Katherine King MD PhD

@thekinglab.bsky.social

Professor in Pediatric Infectious Disease researching effects of infection, inflammation, and the microbiome on hematopoietic stem cells and their progeny. How do infections affect bone marrow and vice versa? Co-Director of BCM MSTP. 🌈

Happy to share our latest work on the epigenetic basis of trained immunity in hematopoietic stem cells! @bcmhouston.bsky.social @texaschildrens.bsky.social

JCI insight@insight.jci.org · 6mo ago

For decades, memory-like responses in immune cells have remained unexplained @thekinglab.bsky.social & team reveal epigenetic changes in hematopoietic stem & progenitor cells in a mycobacterial infection model that are retained in downstream macrophages: doi.org/10.1172/jci....

I am so grateful to be able to spend time with colleagues at #iseh2025. Fantastic science and community.

Keisuke Ito@keisukeito-lab.bsky.social · 11mo ago

Ready for #ISEH2025 Scientific Session? After 1.5 days of rich, productive discussions, @isehsociety.bsky.social leadership & Board of Directors are all set—with the full program and even the social events lined up! @thekinglab.bsky.social @smckinneyfreeman.bsky.social @nickvangastel.bsky.social

Central trained immunity is still a nascent field— is there true reprogramming of hematopoietic progenitors to influence innate immunity, or is this selection for lineage biased cells? We explore the nuances in this new review. doi.org/10.7554/eLif... awesome collab with Eva Kaufmann and team!

Hematopoietic stem and progenitor cells as a reservoir for trained immunity

Inflammation supports selection, differentiation bias, and epigenetic reprogramming of hematopoietic stem and progenitor cells to generate innate immune memory.

doi.org