Happy to finally see this out in a peer-reviewed form 🧬🌱 Congrats to everyone who contributed! www.nature.com/articles/s41...

The dual trxG/PcG protein ULTRAPETALA1 modulates H3K27me3 and directly enhances POLYCOMB REPRESSIVE COMPLEX 2 activity for fine-tuned reproductive transitions - Nature Plants

This study reports a bivalent factor, ULTRAPETALA1, that can counteract as well as promote PRC2 activity at hundreds of developmental genes in Arabidopsis thaliana. The pro-PRC2 activity of ULTRAPETAL...

nature.com

Our new Review is out now! @carolinedean.bsky.social @miguelmontez.bsky.social We discuss how plants monitor seasonal temperature exposure, highlighting interconnected mechanisms of short-term transcriptional regulation & long-term epigenetic memory rdcu.be/fnLmG 🌱❄️

So happy and proud to share our lab’s first #plantscience research article, revealing that angiosperms have the capacity to encode memory of flooding stress. A heroic effort by @aidamaric.bsky.social in collaboration with @djgibbs.bsky.social and others. A brief 🧵 www.biorxiv.org/content/10.6...

I am happy to organise this RECROP workshop on June 30 and July 1st in Brno, Czech Republic. Registrations are now open. Early researchers who are RECROP members may apply for a travel grant. Beware of the deadlines! bit.ly/47gUQbA www.recrop-cost.com @ceitec.eu

“I think it’s a real mistake to forget where the pipeline for all this begins.” John Diffley reflects on the importance of basic research, his mission to decode DNA replication and recreate it in the lab, and the scientific optimism of the 1960s that helped shape it. www.crick.ac.uk/news/2026-03...

Excited to see this review out, by Caroline Dean and Martin Howard @johninnescentre.bsky.social. I really enjoyed being part of the discussions shaping it over the past few months - worth a read 👇

Graded versus ON/OFF control in quantitative gene expression and epigenetic memory - The EMBO Journal

How can expression of a specific gene be quantitatively regulated? In this review, we discuss two possible modalities. In one, the level of mRNA generated from each gene copy can be smoothly varied gi...

link.springer.com

I attended this course during my PhD and highly recommend it!

North American Arabidopsis Steering Committee@naascarabidopsis.bsky.social · 5mo ago

please share! 🌱Application deadline is March 27 to apply for the Cold Spring Harbor Frontiers and Techniques in Plant Science 3 week summer course! 🌱 It's a great time- you learn a lot and really bond with others in the course. 🌱 I was in the class of 2000! 😀 meetings.cshl.edu/alumni.aspx?...

The unique environment provided by #CristaleraUAM made the experience even more unforgettable

Last week was very special. We hosted in Madrid the second edition of "Chromatin and Transcription: FLC and beyond", gathering Caroline Dean alumni and fellow researchers working on chromatin, transcription, and epigenetics @cbgpmadrid.bsky.social @johninnescentre.bsky.social

Call for papers! To celebrate the upcoming edition of the Chromatin and Transcription: FLC and beyond II meeting in Madrid, I am co-editing with the great @jiquesta.bsky.social and Prof Zhe Wu from @sustech.bsky.social a Research topic for @frontiersin.bsky.social Plant Science (1/n)...

📣 Looking for a 3-Year Postdoc @johninnescentre.bsky.social to join my Wellcome project. This is a highly interdisciplinary project that explores chromatin dynamics in 🌱 plant responses across timescales, from circadian rhythms to seasonal changes 📅 Closes on 10 Dec. www.jic.ac.uk/vacancies/36...

Postdoctoral Researcher (Dr Miguel Montez) | John Innes Centre

An exciting opportunity has arisen for a Postdoctoral Researcher to join the Wellcome Trust project led by Dr Miguel Montez and hosted within the Dodd Group at the John Innes Centre.

jic.ac.uk

1/ 🚀 AEBP2 isn’t what we thought. You were told that AEBP2 promotes PRC2 activity on chromatin. We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity. 👉 surl.li/cgwqcq A thread 🧵

Our paper on VEL-dependent polymerization is featured on the cover of this month's issue of @cp-molcell.bsky.social 🎉 The cover art was created by my talented friend Awesta - the result of hours of brainstorming together over video. Great fun teaming up for this!

Anna Schulten@sulteavn.bsky.social · 11mo ago

Excited to share the paper from my work in the Dean lab @johninnescentre.bsky.social out now in @cp-molcell.bsky.social. Huge thanks to all the co-authors - it was a great collaborative effort! Watch out for the associated cover artwork coming out next week 🎉 www.cell.com/molecular-ce...

