𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n

Repair of DNA double-strand breaks leaves heritable impairment to genome function

Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...

tinyurl.com

The Nuvvuagittuq Greenstone Belt— a complex geological sequence in northeastern Canada—harbors surviving fragments of Earth’s oldest crust, dating back to ~4.16 billion years old, according to a new Science study. Learn more: scim.ag/3FXN8sq

Evidence for Hadean mafic intrusions in the Nuvvuagittuq Greenstone Belt, Canada

Many questions remain regarding Earth’s earliest crust owing to the rarity of Hadean (>4.03 billion-year-old) rocks and minerals. The Nuvvuagittuq Greenstone Belt (NGB) in Canada may be the only known...

scim.ag

Targeted p63 isoform switch corrects dominant mutations in AEC syndrome without disrupting epidermal homeostasis https://www.biorxiv.org/content/10.1101/2025.06.24.661308v1

Please join us for our 2025 mini-symposium on translational biomarkers and clinical prediction. www.qmul.ac.uk/bcsc/events/...

#InTheNews: Read in @reuters.com about how high UK visa fees for scientists are impacting our research institutes and our mission to beat cancer 👇 www.reuters.com/world/uk/hig...

High UK visa costs deter international scientists and engineers

It took Ed Roberts over a year to find a senior scientist to work at his cancer research laboratory in Scotland, a delay he blames on high UK visa costs that made it harder to attract international workers.

reuters.com

#LocationLocationLocation! Wang Eisenstein Waizman @yaleschoolofmed.bsky.social &co show @ Science Immunology that physical, chemical, & radiation skin damage induces IL33 activating ILC2 & transferring to distal barrier tissues the capacity to induce antibodies causing #allergic responses!

Skin damage signals mediate allergic sensitization to spatially unlinked antigen

Skin injury releases damage-encoded systemic signals that can initiate immunity to novel antigens introduced at distal barrier sites.

science.org

We polled Nature readers to ask if they were thinking of leaving the US for jobs abroad. Three-quarters of them (who said they were US-based scientists) said yes. 🧪 www.nature.com/articles/d41...

75% of US scientists who answered Nature poll consider leaving

More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.

nature.com

Celebrating 20 Years of the International Pachyonychia Congenita Consortium. Read Coulombe et al's News & Perspective Commentary in the April issue. doi.org/10.1016/j.ji... #DermatologyJournal #dermatology #dermsky #dermatologists #dermresearch #dermscience #dermatologyresearch

Nature research paper: Matrix-producing neutrophils populate and shield the skin https://go.nature.com/4iJSgy5

Matrix-producing neutrophils populate and shield the skin - Nature

A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of pathogens.

go.nature.com

📢 Calling all undergraduates looking for hands-on academic research experience! There’s still time to apply for the LMB’s Student Placement Scheme. Visit our website to learn more and get your applications in by 30th March. www2.mrc-lmb.cam.ac.uk/students/stu...

A big thank you to Carsten Gram Hansen and @edinburgh-uni.bsky.social, Institute for Regeneration and Repair for hosting me. Really enjoyed my stay and learning all about the fantastic research in the Centre for Inflammation Research.

A peptic ulcer is a break in the lining of the lower esophagus, stomach, or upper small intestine. This JAMA Patient Page describes peptic ulcers and their causes, signs and symptoms, diagnosis, and treatment options. https://ja.ma/4bzikcU

Wrestling with the RAS cancer drug pipeline tinyurl.com/54faf7kv Alice Shaw of the Dana-Farber Cancer Institute discusses the newly launched Center for RAS Therapeutics and the key role of combination strategies in building on the initial breakthroughs with RAS inhibitors @danafarber.bsky.social

NIH officials were told this morning that approximately 1,000 more grants would be targeted for termination www.theatlantic.com/health/archi...

A Decade of Cuts in a Matter of Days

The Trump administration’s rapid terminations of NIH grants is its most aggressive attempt yet to control American science.

theatlantic.com

🚨This week, many Columbia scientists lost grants that funded over half their annual income. Others will no longer be able to do research that helps treat thousands of sick patients across the US. "It hurts," they told me. My story for @nature.com 🧪 www.nature.com/articles/d41...

