Reduction of primary tumor growth and metastasis in models of triple-negative breast cancer following tilorone administration via type I interferon signaling - Breast Cancer Research

Background People with triple-negative breast cancer (TNBC) typically have poorer survival than those with other breast cancer subtypes, with fewer treatment options available. Type I interferon (IFN)...

link.springer.com

Striking the right balance with type I interferon signalling in cancer

Nature Reviews Cancer, Published online: 23 March 2026; doi:10.1038/s41568-026-00915-1Type I interferons (IFNs) critically influence cancer development, progression and therapeutic response. In this Review, Parker, Haynes and colleagues explore the complexity of IFN signalling, with a particular focus on tumour-intrinsic mechanisms, and outline strategies for reprogramming IFN activity in tumours to enhance anticancer immunity and improve patient outcomes.

dlvr.it

Striking the right balance with type I interferon signalling in cancer - Nature Reviews Cancer

Type I interferons (IFNs) critically influence cancer development, progression and therapeutic response. In this Review, Parker, Haynes and colleagues explore the complexity of IFN signalling, with a ...

nature.com

https://www.nature.com/articles/s41568-026-00915-1

t.co

The hallmarks of cancer immune evasion

Cancer cells often evade the host immune system, challenging the effectiveness of immunotherapy. In this comprehensive review, Galassi et al. summarize key mechanisms of immune evasion within the “thr...

cell.com

A STAT3–STING–IFN axis controls the metastatic spread of small cell lung cancer - Nature Immunology

Here, the authors show that signal transducer and activator of transcription 3 (STAT3) has dual functions in small cell lung cancer as its deletion inhibited primary tumor growth but boosted metastati...

nature.com

The complexity of immune evasion mechanisms throughout the metastatic cascade - Nature Immunology

This Review on the interplay between the immune system and metastasis is part of our wider Series of Reviews on Cancer Immunology and Immunotherapy.

nature.com