@fariatrypslab.bsky.social in a major collaborative effort with researchers from Imperial College, Oxford, Oxford Brookes, and Edinburgh, has identified a novel factor, ESBX, as the key coordinator between the activation and repression of surface antigen genes in trypanosomes.

Great to see York Press spotlight the £2.5m awarded last year to CBR members for blood cancer research - continued recognition of work driving better understanding and future treatments #BloodCancerResearch #CBR #YorkScience #ResearchImpact www.yorkpress.co.uk/news/2582263...

£2.5m boost for University of York to advance pioneering blood cancer research

University of York researchers have received a £2.5 million boost from Cancer Research UK to advance pioneering work into blood cancers.

yorkpress.co.uk

#job Research Technician with Faria & Mottram groups within @biologyatyork.bsky.social @ybri-uoy.bsky.social investigating the interplay between genome organisation, nuclear architecture & gene expression regulation in Leishmania. Apply by: 23/02/2026 jobs.york.ac.uk/vacancy/tech...

We’re hiring a PDRA and a technician! If you’re passionate about #parasites #genomes #condensates then this project is for you! Help us decode the role of nuclear architecture in gene expression regulation in #Leishmania alongside the @mottramlab.bsky.social @york.ac.uk @ybri-uoy.bsky.social

📢 2 funded PhD positions at the University of York IndiBrain MSCA Doctoral Network, ERC-funded Central vision loss: linking neural + psychosocial factors to predict outcomes - with Dr Heidi Baseler & Dr Holly Brown Stereo vision differences + brain connectivity - with Prof Tony Morland

"We think this research is incredibly exciting because it suggests that bladder cancer might be preventable" #openaccess paper in @aaas.org Science Advances - see thread below from @drsimonbaker.bsky.social @biologyatyork.bsky.social @ybri-uoy.bsky.social 🔓 📄

Bladder cancer may be caused by the body’s response to a common virus, new research suggests

Bladder cancer might be caused by our cell’s response to a common virus which infects nearly everyone in childhood, according to new research led by scientists at the University of York.

york.ac.uk

Simon Baker@drsimonbaker.bsky.social · 8mo ago

What causes bladder cancer initiating mutations? Our paper in Science Advances asks the question: can BK virus infections of normal urothelium lead to the APOBEC3 mutational signatures found in bladder cancers? We found that they can!

Delighted to have Prof Jenna Gregory as today's Biomedical Science seminar speaker from @uniofaberdeen.bsky.social Jenna presented her work on improving translation in neurodegenerative diseases Hosted by Prof Stephen Smith

Excited to have Dr Adrian Najer as today's Biomedical Science seminar speaker from @imperialcollegeldn.bsky.social Adrian presented his work on nanomedicines and nanodiagnostics for parasites, viruses, and bacteria Hosted by Dr Stuart Higgins

Exciting news! 🎉 We'd like to welcome Professor Ian Hitchcock as our new Director. With a passion for innovation and collaboration, @ian-hitchcock.bsky.social will lead us into an inspiring new chapter of research excellence

Congrats to @joanarcf.bsky.social @biologyatyork.bsky.social who has been awarded a BBSRC responsive mode grant, with @mottramlab.bsky.social as a co-I & collaborators @ipmontevideo.bsky.social @warwickuni.bsky.social

🚨 We have 3 fully funded PhD studentships open! Join the Grey Lab & collaborators at @biologyatyork.bsky.social, @universityofleeds.bky.social & @ybri-uoy.bsky.social to explore stem cells, proteomics & leukaemia biology 📍Start Oct 2026 | 💡Apply via MRC & BBSRC 👇Details in thread 👇

Thrilled to have @ewanbirney.bsky.social as today's BMS seminar speaker & as a keynote in the @biologyatyork.bsky.social Postdoc Symposium Ewan presented his work on "Genomics, Imaging and AI: three technologies changing research and healthcare" Hosted by Prof Gavin Wright

Discovery Medicine North (DiMeN) PhD projects are now open for applications! Are you looking for exceptional research training and support, access to outstanding facilities and expertise, and enhanced funding and training to support career development and research excellence?

Excited to have @sankarinagarajan.bsky.social @mcf-uom.bsky.social as our Biomedical Science seminar speaker today, hosted by @andrewholding.bsky.social Sankari presented her work on the role of transcription factors in mediating the progression to drug resistance and metastasis in breast cancer

Excited to have @alainkohlvirology.bsky.social as this weeks Biomedical Science seminar speaker, talking about his work on antiviral RNAi in mosquitoes. Hosted by Dr Natalie Prow.

We are delighted that our latest @york.ac.uk & @ybri-uoy.bsky.social work showcasing our photonic biosensor for Alzheimer's disease blood biomarkers has been published in @optica.org! 👇 opg.optica.org/optica/fullt... Thanks to @alzheimerssoc.bsky.social & @alzheimersresearchuk.org for support!

New preprint! 🚨 I'm delighted to share our latest @york.ac.uk & @ybri-uoy.bsky.social pre-print: "Detergent-Triggered Membrane Remodelling Monitored via Intramembrane Fluorescence De-Quenching." Congratulations to Claudia from the team on her first manuscript! 👇👇 www.biorxiv.org/content/10.1...

