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Jacob Smith

@jacobsmithsci.bsky.social

PI @UniBarcelona @IBUB_UB. https://sites.google.com/view/smithlab-ibub/home?authuser=0 Circadian clocks and inter-organ crosstalk.

30 Posts923 Follower1006 Folgt
Sdelci Lab@sdelcilab.bsky.social · 5mo ago

New paper out in Nature Communications: www.nature.com/articles/s41... We found >250 metabolic enzymes on chromatin. Only ~20 had been reported before. This means hundreds of metabolic enzymes may have unexplored nuclear roles.

Native chromatome profiling reveals hundreds of metabolic enzymes in the nucleus across tissues - Nature Communications

Here proteomic chromatome analysis shows metabolic enzymes widely localize to chromatin in cancer in a tissue-specific manner. Nuclear enzymes affect DNA damage/repair and transcription, revealing non...

nature.com

Chris MacQuarrie @cmacquar.bsky.social · 7mo ago

Peer Review is broken because a generation of Editors were trained that peer review is sacrosanct. Thus we have Editors who are clerks, sending and re-sending manuscripts to reviewers until they are happy. That's not the job. Be an Editor, not a clerk. Use your skill and judgement. Make decisions.

Sdelci Lab@sdelcilab.bsky.social · last yr.

🚀 We’re excited to share our latest publication in collaboration with Verena Ruprecht's group at @crg.eu Mechanobiology meets Nuclear Metabolism www.nature.com/articles/s41...

Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects - Nature Communications

The authors uncover a mechano-metabolic adaptation where confinement induces rapid mitochondrial relocalization to the nuclear periphery, generating localized nuclear ATP surges that support chromatin...

nature.com

Jacob Smith@jacobsmithsci.bsky.social · last yr.

🧪 Really cool new #circadian paper looking at the role of the liver clock in inter-organ crosstalk with muscle during Cachexia "Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia": Cell www.cell.com/cell/fulltex...

Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia

Cancer-induced liver changes promote body wasting through secreted factors, with circadian regulators and hepatokines being important contributors to cancer cachexia.

cell.com

Jacob Smith@jacobsmithsci.bsky.social · last yr.

🧪 Encouraging to see people standing up against tyranny and fascism in the US. The Trump administration’s anti-science and pro-war agenda isn’t just dangerous at home — it threatens progress and stability worldwide. Enough!

Mark Hamill@markhamillofficial.bsky.social · last yr.

TODAY 6/14/25, we peacefully make our voices heard... NO KINGS!* 🇺🇸 *Also NO: CONVICTED FELONS/PATHOLOGICAL LIARS/DRAFT DODGERS/ADJUDICATED RAPISTS/SHORT-FINGERED VULGARIANS/MALIGNANT NARCISSISTS & ANYONE WHO INCITED AN INSURRECTION IN AN ATTEMPTED COUP AGAINST HIS OWN COUNTRY a/k/a TRAITORS ✊

Jacob Smith@jacobsmithsci.bsky.social · 2y ago

🧪 ✍️ Please check out our new review on intercellular and interorgan communication between circadian clocks ⏰🧬 out today in Nature Reviews Molecular Cell Biology 🎉 @natrevmcb.bsky.social ! Here is the SharedIt link for free access: rdcu.be/d5ppE

Circadian clock communication during homeostasis and ageing

Nature Reviews Molecular Cell Biology - Communication between the circadian clocks of different cell and tissue types supports the daily rhythms of homeostatic processes that maintain bodily...

rdcu.be

Itai Yanai@itaiyanai.bsky.social · 2y ago

It seems easy to make fun of basic science – for example why would you want to study bacterial immune systems? But then you would have to admit that that’s exactly what led to the discovery of using CRISPR as an insanely good technology for genome engineering.

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Jacob Smith@jacobsmithsci.bsky.social · 2y ago

It was great to speak at the Muscle, Exercise and Health symposium last week @InstitutCochin in Paris. A fantastic meeting! Thanks to the organisers and speakers- including keynotes Bente Pedersen, Helen Blau and Marco Sandri for amazing talks. #muscle #circadian #aging

Florence Niedergang@florenceniedergang.bsky.social · 2y ago

First post here to report on the awesome talk by Helen Blau @stanfordpress.bsky.social on #muscle aging and rejuvenation possibilities during the @institutcochin annual symposium! @cnrs.bsky.social @inserm.bsky.social @université-paris cité !

Itai Yanai@itaiyanai.bsky.social · 2y ago

The backbone of academia has always been ‘middle-class labs’ (as David Glanzman puts it): those medium-sized labs with reasonable funding and a dream of making a big discovery.

Dave Sayers@davesayers.eurosky.social · 2y ago

Academia runs on contacting other academics out of the blue and saying HEY do you wanna do this COOL THING for essentially NO REWARD and equally certainly NO RECOGNITION from your employer and those people going OH MAN that sounds AWESOME sign me up for the COOL NO REWARD NO RECOGNITION EXPERIENCE.