models.

science.org

In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/... @scienceimmuno.bsky.social @lji.org

Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates

Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies.

science.org

Happy to share our latest work! This study would not have been possible without the amazing Crotty Lab team, our collaborators at the Scripps CHAVD HIV vaccine consortia, and crucial support from NIH funding. Grateful to be part of this effort!

Prof. Shane Crotty@profshanecrotty.bsky.social · 9mo ago

In our latest study in @cp-immunity.bsky.social, we followed dynamics of vaccine-specific Tfh cells for 60+ weeks after immunization. authors.elsevier.com/a/1m3mV3qNrU... We captured >500,000 CD4 T cells including >36,000 vaccine-specific Tfh by scRNAseq, giving an unprecedented longitudinal detail.

This week in #Science #Immunology: A comprehensive review from Darrell Irvine and co-authors on recent advances in understanding #vaccine #adjuvant mechanisms of action, which could guide adjuvant design for vaccines against emerging and challenging pathogens:

Linking vaccine adjuvant mechanisms of action to function

We review mechanisms of action underlying the function of vaccine adjuvants and knowledge gaps to be addressed.

science.org