Jon Humphries
@jdhl18.bsky.social
Cell Biologist. Manchester Metropolitan University. Cell-ECM adhesion and proteomics, often in the context of cancer. Google Scholar: https://scholar.google.com/citations?user=h9DWslsAAAAJ&hl=en Orcid: https://orcid.org/0000-0002-8953-7079
"Our real duty as teachers has always been challenging students to think. The task now is finding ways to engage them in the painful, essential work of critical thinking in a world where machines are willing to do it for them." #ScienceWorkingLife https://scim.ag/4vKqh8k
This paper is worth it for table 1 alone. 👏 @sabinehoffmann11.bsky.social @boulesteixlaure.bsky.social et al onlinelibrary.wiley.com/doi/10.1002/...
When to Adjust for Multiple Testing: A Unifying Guiding Principle
Most original articles published in the medical literature report the results of multiple statistical tests. In a few simple cases, there is agreement on whether to adjust for the number of performed...
onlinelibrary.wiley.com
Paying peer reviewers Interview with @danielgorelick.bsky.social about @biologyopen.bsky.social Fast & Fair trial in which peer reviewers were paid £220/review Spoiler: it works - fast, high quality reviews www.nature.com/articles/d41...
Why paying peer reviewers works, according to a journal’s editor-in-chief
A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.
nature.com
Our new preprint 'NucleiSky enables cross-scale multimodal registration of microscopy data using nuclei constellations' is out! 🎉Check out @guijacquemet.bsky.social post first to learn more🤩 In this 🧵 I’ll share how we used NucleiSky in smart microscopy and how you can install and try it yourself 👇
Guillaume Jacquemet@guijacquemet.bsky.social · last mo.Delighted to share our latest preprint "NucleiSky enables cross-scale multimodal registration of microscopy data using nuclei constellations" www.biorxiv.org/content/10.6... Code and App: github.com/CellMigratio...
ICYMI: New online! Actin cytoskeletal dynamics in hepatic myofibroblasts and fibrosis
Actin cytoskeletal dynamics in hepatic myofibroblasts and fibrosis
Nature Reviews Gastroenterology & Hepatology, Published online: 29 June 2026; doi:10.1038/s41575-026-01223-7Liver fibrosis drives chronic liver disease and liver cancer. This Review dissects how actin cytoskeleton dynamics and related pathways govern hepatic stellate activation and fibrogenesis with implications for targeted therapy.
dlvr.it
🧬 Figure Friday What role does magnesium play in important cancer proteins? Thomas E. Wales and colleagues show that Mg²⁺ acts as a structural gatekeeper for KRAS, helping control its shape and activity while revealing new opportunities for drug development. #FigureFriday #ProteinScience #KRAS
@odedrechavi.bsky.social hi I tried the Q.E.D tool and found the results interesting and informative. However, if I got this right it only highlights weaknesses? I think it would also be useful to annotate strengths? I may well have missed this though.
for example i have identified a preprint that isn't found using .com but is using .co.uk Any ideas? I'm logged into both with the same account #googlescholar
Jon Humphries@jdhl18.bsky.social · last mo.Any one else noticing that Google Scholar doesn't work as well as it used to? I've noticed that it doesn't find articles as quickly as it used to i.e. papers can now be in pubmed before scholar. I also wonder if there is a difference between scholar.google.co.uk and scholar.google.com
Any one else noticing that Google Scholar doesn't work as well as it used to? I've noticed that it doesn't find articles as quickly as it used to i.e. papers can now be in pubmed before scholar. I also wonder if there is a difference between scholar.google.co.uk and scholar.google.com
Google Scholar
Google Scholar provides a simple way to broadly search for scholarly literature. Search across a wide variety of disciplines and sources: articles, theses, books, abstracts and court opinions.
scholar.google.co.uk
"the first validated, large-scale framework for judging the quality of life science papers independently of venue, identity, and prestige...Blinded domain-expert professors sided with score three times more often than with journal rank" the-one-percent.qedscience.com 1/n
QED — The most compelling preprints of 2025
the-one-percent.qedscience.com
Of particular interest (I thought) was the fact that oscillatory and elevated shear stress have distinct impacts on production of alternative RNA isoforms - including those coding for the integrin adhesome proteins PDLIM5 and SORBS3 (vinexin) [see figure 4]
Jon Humphries@jdhl18.bsky.social · last mo.Multiomic Reference Map of Endothelial Mechanosensitive Pathways Under Athero- and Erosion-Prone Flow www.ahajournals.org/doi/10.1161/...
Congrats and thanks to Steve White and everyone @martinhumphries.bsky.social who contributed to this work. Really pleased to have been able to make a contribution.
Jon Humphries@jdhl18.bsky.social · last mo.Multiomic Reference Map of Endothelial Mechanosensitive Pathways Under Athero- and Erosion-Prone Flow www.ahajournals.org/doi/10.1161/...
Multiomic Reference Map of Endothelial Mechanosensitive Pathways Under Athero- and Erosion-Prone Flow www.ahajournals.org/doi/10.1161/...
Multiomic Reference Map of Endothelial Mechanosensitive Pathways Under Athero‐ and Erosion‐Prone Flow | Journal of the American Heart Association
ahajournals.org
Inactive β1-integrin acts as a junctional scaffold for angiopoietin/TIE2/FOXO1 signaling www.jci.org/articles/vie...
JCI - Inactive β1-integrin acts as a junctional scaffold for angiopoietin/TIE2/FOXO1 signaling
jci.org
Fibrillin-1 inhibits early adipogenic commitment via αvβ3 integrin signaling www.sciencedirect.com/science/arti...
