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Vangeli Geshkovski

@vgeshkovski.bsky.social

Postdoc at The Sainsbury Lab, Norwich | Nobori Group | chromatin & immunity 👨‍🔬🌱🧬🦠 PhD from CEA/LPCV Grenoble

234 Posts563 Follower552 Folgt
Cristel Carles@cristelcarles.bsky.social · 14h ago

Bravo, Vangeli, on this first-author paper, which beautifully launches your career as a young researcher. It has been a pleasure to share this PhD journey with you, marked by memorable scientific exchanges.

Vangeli Geshkovski@vgeshkovski.bsky.social · yesterday

Happy to finally see this out in a peer-reviewed form 🧬🌱 Congrats to everyone who contributed! www.nature.com/articles/s41...

The dual trxG/PcG protein ULTRAPETALA1 modulates H3K27me3 and directly enhances POLYCOMB REPRESSIVE COMPLEX 2 activity for fine-tuned reproductive transitions - Nature Plants

This study reports a bivalent factor, ULTRAPETALA1, that can counteract as well as promote PRC2 activity at hundreds of developmental genes in Arabidopsis thaliana. The pro-PRC2 activity of ULTRAPETAL...

nature.com

Arnau Sebé-Pedrós@arnausebe.bsky.social · 3d ago

Happy to share the final version of our study on the evolution of chromatin states across eukaryotes, out today in @natgenet.nature.com Led by @crisnava.bsky.social and @seanamontgomery.bsky.social www.nature.com/articles/s41... Some highlights below

Diversity and evolution of chromatin regulatory states across eukaryotes - Nature Genetics

This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

nature.com

Joris Sprakel@jorissprakel.bsky.social · 2w ago

How do transcription factors bind DNA strongly, and in a switch like manner, while remaining sequence specific? Our new paper on a canonical plant TF suggests the answer is a previously underappreciated assembly state: transcription factor nanoclusters. www.science.org/doi/10.1126/...

Nanoclustering of a plant transcription factor enables strong yet specific DNA binding

Transcription factor nanoclusters balance the DNA binding trade-off between weakly binding oligomers and nonspecific condensates.

science.org

Benoit Bruneau@benoitbruneau.bsky.social · 2w ago

our paper starts with an analysis of the dynamics of 3D chromatin in cardiac differentiation, for ventricular and atrial cardiomyocytes. They are different! And by single cell methyl-HiC we can discern subtype differences. www.science.org/doi/10.1126/...

Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor

Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell type–specific gene regulation is linked to the reorganization of three-dimensio...

science.org

Alex Radzisheuskaya@a-radzisheuskaya.bsky.social · 4w ago

1/ Very excited to share the first publication from my lab! In this work, we developed an efficient strategy to precisely mutate mammalian histone genes in their native genomic context using CRISPR prime editing: www.nature.com/articles/s41...

Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing - Nature Genetics

This study uses a precise and efficient clustered regularly interspaced short palindromic repeats (CRISPR) prime editing system to substitute lysine residues in histone H3, individually or in combinat...

nature.com

Nick Talbot@talbotlabtsl.bsky.social · last mo.

PhD position in my group for entry in October 2026. Round 3 of the @nrpdtp.bsky.social BBSRC competition. Please RT👇 biodtp.norwichresearchpark.ac.uk/projects/van...

Vanishing Virulence: Investigating pathogenicity loss in a plant pathogenic fungus (TALBOT_S26DTP3) | Doctoral Training Partnership

What makes a plant killer lose its edge? This project will investigate why fungal pathogens lose virulence when they are grown in laboratory culture away from their host plant. Use cutting-edge…

biodtp.norwichresearchpark.ac.uk

Jake Harris@c-jake-harris.bsky.social · last mo.

Excited to be able to advertise 1x postdoc and 2x technician positions to join my group in Cambridge working on an exciting ARIA funded project to help bring a plant artificial chromosome into existence! Reposts very welcome please 🙏 (1/2)

Chung Hyun Cho@chc-evobio.bsky.social · last mo.

Excited to share our new preprint led by Fred and me in collaboration with the archaeal community! We found that the molecular foundation of histone-based chromatin has pre-eukaryotic roots in Asgard archaea. (1/4) #ArchaeaSky www.biorxiv.org/content/10.6...

Emergence of histone-based chromatin complexity in Asgard archaea

The emergence of the eukaryotes coincided with the diversification of histone proteins and their post-translational modifications by enzymes that constitute the core of eukaryotic chromatin. Yet the e...

biorxiv.org

Aline Probst@alineprobst.bsky.social · last mo.

Have you ever wondered how the epigenome is modified during the transition from seed to seedling? Here, we show that water uptake by Arabidopsis seeds triggers the eviction of the H2B variant H2B.8, thereby revealing replication-independent chromatin reprogramming. www.nature.com/articles/s41...

Replication-independent eviction of the histone variant H2B.8 reveals chromatin reprogramming during seed imbibition - Nature Communications

The transition from seed to seedling requires chromatin reprogramming. By studying the histone variant H2B.8, the authors show that it organizes silent chromatin in dry seeds and reveal that water upt...

nature.com