Lithocholic acid induces T3SS-dependent formation of invasion-competent Shigella flexneri aggregates | Infection and Immunity

Shigella spp. are the causative agents of bacillary dysentery, or shigellosis, a highly contagious diarrheal disease characterized by abdominal cramps, fever, severe diarrhea, and stools containing mu...

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Proteoglycofili are glycosaminoglycan-containing fibrillar components released by neutrophils to neutralize bacteria

Alternative to the formation of NETs, André et al. describe here that viable neutrophils may release a fibrillar component named proteoglycofili or PGF upon stimulation. PGF formation is associated wi...

cell.com

Activation of the Yersinia type III secretion system induces large-scale spatial reorganization of chromosomal and virulence plasmid DNA

Activation of the Yersinia type III secretion system triggers rapid, large-scale relocalization of both chromosomal and plasmid DNA. This spatial reorganization links secretion activity to growth inhi...

cell.com

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature

The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...

nature.com

Multilevel regulation of c-di-GMP biosynthesis by cAMP signaling increases Shigella sonnei fitness and pathogenicity in response to bile salts

It was previously demonstrated that intestinal pathogens have evolved different mechanisms to enhance their infection and colonization in the intestin…

sciencedirect.com

Neutralizing antibodies induced by IpaB and IpaC mRNA vaccines inhibit Shigella flexneri invasion | Microbiology Spectrum

This study aimed to utilize mRNA vaccine technology targeting conserved antigens (IpaB and IpaC) to overcome the limitations of previous Shigella vaccines. By demonstrating functional immune responses...

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Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ

Eislmayr et al. reveal a previously unrecognized role of macrophages in controlling the intracellular pathogen Shigella. By sensing bacteria and triggering IFN-γ production, macrophages, not neutrophi...

cell.com

Targeting deubiquitinating enzymes and ubiquitin pathway modulators to enhance host defense against bacterial infections | mBio

Antibiotic-resistant infections, particularly those caused by intracellular pathogens, represent an urgent public health threat due to their ability to evade immune responses and resist conventional a...

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Role of listeriolysin O and phospholipases C in L. monocytogenes intercellular protrusion dynamics, resolution, and autophagy avoidance | mBio

Intracellular bacterial pathogens, including L. monocytogenes, spread from cell to cell to effectively disseminate within host tissues and cause systemic infections. We developed a fluorescence micros...

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Host glutathione is required for Rickettsia parkeri cell division and intracellular survival - Nature Communications

Rickettsia species are bacterial pathogens that obligately reside in the host cell cytosol. Here, Sun et al. report that Rickettsia use host glutathione as a nutrient source that enables bacterial cel...

nature.com

Shigella, the first international meeting

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NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD

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VopX, a novel Vibrio cholerae T3SS effector, modulates host actin dynamics | mBio

Despite different infection strategies, enteric pathogens commonly employ a T3SS to colonize the human host and cause disease. Effector proteins are unique to each T3SS-encoding bacterial species and ...

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Klebsiella pneumoniae employs a type VI secretion system to overcome microbiota-mediated colonization resistance - Nature Communications

Through metagenomics, Bray et al. identified Klebsiella pneumoniae interacting microbiota partners in the gut, and a transposon mutagenesis screen revealed a role for its T6SS in gut colonization, wit...

nature.com

ERK activation waves coordinate mechanical cell competition leading to collective elimination via extrusion of bacterially infected cells

Epithelial cells respond to infection with the intracellular bacterial pathogen Listeria monocytogenes by altering their mechanics to promote collecti…

sciencedirect.com

Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation - Nature Microbiology

Peptidoglycan released by neighbouring kin or non-kin cell lysis induces physiological changes that protect from a range of stresses, including phage predation.

nature.com

Characterization of Shigella flexneri serotype 6 strains from geographically diverse low- and middle-income countries | mBio

Shigellosis is an ongoing global public health crisis with >270 million annual episodes among all age groups; however, the greatest disease burden is among children in low- and middle-income countr...

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A temporary cholesterol-rich diet and bacterial extracellular matrix factors favor Salmonella spp. biofilm formation in the cecum | mBio

Typhoid fever is a systemic infectious disease triggered by the gastrointestinal dissemination of Salmonella Typhi and Paratyphi in humans. Three to five percent of infected individuals become chronic...

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A conserved interaction between the effector Sca4 and host clathrin suggests additional contributions for Sca4 during rickettsial infection | Infection and Immunity

Intracellular bacterial pathogens must adapt to a host cell environment to enable their growth, survival, and dissemination. Consequently, they have evolved various mechanisms to manipulate their host environments to create a more hospitable niche (1–5). One common way for pathogens to interact with host cells is through surface-associated and secreted effector proteins. Bacterial pathogen effectors are known to exert diverse functions, including inducing cellular invasion, establishing vacuolar compartments, remodeling host organelles, modifying the host immune response, and facilitating the spread of these pathogens between cells (6–11).

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Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation | mBio

Inflammasomes are essential for host defense against intracellular bacterial pathogens like Legionella, as they activate caspases, which promote cytokine release and cell death to control infection. I...

doi.org

Making contact away from home: a bacterial secreted effector mediates inter-organelle communication | EMBO reports

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

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MAMPM

February 2-4, 2025 Wintergreen Resort, Virginia

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