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Werner Ouwendijk

@wernerouwendijk.bsky.social

Assistant Professor @ dept. ViroScience, Erasmus MC Herpesviruses and neurodegenerative diseases

8 Posts56 Follower59 Folgt
Nature Reviews Microbiology@natrevmicro.nature.com · 5mo ago

ICYMI: New online! Varicella zoster virus and the central nervous system

Varicella zoster virus and the central nervous system

Nature Reviews Microbiology, Published online: 24 February 2026; doi:10.1038/s41579-026-01289-9Varicella zoster virus (VZV) infection causes varicella and herpes zoster and, rarely, severe central nervous system (CNS) complications, including encephalitis. Ogunjimi et al. review the evidence linking herpes zoster with stroke and dementia, summarize innate and adaptive immune responses to VZV-related CNS disease, and debate the consequences of vaccination.

dlvr.it

Nature Communications@natcomms.nature.com · 7mo ago

#Virology Herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to escape the nucleus by tapping into an ancient membrane fusion process

ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes - Nature Communications

Herpesvirales utilize a unique nuclear egress route for capsid export. Here the authors show that herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to facilitate membrane fusion and egress from the nucleus.

dlvr.it

eLife@elife.bsky.social · 9mo ago

Evidence from 14 research funding programmes confirms that early winners tend to keep winning (Matthew effect). But the idea that an early setback makes you stronger later doesn’t replicate widely. buff.ly/UEtcRd4

eLife Assessment This important study reports the results of efforts to replicate two phenomena of significant interest to early-career scientists and scientific policymakers: the Matthew effect and the early-career setback effect. Several previous studies of these effects have focused on early-career researchers with grant proposals that fell just below or just above a funding threshold. Those just above the threshold were more likely to be successful when they applied for funding later in the career (an example of the well-known Matthew effect), while those just below were more likely to go on to have stronger publication records (the early-career setback effect). In this study the Matthew effect was found to be robust across funders, and to generalize from those close to the funding threshold to the whole population. The early-career setback effect was not robust across funders and did not generalize to the whole population. The evidence reported is convincing.
Werner Ouwendijk@wernerouwendijk.bsky.social · last yr.

This is a very exciting study, which suggests that shingles vaccination protects against developing dementia. What could be the underlying mechanisms? Something that we should investigate! www.nature.com/articles/s41...

A natural experiment on the effect of herpes zoster vaccination on dementia - Nature

Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...

nature.com

WHO@who.int · last yr.

At least 95% measles vaccine coverage is needed in all communities to prevent #measles and stop outbreaks. The only way to prevent measles? Two doses of measles vaccine. Let’s close the gap and keep measles away!

At least 95% vaccine coverage of 2 doses is needed to stop measles outbreaks.
WHO@who.int · last yr.

The #measles vaccine has saved an estimated 5 lives every second since 2000. 👉Prevent measles by getting vaccinated with two doses of the measles vaccine.

Measles is preventable with just two doses of measles vaccine.
Dan Depledge@dandepledge.bsky.social · last yr.

Our latest preprint is online! In which we take a left turn and dive head first into the biology of the RNA polymerase III transcriptome and epitranscriptome Do you want to know more? A small thread follows👇 www.biorxiv.org/content/10.1...

Defining expansions and perturbations to the RNA polymerase III transcriptome and epitranscriptome by modified direct RNA nanopore sequencing

RNA polymerase III (Pol III) transcribes cytosolic transfer RNAs (tRNAs) and other non-coding RNAs (ncRNAs) essential to cellular function. However, many aspects of Pol III transcription and processin...

biorxiv.org

Viejo-Borbolla Lab@viejoborbolla.bsky.social · last yr.

Happy to share our publication in #PlosPathogens investigating repression of varicella zoster virus in neuron-like cells: journals.plos.org/plospathogen... Thanks to @dandepledge.bsky.social and other colleagues for their contribution!

Repression of varicella zoster virus gene expression during quiescent infection in the absence of detectable histone deposition

Author summary Varicella zoster virus (VZV) establishes latent infection exclusively in human neurons. This phase of infection is characterized by restricted viral gene expression, lack of detectable ...

journals.plos.org

NRC@nrc.nl · last yr.

Anthony Fauci, vijf jaar geleden het gezicht van de Amerikaanse covidbestrijding, wordt nog altijd met de dood bedreigd door complotdenkers. „Ik redde miljoenen levens en word toch als vijand gezien.” https://buff.ly/40Y2Utx

Arts Anthony Fauci: ‘Ik redde miljoenen levens en word toch als vijand gezien’

Anthony Fauci | Arts en immunoloog: Anthony Fauci, vijf jaar geleden het gezicht van de Amerikaanse covidbestrijding, wordt nog altijd met de dood bedreigd door complotdenkers. „Mensen maken op grond…

buff.ly