Single-nucleoid imaging in whole cells defines the dynamics of the mtDNA life cycle www.biorxiv.org/content/10.6...
biorxiv.org
Hansi Weissensteiner
@whansi.bsky.social
Senior Researcher / Mitochondriac @meduniibk.bsky.social We develop and apply methods to study #mitochondria #genomes #mtdna #haplogroups #heteroplasmy in #cancer .e.g. #prostate or #ageing related diseases #ngs #longreads
Cancer mtDNA mutations: metabolic plasticity and therapeutic promise? www.cell.com/trends/molecular-medicine/fulltext/S1471-4914%2826%2900033-X
Cancer mtDNA mutations: metabolic plasticity and therapeutic promise?
Mitochondria, once viewed mainly as cellular powerhouses, are now recognised as key regulators of cancer metabolism, redox balance, and immune interactions. While early models emphasised a switch to a...
cell.com
Emerging mechanisms of genome degradation during the mtDNA life cycle www.nature.com/articles/s41...
Emerging mechanisms of genome degradation during the mtDNA life cycle - Nature Cell Biology
Mitochondrial DNA (mtDNA) is not static but undergoes a regulated ‘life cycle’ that encompasses replication, maintenance, spatial distribution and turnover. Here, we update emerging mtDNA degradative ...
nature.com
Online now: Mitochondrial transfer from immune to tumor cells enables lymph node metastasis
Mitochondrial transfer from immune to tumor cells enables lymph node metastasis
How cancer cells subvert immunity to colonize the lymph node remains unclear. Terasaki et al. uncover that lymph node metastasis may be driven by an immune-to-cancer mitochondria transfer axis that impairs immune function and augments cancer immune evasion programs through type I interferon signaling.
dlvr.it
Faulty mitochondria cause deadly diseases: fixing them is about to get a lot easier. CRISPR-based tools can’t easily access the DNA in these organelles, but researchers are finding other ways in www.nature.com/articles/d41...
Faulty mitochondria cause deadly diseases: fixing them is about to get a lot easier
CRISPR-based tools can’t easily access the DNA in these organelles, but researchers are finding other ways in.
nature.com
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org. rdcu.be/eKKz1 🇨🇦
Structural insights into DdCBE in action enable high-precision mitochondrial DNA editing www.cell.com/molecular-ce...
Structural insights into DdCBE in action enable high-precision mitochondrial DNA editing
Based on cryo-EM structures of functioning DdCBE, Xiang et al. developed a model to guide TALE-recognition region and spacer length design. Application of the model and an engineered editor with a 2–3...
cell.com
Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells www.science.org/doi/full/10....
Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells
Somatic mtDNA mutations undergo positive selection, shaping cell fitness and contributing to functional heterogeneity.
science.org
Nuclear mitochondrial DNA transfer revisited: From genomic noise to hallmark of aging www.sciencedirect.com/science/arti...
Nuclear mitochondrial DNA transfer revisited: From genomic noise to hallmark of aging
Nuclear insertions of mitochondrial DNA (mtDNA) segments (NUMTs) represent an evolutionarily conserved phenomenon originating from the ancient endosym…
sciencedirect.com
Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations | Science www.science.org/doi/10.1126/...
Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations
Somatically acquired mitochondrial DNA mutations accumulate with age, but the mechanisms and consequences are poorly understood. Here we show that transient injuries induce a burst of persistent mtDNA...
science.org
Mitochondria protect against an intracellular pathogen by restricting access to folate www.science.org/doi/10.1126/...
Mitochondria protect against an intracellular pathogen by restricting access to folate
As major consumers of cellular metabolites, mitochondria are poised to compete with invading microbes for the nutrients that they need to grow. Whether cells exploit mitochondrial metabolism to protec...
science.org
“A mitochondrial electron surplus induces sleep” Mitochondrial origins of the pressure to sleep www.nature.com/articles/s41...
Mitochondrial origins of the pressure to sleep - Nature
Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.
nature.com
A big day for preventing mitochondrial diseases from transmitting to the next generation www.nature.com/articles/d41... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10....
Selfish mutations promote age-associated erosion of mtDNA integrity in mammals www.nature.com/articles/s41...
Selfish mutations promote age-associated erosion of mtDNA integrity in mammals - Nature Communications
Mutations in mtDNA contribute to mitochondrial disease and aging only if they rise in abundance. Here, the authors show that deleterious mutations reach high abundance by hitchhiking on genomes that h...
nature.com
Donor genetics and storage conditions influence mitochondrial DNA and extracellular vesicle levels in RBC units insight.jci.org/articles/vie...