NEWS - Professor Yiliang Ding awarded prestigious Royal Society Faraday Discovery Fellowship These long-term @royalsociety.org awards are worth £8m over 10 years to support exceptional mid-career research leaders in the UK. Congratulations @yiliangding.bsky.social 👏 👉 www.jic.ac.uk/press-releas...

Excited to share the paper from my work in the Dean lab @johninnescentre.bsky.social out now in @cp-molcell.bsky.social. Huge thanks to all the co-authors - it was a great collaborative effort! Watch out for the associated cover artwork coming out next week 🎉 www.cell.com/molecular-ce...

VEL-dependent polymerization maintains the chromatin association of Polycomb proteins for the switch to epigenetic silencing

Schulten et al. show that VEL polymerization domains produce higher-order protein assemblies to maintain chromatin association of Polycomb proteins, enabling a stable epigenetic switch at the floral r...

cell.com

The final version of our paper showing VRN2-PRC2 mediated control of PIF4 signalling is now published in the latest issue of Developmental Cell @cellpress.bsky.social. Many thanks to Zhe Wu for writing an accompanying Preview piece summarising the work, here: www.cell.com/developmenta...

PRC2-mediated repression of PIF4 targets beyond the on/off switch of gene expression

In this issue of Developmental Cell, Osborne et al. report that the angiosperm-specific polycomb repressive complex 2 (PRC2) subunit VERNALIZATION 2 (VRN2) regulates leaf growth by stable deposition o...

cell.com

The new issue of @newphyt.bsky.social features a profile of Caroline Dean: 👉 nph.onlinelibrary.wiley.com/doi/10.1111/... #PlantScience #PlantEpigenetics #PlantLuminaries

Big congratulations to @kellythd-nguyen.bsky.social 👍👍👍Super beautiful structure👍👍👍Very happy to contribute some RNA structure work to this great collaboration😊 @johninnescentre.bsky.social @mrclmb.bsky.social

Kelly Nguyen@kellythd-nguyen.bsky.social · last yr.

Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social. www.science.org/doi/10.1126/...

Just dropping this here in case anyone is interested in joining 🙃

Happy to see our latest paper by @drosborneplantsci.bsky.social et al out today in Developmental Cell @cellpress.bsky.social! We identify a role for VRN2-PRC2 in regulating light-responsive growth in Arabidopsis through the conditional epigenetic repression of PIF signalling. tinyurl.com/swbyff24

VRN2-PRC2 facilitates light-triggered repression of PIF signaling to coordinate growth in Arabidopsis

Osborne et al. show that the angiosperm-specific PRC2 subunit VRN2 is enriched in hypoxic regions of the Arabidopsis shoot, where it is required for stable deposition of H3K27me3 in key PIF4 target ge...

tinyurl.com

Our paper has been published! We used in vivo single-particle tracking to demonstrate that the assembly of core FCA oligomers into functional macromolecular condensates. Thanks to all the authors and colleagues!

The EMBO Journal@embojournal.org · last yr.

In vivo single-particle tracking by Geng-Jen Jang, Caroline Dean et al reveals the modular assembly of #Arabidopsis gene expression regulator FLOWERING CONTROL LOCUS A from oligomers into molecular condensates competent for RNA 3’-processing www.embopress.org/doi/full/10....

In vivo single-particle tracking by Geng-Jen Jang, Caroline Dean et al reveals the modular assembly of #Arabidopsis gene expression regulator FLOWERING CONTROL LOCUS A from oligomers into molecular condensates competent for RNA 3’-processing www.embopress.org/doi/full/10....

We are happy to share our work on local #nucleosome dynamics integrating #temperature inputs into an #epigenetic switching mechanism. ⚠️ Preprint alert!! www.biorxiv.org/content/10.1...

Cold-induced nucleosome dynamics linked to silencing of Arabidopsis FLC

Temperature influences nucleosome dynamics, and thus chromatin, to regulate gene expression. Such mechanisms underlie the epigenetic silencing of Arabidopsis FLOWERING LOCUS C (FLC) by prolonged cold....

biorxiv.org

I've written a commentary for Cell Systems arguing that biology needs to find a way to communicate its complexity from the outset, rather than starting with simple but misleading narratives. It's free to view and download here (until 1 April). authors.elsevier.com/a/1karS8YyDf...