Fibrillin-1 inhibits early adipogenic commitment via αvβ3 integrin signaling
Extracellular fibrillin-1 is present in many tissues, including adipose tissue. Mutations in fibrillin-1 cause Marfan syndrome, paradoxically presenti…
sciencedirect.com
Diffusing caveolin-1 scaffolds regulate mechanosignalling www.nature.com/articles/s41...
Diffusing caveolin-1 scaffolds regulate mechanosignalling - Nature Cell Biology
Mani, Tardif, Rossier et al. show that mechanical stress triggers caveolin-1 release from caveolae, enabling its diffusion in the plasma membrane and interaction with signalling effectors to regulate ...
nature.com
www.nature.com/articles/s41...
Spatial distribution of the proteome in the human body and in cancers - Nature
A spatially resolved map of the human proteome across a variety of healthy tissues and cancers provides wide-ranging insights in developmental biology and oncology, and could aid the identification of...
nature.com
Wonderful news! #VaccinesWork Cervical cancer deaths fall to zero in young women given vaccine www.bbc.co.uk/news/article...
Cervical cancer deaths fall to zero in young women given vaccine
A new study finds that hundreds of lives have been saved since school-age girls were offered the HPV jab in 2008.
bbc.co.uk
How do donated tissue samples help shape future cancer treatments? Our latest blog explores the work of the MCRC Biobank, which has collected more than 230,000 samples from nearly 30,000 patients to support cutting-edge cancer research. Read more: https://ow.ly/ozuS50Z5EsS
The MCRC Biobank: Turning Tissue Donations into Tomorrow's Treatments - Manchester Cancer Research Centre
Every year, thousands of cancer patients treated at The Christie NHS Foundation Trust, Manchester University NHS Foundation Trust and Northern Care Alliance NHS Foundation Trust choose to donate tissue samples to the Manchester Cancer Research Centre Biobank.
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There's probably never been a better time to remind you that when David Hockney first took his Mum to California she remarked 'all this lovely weather and nobody puts their washing out'.
Dynamic Time-Resolved Remodeling of the Immune Microenvironment After Resistance to BRAF/MEK Inhibitors in Melanoma: Mechanisms, Biomarkers, and Emerging Therapeutic Strategies www.mdpi.com/1422-0067/27...
mdpi.com
Mechanobiology of cancer-associated thrombosis: from molecular mechanisms to therapeutic innovation link.springer.com/article/10.1...
Mechanobiology of cancer-associated thrombosis: from molecular mechanisms to therapeutic innovation - Journal of Nanobiotechnology
Cancer-associated thrombosis (CAT) is the second leading cause of death in cancer patients, with venous thromboembolism affecting 20–30% of cases. While conventional models emphasize biochemical media...
link.springer.com
Pan-cancer atlas of ITGA6 unveils its multifaceted oncogenic roles and therapeutic potential in uveal melanoma link.springer.com/article/10.1...
Pan-cancer atlas of ITGA6 unveils its multifaceted oncogenic roles and therapeutic potential in uveal melanoma - BMC Cancer
Background Integrin alpha 6 (ITGA6) has been implicated in tumorigenesis and progression, but its roles across cancer types and its functional significance in uveal melanoma (UVM) remain incompletely ...
link.springer.com
www.biorxiv.org/content/10.6...
Optimization of stapled peptide inhibitors reveals design principles for targeting talin-induced integrin activation
Talin-induced integrin activation is a central regulator of cell adhesion and signaling. Intracellular Targeting of this pathway remains to be challenging. Here, we report the structure-guided develop...
biorxiv.org
TurboID-Based Proximity Labeling Map Reveals the Protein Interaction Network and Anti-Viral Mechanism Against Influenza A H1N1 faseb.onlinelibrary.wiley.com/doi/10.1096/...
TurboID‐Based Proximity Labeling Map Reveals the Protein Interaction Network and Anti‐Viral Mechanism Against Influenza A H1N1
This integrated schematic depicts H1N1’s tripartite interplay with host defenses: viral HA and PA bind MAVS to suppress TBK1/STAT signaling and IFN-β production, while ITGA2 is co-opted by HA to medi...
faseb.onlinelibrary.wiley.com
Adhesion-derived condensates control component availability to regulate adhesion dynamics www.nature.com/articles/s41...
Adhesion-derived condensates control component availability to regulate adhesion dynamics - Nature Communications
Integrin adhesions allow dynamic cell-matrix interactions to regulate cell behaviour. Here, the authors reveal that tensin 1, a multidomain adaptor protein, forms condensates in cells that act as reve...
nature.com
🔬 Exciting progress in melanoma research. Researchers have announced promising long-term results from a study investigating a personalised mRNA cancer vaccine for people with high-risk melanoma. (1/5)
Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?
In their Cell Science at a Glance article, @zeinabrekad.bsky.social Stavroula Mili, Ellen Van Obberghen-Schilling & Delphine Ciais highlight the ways in which RBPs & local RNA regulation impact adhesion-dependent processes, & the effect of their dysregulation. journals.biologists.com/jcs/article/...
Anticancer activity of RAS-GTP inhibition in cholangiocarcinoma
Anticancer activity of RAS-GTP inhibition in cholangiocarcinoma
Entrialgo-Cadierno et al. demonstrate the potent efficacy of RAS(ON) multi-selective inhibitors in KRAS mutant cholangiocarcinoma and delineate a molecular landscape of resistance driven by oncogenic flux. The study provides a robust translational roadmap for implementing RAS(ON) multi-selective inhibitors as either monotherapies or backbones for combination regimens, potentially redefining the therapeutic paradigm for this recalcitrant malignancy.
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