Detergent-Triggered Membrane Remodelling Monitored via Intramembrane Fluorescence De-Quenching

Detergent-induced membrane solubilization is important for several biotechnological applications including membrane protein isolation, cell lysis and virus inactivation. The thermodynamic details of t...

biorxiv.org

Pleased to have @elkslab.bsky.social kicking off the 2025-26 series of our Biomedical Seminars, hosted by @noemiehamilton.bsky.social Phil presented his work on using zebrafish models to study the roles of HIF in host response to infection

Research conducted by our Director @ian-hitchcock.bsky.social's collaborators in Oxford has found that platelets could help make cancer-detecting blood tests much more effective Read more about the study on ‪@cancerresearchuk.org‬ website news.cancerresearchuk.org/2025/08/14/p...

The "humble" blood cells that could expose cancer's secrets - Cancer Research UK - Cancer News

Our scientists have discovered that platelets are swelling with information which could help us detect cancers earlier.

news.cancerresearchuk.org

We're kicking off the third #NeuroBioUK - an exciting day full of neuronal cell biology ahead! Massive thank for @bscb-official.bsky.social support and a shout out to our industry sponsors!

What’s the difference between female and male Th cells? We have a new paper on this! The mighty Malat1 controls Th2 differentiation in female but not male cells. Work by Mags Gwynne and Katie West ‪@jimmunol.bsky.social‬ doi.org/10.1093/jimm... @york.ac.uk‬, @ybri-uoy.bsky.social‬, ‪@hyms.ac.uk‬

Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL-2

Abstract. Identifying cell intrinsic regulators of immune sexual dimorphism is critical for treatment of several immunopathologies. We show that Malat1 is

doi.org

Delighted with our new paper on a novel itaconate transporter in the human pathogen Pseudomonas aeruginosa, led by Javeria and Reyme. @ybri-uoy.bsky.social @javeriamehboob.bsky.social @bethkw.bsky.social A duplicated transporter on its way to itaconate selectivity portlandpress.com/biochemj/art...

First paper from Orlagh Anderson PhD project is out. She found a chromid is a distinct & unique feature of Clostridium butyricum. More to come on the virulence related genes.. @yorkshirebiodtp.bsky.social @ybri-uoy.bsky.social www.microbiologyresearch.org/content/jour...

Comparative genomics of Clostridium butyricum reveals a conserved genome architecture and novel virulence-related gene clusters

Bacteria from the species Clostridium butyricum encompass a diverse range of phenotypes. While some strains are used as probiotics, others have been isolated from cases of botulism and necrotizing ent...

microbiologyresearch.org

How do parasites strategically organise their genomes to influence gene expression? If you’re curious, check our latest review in @cp-trendsparasitol.bsky.social ! @biologyatyork.bsky.social @ybri-uoy.bsky.social @pasteur.fr www.sciencedirect.com/science/arti...

🚨 New preprint!🚨We introduce a DNA-scaffold strategy for efficient dye labelling of structured RNAs, enabling #smFRET studies of freely-diffusing SARS-CoV-2 pseudoknots🧬 👉 biorxiv.org/content/10.1... #smFRET #RNA #biophysics #SARSCoV2 #singlemolecule #Covid

A DNA scaffold approach facilitates 5′ labelling of the SARS-CoV-2 RNA pseudoknot for smFRET investigation

Single-molecule Förster resonance energy transfer (smFRET) studies of highly structured RNA molecules are often frustrated by issues with efficient dye conjugation. Here, we develop a DNA scaffold-bas...

biorxiv.org

🚨New Preprint! Latest research led by @jemmabetts.bsky.social & @chillzaa.bsky.social reveals the structure of a protein-dependent riboswitch, revealing new mechanistic principles that could inspire novel antivirals! Thanks @ukri.org, @ei-science.bsky.social, @ybri-uoy.bsky.social for support! 🔬

Chris H. Hill@chillzaa.bsky.social · last yr.

New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨ www.biorxiv.org/content/10.1...

Yorkshire Cancer Research hosted the White Rose Cancer Report launch event in Sheffield on 3rd July Yorkshire is one of the regions hardest hit by cancer Karen, David and Geoff shared their positive experiences, and how patient-centric care has literally saved their lives

We have a new 3-year PDRA post in Cancer Immunology. Ideal if you have a background in T cells, ideally human, and are interested in cancer immunology and RNA medicine. It’ll be fun! www.jobs.ac.uk/job/DNV085/r... Funded by ‪@yorkagainstcancer.bsky.social‬ @hyms.ac.uk @ybri-uoy.bsky.social

(1/4) Three new pieces of research have been published from the ProteoStem ( www.proteostem.co.uk ) research group @billgrey.bsky.social working in @biologyatyork.bsky.social @ybri-uoy.bsky.social @cbr-uoy.bsky.social

www.nature.com/articles/s41... Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!

Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes - Nature Communications

Transcription in trypanosomatids, such as Trypanosoma brucei, is predominantly polycistronic and involves unconventional RNA polymerase II promoters. This study uses precision gene editing, site-satur...

nature.com