‘My career is over’: Columbia University scientists hit hard by Trump team’s cuts

The US government has begun slashing US$400 million in research grants at Columbia University over pro-Palestinian campus protests.

nature.com

It is shocking and saddening to see how the two former global science powerhouses, USA and UK are collapsing in front of our eyes. For different reasons, but ultimately it’s about politics in both cases.

Happy #InternationalWomensDay2025 from a PI with an all-female team of fantastic scientists 🇫🇷🇸🇦🇮🇹🇬🇷

The brain of a man who died nearly 2000 years ago was turned to glass by extreme conditions during the eruption of Mount Vesuvius. Researchers believe a super-heated ash cloud triggered the transformation. https://go.nature.com/3Dd0XBM Watch the video: https://go.nature.com/3Dt4pIt 🧪 🏺

Vesuvius volcano turned this brain to glass

The brain of a man who died nearly 2000 years ago was turned to glass by extreme conditions during the eruption of Mount Vesuvius. Researchers studied the strange material found in the man’s skull and spine and deduced the presence of a super-heated ash cloud that would have caused the tissue to first liquify then rapidly cool into glass - a unique event that has even preserved some brain structures. Read the paper here: https://go.nature.com/4bnpr81 For more stories like these sign up for the Nature Briefing: An essential round-up of science news, opinion and analysis, free in your inbox every weekday: https://go.nature.com/371OcVF

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GIVE THEM TRUNKS YOU COWARDS www.theguardian.com/science/2025...

Scientists aiming to bring back woolly mammoth create woolly mice

Genetically modified mice have traits geared towards cold tolerance, in step towards modifying elephants

theguardian.com

I’ve been yearning to put in this out of office reply 😎

We at Nature denounce this assault on science 🧪 www.nature.com/articles/d41...

Trump 2.0: an assault on science anywhere is an assault on science everywhere

US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

nature.com

QWENDY: Gene Regulatory Network Inference Enhanced by Large Language Model and Transformer https://www.biorxiv.org/content/10.1101/2025.02.22.639640v1

Implantation of engineered adipocytes suppresses tumor progression in cancer models - @nadavahituv.bsky.social go.nature.com/4gqhxvw

Implantation of engineered adipocytes suppresses tumor progression in cancer models - Nature Biotechnology

Adipose manipulation transplantation can reduce tumor growth and proliferation in vitro and in mouse models.

go.nature.com

Postdocs and PhD students - the future of the US research - hit hard by Trump’s crackdown on science 🧪 #academicSky #ECRs @nature.com www.nature.com/articles/d41...

Postdocs and PhD students hit hard by Trump’s crackdown on science

As US federal grants remain frozen and budget cuts loom, anxiety and fear grip early-career researchers.

nature.com

Are PhDs losing their lustre? Why fewer students are enrolling in doctoral degrees www.nature.com/articles/d41...

Are PhDs losing their lustre? Why fewer students are enrolling in doctoral degrees

High living costs paired with stagnant stipends are being blamed for a drop in PhD enrolments in several countries.

nature.com

Join the Molecular Drug Targeting Lab at the University of Vienna! I have a vacant postdoc position for a qualified candidate: either with a background in delivery technologies or immunology. jobs.univie.ac.at/job/Universi...

Science can be so much fun: trying to deposit a massive proteomics data set on PRIDE. Upload tool is JAVA-based (eye roll), and University does not allow JAVA install on IT managed device…

Thanks a lot for having me @nucancer.bsky.social. I had a great time! Really enjoyed learning about all the exciting cancer research happening in this Northern powerhouse!

Ute Jungwirth@utejungwirth.bsky.social · last yr.

Thanks to @walkolab.bsky.social for visiting @newcastleuni.bsky.social and sharing their insights into the interactome of YAP/TAZ.

Sorry to hear this about @cardiffuni.bsky.social Losing 400 faculty means Cardiff Uni is now mostly employing administrators (they currently have 3660 admin to 3410) academics according to their website). At what point do you stop being an academic institution? www.theguardian.com/education/20...

Cardiff University to cut 400 staff and drop subjects including nursing and music

Union describe reductions as ‘cruel’ as university says it will run out of money without changes

theguardian.com

We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below. Please spread the word.