Sudipta Mukherjee

@sudimukherjee.bsky.social

Tissue mechanics and brain development @EBM @FAU Erlangen-Nuremberg PhD @Franze lab @University of Cambridge Masters @Sonawane lab @TIFR Mumbai

Presenting our latest results!! Glad to have been part of the team! Huge thanks to everyone especially @evapillai.bsky.social @niklasgampl.bsky.social and @franzelab.bsky.social !!! #xenopus #mechanobiology

Franze Lab@franzelab.bsky.social · 7mo ago

Paper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM

When a larval zebrafish twitches its tail, the vascular endothelium lights up with a calcium signal, mediated by Piezo1. We used to think mechanosensing in endothelial cells was about sensing blood flow, but at least in this case it's about sensing body motion.

Thanks,DionnHargreaves LabWoolner @dev-journal.bsky.social for highlighting our preprint! Curious how mechanical and chemical signaling guides axons or how frogs are excellent for this question? @franzelab.bsky.social @evapillai.bsky.social🐸🧠 check it out #xenopus #Devbio #mechanobiology

Eva Pillai@evapillai.bsky.social · last yr.

Thank you Dionn Hargreaves, Sarah Woolner & @dev-journal.bsky.social for highlighting our @sudimukherjee.bsky.social @franzelab.bsky.social preprint! Chuffed to see it engaged with through fresh eyes! 🙌 Interested in how mechanical & chemical signals shape tissue development? Give it a look! 🧠🐸⚙️

So excited that our latest work is out! We have been working to understand how damaged tissue exits regeneration and returns to normal gene expression, and found a major role for the pioneer transcription factor Zelda in flies. Kudos to @anishbose.bsky.social @keatonschuster.bsky.social et al!

The pioneer transcription factor Zelda controls the exit from regeneration and restoration of patterning in Drosophila

The pioneer factor Zelda activates a specific set of developmental and structural genes to end tissue regeneration.

science.org

“Our comprehensive atlas serves as a valuable resource to the cardiovascular and regeneration scientific communities and their ongoing efforts to understand the molecular and cellular mechanisms underlying vertebrate heart regeneration.” New work from Ying Su Lab 🇨🇳 🔗 www.nature.com/articles/s41...

An organ-wide spatiotemporal transcriptomic and cellular atlas of the regenerating zebrafish heart - Nature Communications

Adult zebrafish possess the ability to regenerate injured hearts through a complex orchestration of molecular and cellular activities. Here, the authors present a single cell and spatially-resolved at...

nature.com

“Together, our results establish this optogenetic toolkit as a potent experimental platform to rapidly, directly, and adjustably activate FGF, BMP, and Nodal signaling in zebrafish embryos.” New work from @leanneiannucci.bsky.social & @katwrog.bsky.social 🔥

bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · last yr.

An optogenetic toolkit for robust activation of FGF, BMP, and Nodal signaling in zebrafish https://www.biorxiv.org/content/10.1101/2025.04.17.649426v1

Are material phase transitions more than simple regulators of tissue deformability? Check our latest work uncovering that rigidity transitions can trigger cell polarity! Congratulations to @laura-rustarazo.bsky.social , @crisp-c.bsky.social and Adrián for leading this work!

Laura Rustarazo-Calvo@laura-rustarazo.bsky.social · last yr.

🎉 Excited to share our new work: “Adhesion-driven tissue rigidification triggers epithelial cell polarity”, now on @biorxivpreprint.bsky.social ! A huge thank you to @nicolettapetridou.bsky.social, Bernat, @crisp-c.bsky.social, Adrián, and everyone involved! 🙌 🧵⤵️