JCI Insight - Donor genetics and storage conditions influence mitochondrial DNA and extracellular vesicle levels in RBC units
insight.jci.org
Exciting preprint from @rahulg603.bsky.social and colleagues! Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood www.biorxiv.org/content/10.1...
Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood
One of the strongest signatures of aging is an accumulation of mutant mitochondrial DNA (mtDNA) heteroplasmy. Here we investigate the mechanism underlying this phenomenon by calling mtDNA sequence, ab...
biorxiv.org
Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell great work by Martin Picard www.scientificamerican.com/article/why-...
The Hidden Social Lives of Mitochondria
When these energy-giving organelles thrive, so do we
scientificamerican.com
🥁 NEW: Commentary in @cellcellpress.bsky.social! by @msabrysarhan.bsky.social Giacomo Antonello @whansi.bsky.social @cengoni.bsky.social @dmascalzoni.bsky.social @leviwaldron1.bsky.social Nicola Segata, Christian Fuchsberger www.cell.com/cell/fulltex... 1/4
Human mitochondrial DNA in public metagenomes: Opportunity or privacy threat?
Human DNA is unavoidably present in metagenomic analyses of human microbiomes. While current protocols remove human DNA before submission to public repositories, mitochondrial DNA (mtDNA) has been ove...
cell.com
Exciting news! Our commentary is finally out, cudos to the team at EURAC (BZ) and CIBIO (TN) 👏 Human mitochondrial DNA in public metagenomes: Opportunity or privacy threat? www.cell.com/cell/fulltex...
Human mitochondrial DNA in public metagenomes: Opportunity or privacy threat?
Human DNA is unavoidably present in metagenomic analyses of human microbiomes. While current protocols remove human DNA before submission to public repositories, mitochondrial DNA (mtDNA) has been ove...
cell.com
Mitochondria – the CEO of the cell journals.biologists.com/jcs/article-...
Mitochondria – the CEO of the cell
Summary: In light of research advances recognizing the roles mitochondria play in directing cellular processes and behaviors, we propose reframing mitochondria as the chief executive organelle of the ...
journals.biologists.com
Mitochondrial DNA disease discovery through evaluation of genotype and phenotype data: The Solve-RD experience www.cell.com/ajhg/fulltex...
Mitochondrial DNA disease discovery through evaluation of genotype and phenotype data: The Solve-RD experience
Exome and genome reanalysis from the Solve-RD cohort done with an automated mtDNA-filtering pipeline and MitoPhen-based HPO phenotype similarity scoring uncovered previously undiagnosed mtDNA variants...
cell.com
The brain’s energy landscape as a potential window into brain health www.nature.com/articles/d41... (study led by Martin Picard and Michel Thiebaut de Schotten)
First map of human brain mitochondria is ‘groundbreaking’ achievement
Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.
nature.com
Mitochondrial DNA signals driving immune responses: Why, How, Where? biosignaling.biomedcentral.com/articles/10....
Mitochondrial DNA signals driving immune responses: Why, How, Where? - Cell Communication and Signaling
There has been a recent expansion in our understanding of DNA-sensing mechanisms. Mitochondrial dysfunction, oxidative and proteostatic stresses, instability and impaired disposal of nucleoids cause t...
biosignaling.biomedcentral.com
Mitochondrial transplantation: Triumphs, challenges, and impacts on nuclear genome remodelling www.sciencedirect.com/science/arti...
Mitochondrial transplantation: Triumphs, challenges, and impacts on nuclear genome remodelling
Mitochondria are membrane-bound organelles of eukaryotic cells that play crucial roles in cell functioning and homeostasis, including ATP generation f…
sciencedirect.com
Not really my announcement to make--I am but a lesser co-author--but IQ-TREE 3 has just been released! (Most credit to Minh Bui and @roblanfear.bsky.social and their labs) ecoevorxiv.org/repository/v...
IQ-TREE 3: Phylogenomic Inference Software using Complex Evolutionary Models
ecoevorxiv.org
Cells are swapping their mitochondria. What does this mean for our health? www.nature.com/articles/d41...
Cells are swapping their mitochondria. What does this mean for our health?
Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.
nature.com
Small molecules restore mutant mitochondrial DNA polymerase activity www.nature.com/articles/s41...
Small molecules restore mutant mitochondrial DNA polymerase activity - Nature
An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.
nature.com