It’s been fantastic to have Mindy Nguyen here as our Saturday Morning Science summer student this year. Congrats on a fantastic job!!
Katherine King MD PhD
@thekinglab.bsky.social
Professor in Pediatric Infectious Disease researching effects of infection, inflammation, and the microbiome on hematopoietic stem cells and their progeny. How do infections affect bone marrow and vice versa? Co-Director of BCM MSTP. 🌈
Congrats to @bcm-mstp.bsky.social student Alice Wen and mentor C. Hermann for their paper this week in Science! www.science.org/doi/10.1126/...
Antibiotics stimulate protein transfer to persister cells
The exchange of biological matter between bacterial cells drives adaptation and evolution. However, whether bacteria can exchange functional proteins remains unclear. In this work, we found that antib...
science.org
Former fellow and now instructor Ajibike Lapite was awarded an inaugural LEAPS fellowship at TCH, providing 75% protected time for 2 years as she develops her K application. What a tremendous opportunity— congratulations Aji! #curingsicklecell @texaschildrens.bsky.social @bcmhouston.bsky.social
First annual Texas Children’s Research Institute symposium today— strong representation from the lab! The symposium had over 300 abstracts and I was honored to give the morning keynote. Very vibrant atmosphere.
Another Peds ID division research retreat in the books! Great science, laughs, and career advice— thanks to the organizers! @bcmhouston.bsky.social @texaschildrens.bsky.social
Thanks @isehsociety.bsky.social for highlighting our recent paper relating infection history to the emergence of clonal hematopoiesis! Super collab with Elizabeth Platz and the ARIC longitudinal study! @bcmhouston.bsky.social
What role does immune challenge play in selecting mutant hematopoietic clones? Read insights into infection frequency and CHIP risk: www.exphem.org/article/S030.... @thekinglab.bsky.social
Thanks Mick for highlighting our paper in press at J Exp Heme! This was an incredible opportunity to use longitudinal data on thousands of people with two sequencing time points 20 years apart to identify epidemiologic drivers of CH incidence. @bcmhouston.bsky.social @isehsociety.bsky.social
Bluesky
tisehsociety.bsky.social
First (to my knowledge) manuscript describing a correlation between number of infections and incidence of clonal hematopoiesis (CHIP). Really important from the perspective of highlighting a possible modifiable driver of CHIP during aging. @isehsociety.bsky.social www.exphem.org/article/S030...
Congrats to @bcm-mstp.bsky.social student Sean Hyslop on this honor! @bcmfromthelabs.bsky.social
Live from Québec 🇨🇦 - congrats to our Cancer Immunotherapy Keystone Symposia / NCI scholarship awardees: Allison Casey, Raphael Mattiuz, Richard Van, Sean Hyslop & Joan Shang 👏 Apply for 2027: keysym.us/KSCancerIO27 #KSCancerImmune26 @jguerriero.bsky.social @solangepeters.bsky.social
To my friends who are @keystonesymposia.bsky.social #hematopoiesis and #myeloid meetings— please check out two talks from my group TOMORROW: Ruoqiong Cao on central #trainedimmunity Thursday morning and Arushana Maknojia unravels #microbiome dependent hematopoiesis in the pm! 🔥🔥🔥
Visiting friends in science can be illuminating for the mind and refreshing for the soul. Thank you @ericpietras.bsky.social and Daniel Molosky for a fabulous visit!
Yahoo! I was the only girl in some of my classes in high school and college. Though we’ve come a long way, women are still a minority in science. Excited to see the blossoming careers of many young women in science today!
Happy International Day of Women and Girls in Science! 🧪 The EMBO Women in Science Lectures address issues related to gender and diversity in science. Find out more and apply here: https://www.embo.org/funding/lecture-travel-and-childcare-grants/women-in-science-lectures/
Want to understand complex intrinsic and extrinsic metabolic regulation of HSCs? Our latest @natcellbio.nature.com review, led by @aysegulerdemm.bsky.social, synthesize insights into cell fate decisions and highlight implications for leukemogenesis. @nickvangastel.bsky.social rdcu.be/e3smG
Happy to share our latest work on the epigenetic basis of trained immunity in hematopoietic stem cells! @bcmhouston.bsky.social @texaschildrens.bsky.social
For decades, memory-like responses in immune cells have remained unexplained @thekinglab.bsky.social & team reveal epigenetic changes in hematopoietic stem & progenitor cells in a mycobacterial infection model that are retained in downstream macrophages: doi.org/10.1172/jci....
TODAY at #ASH2025 New Frontiers in Neutrophil Biology. W311 at 4pm. Ostuni, Bonnet, Findlay. See you there!! @welner.bsky.social @leegrimeslab.bsky.social
What an awesome stem cell session speaker group for #ASH25 Workshop on Myeloid Development @vangalenlab.bsky.social @thekinglab.bsky.social @paralkarlab.bsky.social Sandra Pinho and Allison Yeh (love the photobomb!)
ASH is coming! Excited to present alongside Vikram Paralkar, Sandra Pinho, Peter Van Galen, and Alison Yeh at the stem cell session of the myeloid workshop on Friday. @ericpietras.bsky.social will be moderating— don’t miss it!
Wow! My student Arushana Maknojia was awarded the Deborah K. Martin Award for best graduate student at BCM! So proud!
Lab Halloween 2025 is in the books— can you guess our theme?
For my lab lead friends, check out this article of best practices from my colleagues and I on the ISEH Junior PI committee on organizing a leading your team. authors.elsevier.com/c/1lxZ~,6sio...
authors.elsevier.com
Jak stat jak stat fun to have @mpndoc.bsky.social in town for a seminar! Thanks for inflammatory insights and inspiration to cure patients!
Congrats to Nicole Wang and Jennifer Deger on their beautiful thesis defenses today in the MSTP October double header! So proud of you both! @bcmfromthelabs.bsky.social
I am so grateful to be able to spend time with colleagues at #iseh2025. Fantastic science and community.
Ready for #ISEH2025 Scientific Session? After 1.5 days of rich, productive discussions, @isehsociety.bsky.social leadership & Board of Directors are all set—with the full program and even the social events lined up! @thekinglab.bsky.social @smckinneyfreeman.bsky.social @nickvangastel.bsky.social
Central trained immunity is still a nascent field— is there true reprogramming of hematopoietic progenitors to influence innate immunity, or is this selection for lineage biased cells? We explore the nuances in this new review. doi.org/10.7554/eLif... awesome collab with Eva Kaufmann and team!
Hematopoietic stem and progenitor cells as a reservoir for trained immunity
Inflammation supports selection, differentiation bias, and epigenetic reprogramming of hematopoietic stem and progenitor cells to generate innate immune memory.
doi.org
Less than a month until ISEH @isehsociety.bsky.social annual meeting in Kumamoto! Bringing some new science to share and excited to see friends and try the food!
It’s just a noncompeting renewal, but I’ve never been so happy.
And here it is! Our study in clonal hematopoiesis and Alzheimer’s disease — product of 5 years’ gestation. urldefense.proofpoint.com/v2/url?u=htt...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
urldefense.proofpoint.com
We had not one but TWO bottles of bubbly to celebrate paper acceptances in the lab!! Exciting stories forthcoming which I am excited to introduce when they’re online!