Zam Kassiri

@zamkassiri.bsky.social

Professor, Cardiac and vascular matrix remodeling. Deputy Editor AJPHeart. U of Alberta, Dept Physiology #ualberta www.kassirilab.com

New in our partnership with @glaucomflecken.bsky.social: the KEYNOTE-905 trial evaluated enfortumab vedotin plus pembrolizumab as perioperative therapy in patients with muscle-invasive bladder cancer who were ineligible to receive cisplatin. Read the full study for free: https://nej.md/DrG40

Mehdi Khalaj and Katie Tolley are the #USask recipients of the 2026-27 Lieutenant Governor Scholarship awards. These prestigious scholarships help ensure the next generation of leaders have the tools to turn innovative ideas into real world impact. news.usask.ca/articles/stu...

USask students receive Lieutenant Governor Scholarship awards - News

Four outstanding Saskatchewan graduate and post graduate students are being recognized for their academic excellence and leadership through the 2026-27 Saskatchewan Lieutenant Governor Scholarship and...

news.usask.ca

Cool paper on why the ❤️ is more resistant to metastasis. Love the first part. Very cool system! The paper steers toward Nesprin and DNA demethylation near the end as an explanation. I'm surprised no data on DNA damage. Also, wonder if tissue density is at play too. www.science.org/doi/10.1126/...

Mechanical load inhibits cancer growth in mouse and human hearts

The heart rarely develops cancer, and, at the same time, it lacks regenerative capacity, as cardiomyocytes stop proliferating after birth. This suggests that mechanisms limiting cardiac regeneration m...

science.org

CLOSURE-AF trial: In patients with atrial fibrillation, catheter-based left atrial appendage closure has been suggested as an alternative to medication for stroke prevention. Research findings comparing these approaches are summarized in a new Quick Take video. nej.md/3O19aya #Cardiology #AFib

A visual representation of the CLOSURE-AF trial, which compared two approaches for patients with atrial fibrillation—catheter-based left atrial appendage closure and medication for stroke prevention.

suppressing fibroblast activity too early after MI -> not good; suppressing myoFB activity after the early pos-MI phase -> Great! And the benefits lasted for 4 weeks (in mice)! Extreme hard work by PhD student, Yingxi Li and great collab with Engineering (L Westover).CVR2026 doi: 10.1093/cvr/cvaf256

Li et al. Cardiovascular Research 2026

doi: 10.1093/cvr/cvaf256

Finally in Publication: knockdown of ADAM17 in smooth muscle cells markedly worsened atherosclerosis (in LDLR-KO mice) even though plasma hyperlipidemia remained unchanged. Arterial cells are critical players in atherosclerosis development. (Atherosclerosis. 2025 doi: 10.1016/j.atherosclerosis)

Meganathan et al. Atherosclerosis. Dec 2025

I swore an oath to the Constitution in 1986. I've upheld it through 25 years of service and every day since I retired. If Trump's trying to intimidate me, it won’t work. I’ve given too much to our country to be silenced by bullies who care more about power than the Constitution.

Bild