The newly redesigned #Matrisome Portal is now live: matrisome.org. Built to meet #ADA standards, the new site improves accessibility, usability, and overall experience for all. Big shout-out to Tali for leading this effort! Take a look and let us know what you think! #Accessibility #ADACompliance

Newly published work from our lab out now #ATVB @ahajournals.bsky.social showing changes in ribosome associated mRNA in chronic conditions of disturbed flow and circulating blood lipids : www.ahajournals.org/doi/10.1161/...

@hhmi-science.bsky.social's #FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits Stable, sustained support can transform your career: Senior Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA

Early Career Faculty Program | Freeman Hrabowski Scholars | HHMI

The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...

bit.ly

We’re hiring! Tenure-track faculty position in cancer research at LSU Health Shreveport (Pathology & Translational Pathobiology). Looking for investigators building programs at the interface of cancer, metabolism, inflammation, and vascular biology. www.lsuhsc.edu/shv/CareerOp...

Very interesting mouse model of preeclampsia - based on maternal, not fetal loss of KLF4 - where hypertension does not develop after gene deletion, but does with pregnancy: www.biorxiv.org/content/10.6...

Today I would like to share a publication that is particularly meaningful to me. Our tribute to my late mentor, Richard Hynes, has just been published in Matrix Biology. I hope you will take a moment to read and celebrate the legacy of an extraordinary scientist and mentor. doi.org/10.1016/j.ma...

Very sad to hear of the passing today of our UCSF colleague Mike Bishop at the age of 90. A legendary and inspiring figure. He also led UCSF as Chancellor. Have a listen to his Nobel lecture. youtube.com/watch?v=CDv7...

Michael Bishop, Nobel Prize in Physiology or Medicine 1989: Official Lecture

YouTube video by Nobel Prize

youtube.com

A mouse model of Nose bleeding #HereditaryHemorrhagicTelangiectasia Bmx+ Endothelial Cell ALK1 KO🐭 +🧠microhemorrhage Arterial tortuosity, ectasia Arteriolar smooth muscle cell wrapping defects ⏬pial/mesenteric arterial tone @mfnavedo.bsky.social #CircRes 2026 www.ahajournals.org/doi/10.1161/...

Considerations in the Use of Mouse Models of Vascular and Valvular Calcification Our new article is now published ⁦‪in ATVB @ahascience.bsky.social www.ahajournals.org/doi/10.1161/...

Considerations in the Use of Mouse Models of Vascular and Valvular Calcification | Arteriosclerosis, Thrombosis, and Vascular Biology

CLINICAL PROBLEM: Vascular and valvular calcification significantly contributes to cardiovascular morbidity, particularly in patients with diabetes, atherosclerosis, advanced age, and chronic kidney d...

ahajournals.org

I had to renegotiate my F99/K00 award twice in 6 months, and on both occasions I asked what specifically “DEI activities” means. I didn’t get clear answers, so I was hopeful the person that directive came from could specify (the NIH Director). I asked the on @whyshoulditrustyou.bsky.social podcast

Excited to share our new preprint showing cGAS mediates innate immune activity in TDP-43 proteinopathy. Pharmacological inhibition of cGAS restores microglial function, corrects RNA mis-splicing, & protects motor neurons across human iPSC & mouse models of ALS www.biorxiv.org/content/10.6...

Upcoming Gordon Research Conference on ENDOTHELIAL CELLS Spain (July 5-10, 2026).The latest breaking topics in vascular biology focused on endothelial cells will be featured. Open slots reserved for oral presentations. Register early to reserve your spot. www.grc.org/endothelial-...

This is perhaps the most tragic of the consequences of the attack by Trump and colleagues on NIH. Gutting the next generation of American science 🧪

Jenna Norton@jenna-m-norton.bsky.social · 6mo ago

Check this out straight from the NIH website, acknowledging that multiyear funding was likely responsible for a 20% decrease in early stage investigators. And that it was expected. A strange approach for someone so committed to the next generation of scientists. grants.nih.gov/news-events/...

We are excited to share a new discovery in heart transplant www.biorxiv.org/cgi/content/..., which shows a critical role for the endothelium in organizing long term immune responses, and cardiac allograft vasculopathy.

It was pleasure to host my former lab mate Noor Jailkhani from Matrisome Bio yesterday at The University of Connecticut School of Medicine. Not many can say that they both developed a new technology hands on, and then led this into the market as the CEO of a successful company.

Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask? rdcu.be/eN1jm

Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer

Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...

rdcu.be

Happy to share an exciting paper from my former lab mate, Jess Hebert, showing Cas12 efficacy and use in somatic screening. Take a look if you are considering the approach! www.nature.com/articles/s41...

Efficient and multiplexed somatic genome editing with Cas12a mice - Nature Biomedical Engineering

Multiplexed editing using Cas12a transgenic mice facilitates the study of disease models with complex genotypes.

nature.com

Despite strong headwinds, we are continuing to do our work. Congratulations to lead author Ashok Cheemala. Here, Ashok shows that even a single point mutation in TDP-43 leads to large defects in cell-cell junction and barrier www.science.org/doi/10.1126/...

Amyotrophic lateral sclerosis and frontotemporal dementia mutation reduces endothelial TDP-43 and causes blood-brain barrier defects

ALS-FTD–associated TDP-43 point mutation in endothelial cells leads to BBB loss and is replicated by gene deletion.

science.org

I'm happy to announce that our paper describing the first in human tissue application of inCITE-seq, to assess nuclear levels of RNA-binding proteins, and key regulators of the blood brain barrier (b-Catenin and NF-kB) is now available online from Nature Neuroscience www.nature.com/articles/s41...

Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration - Nature Neuroscience

Targeting the endothelium across ages and neurodegenerative diseases in 92 donors with single-cell inCITE-seq reveals similar alterations in ~40% of capillaries in AD, ALS and FTD. Endothelial TDP-43 ...

nature.com

www.motherjones.com/politics/202...

NIH is again throttling research funding in defiance of a federal court order

A freeze on "new and continuation awards" will "remain in place" pending DEI review, states a new internal memo.

motherjones.com

www.science.org/doi/10.1126/...

Come together, right now

The chaos, conflicting information, firings, and hurtful rhetoric of the Trump administration’s approach to science over the past month are causing anxiety, grief, and concern for the scientific commu...

science.org

A source close to the situation confirmed that study sections are continuing to be cancelled. On the chopping block this week: developmental brain disorders, mechanisms of cancer therapy, and neurotoxicology of alcohol. For some labs, this was the last chance to get funding or they’ll shut down.

Hannah Harris Green@whatsitlike.me · last yr.

Trump officials are trying to sneak around federal judges’ orders. They could be held in civil contempt of court, which can include jail time and can’t be undone with a presidential pardon, according to @sbagen.bsky.social . My latest for @theguardian.com www.theguardian.com/us-news/2025...

Our latest work on targeting the poison exon in #RNA #splicing factor TRA2B in #cancer reveals a role for this non coding transcript and opportunities for targeting splicing factor levels across multiple tumor types rdcu.be/d90Ra #RNAsky @jacksonlab.bsky.social

Antisense oligonucleotide-mediated TRA2β poison exon inclusion induces the expression of a lncRNA with anti-tumor effects

Nature Communications - The oncogenic splicing factor TRA2β is reported to be upregulated in human cancers partly by increased TRA2β poison exon (PE) skipping. Here the authors show that...

rdcu.be

Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify Sign the Petition: chng.it/kK2HMP5pGk "Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."

Sign the Petition

Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

chng.it

Cool new work from Jenn Prescher and coworkers @ucirvine.bsky.social, “RNA lantern” technology for bioluminescence imaging of RNA transcripts www.nature.com/articles/s41...

A modular platform for bioluminescent RNA tracking - Nature Communications

Studying RNA dynamics in vivo often relies on fluorogenic approaches, but these can be hampered by factors such as limited sensitivity and sample autofluorescence. Here, the authors describe an ultras...

nature.com

Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases www.nature.com/articles/s41...

Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases - Nature Genetics

This analysis of single-cell RNA sequencing data from peripheral blood mononuclear cells for 474 individuals of diverse Asian ancestries in the Asian Immune Diversity Atlas links cell-type-specific sp...

nature.com

Have you wondered if there is a role for the endothelium in regulating immune responses, beyond its function as a gatekeeper? Here, we molecularly define an immune transition of the endothelium required for chronic CD8 T cell responses in atherosclerosis www.biorxiv.org/content/10.1...

Endothelial Immunosuppression in Atherosclerosis : Translational Control by Elavl1/HuR

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

biorxiv.org

www.biorxiv.org/content/10.1... Interesting new work showing vascular cholesterol metabolism as a negative feedback on neurovascular coupling.