Check out our new review in Reproduction! 💥🥚🔬 In “The explosion of life”, @anitabichisecchi.bsky.social, @petramikec.bsky.social and I explore how live imaging has shaped our understanding of ovulation, revealing the cellular and tissue dynamics that drive egg release. doi.org/10.1093/repr...

Interplay Between Protein-RNA Binding and Phase Separation Drives Emergent Behavior in RNP Condensates https://www.biorxiv.org/content/10.64898/2026.06.25.734509v1

Online Now: Translational activation: An unforeseen function of RNP biomolecular condensates Online now:

Translational activation: An unforeseen function of RNP biomolecular condensates

In this perspective, Haidar et al. discuss the emerging function of cytoplasmic RNP condensates in translation. The perspective highlights the dual role of condensates in translational repression and activation and the biophysical properties allowing these two functions. It further proposes future directions for decoding the functional compartmentalization of condensates.

dlvr.it

Getting lost in technical nitpicking was not enough to replicate what the worst human reviewers can do. Happy to announce a decisive further step: QED can now also spit nonsense on manuscript impact

Pedro Beltrao@pedrobeltrao.bsky.social · last mo.

@qedscience.bsky.social has come up with a really controversial idea - an AI score for scientific impact. This trained score correlates with the impact factor of published preprints and the binning of papers into discrete quality bins accessed by independent scientists. Backlash in 3, 2, 1... (more)

Whether condensates have real biological functions has long been debated. Our new Molecular Cell Perspective argues translation is a core one, not just repression. Next: live high-res imaging + probing condensate dynamics should let us get at where translation starts and how condensates shape it.

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

It was a pleasure to help @mariodelr.bsky.social, @henriqueslab.bsky.social and everyone on this new way to think and plan our microscopy experiments!

Mario Del Rosario@mariodelr.bsky.social · 2mo ago

Congratulations to Damián Martinez, Bruno Saraiva, @taylashakespeare.bsky.social, @wmarkbates.bsky.social, Dylan Owen, @christlet.bsky.social and @henriqueslab.bsky.social We hope VLab4Mic helps researchers design better experiments and ask better biological questions 💻 vlab4mic.henriqueslab.org

📚 Textbook rewrite: #Yeast reveals lysosomes get protons directly from mitochondria via membrane contacts, not from cytosol as thought. Aging breaks these contacts, causing de-acidification that disrupts autophagy & cellular function 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵 www.biorxiv.org/content/10.6...

Happy Sunday! It has been another fantastic week for our beloved #oocytes! The streak on CPLs continues with this awesome work from Miguel Leung: pubmed.ncbi.nlm.nih.gov/41986725/! Full issue here: biomed.news/bims-cebooc/... Thanks @biomednews.bsky.social for preselecting.

Happy relaxing Sunday eggficionados! Enjoy the latest papers on oocyte cell biology here: biomed.news/bims-cebooc/... The CPLs are on fire these days, here new insights on their functions: pubmed.ncbi.nlm.nih.gov/41959504/ #cebooc is powered by @biomednews.bsky.social

💥🥚 ANR-funded Assistant Engineer position open in our “Control & Dynamics of the Ovarian Cycle” group at IBDM Marseille 🇫🇷 Work on mouse lines + lab logistics + follicle culture/imaging 🔬 🗓️ Apply by 26 Jan: emploi.cnrs.fr/Offres/CDD/U... Please share widely — especially with colleagues in France!

Periscelis wheeleri, the most grumpy old man fly I've ever seen

Postdoctoral position in the team of Alessandro Barducci in the CBS, focusing on multiscale simulations of RNA-driven condensates, with applications in synthetic biology. More information : www.cbs.cnrs.fr/images/jobs/... The position is expected to start in early 2026, with some flexibility.

Liquid-liquid phase separation of HP1? Not in our mouse fibroblasts… This paper by the Fabian Erdel group offers a fresh perspective on how this can be reconciled with seemingly conflicting reports: The phase separation propensity of HP1 decreases from yeast → fly → mouse. doi.org/10.1038/s414...

Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social‬ @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing. www.biorxiv.org/cgi/content/...

RNA droplets that grow and segregate by ribozyme catalysis. Check out our latest preprint www.biorxiv.org/content/10.1101/2025.08.29.673008v1

Happy to share our community note published in Nature Communications @natcomms.nature.com. In this 14-page article (34 authors from 9 countries), we discuss current practices in phase separation. We hope it will be useful to the biomolecular condensate community. www.nature.com/articles/s41...

What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. www.nature.com/articles/s41... in @nature.com ‬ with @yaotianzhang.bsky.social Denes Hnisz & team.

New method drop: HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale, subcompartmental resolution. Thereby we resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning. www.biorxiv.org/content/10.1...

We are very happy that XiaoYan's (Andy!) paper is out, congratulations to all authors @cellpress.bsky.social @xiaoyan52802927.bsky.social www.cell.com/cell/fulltex... Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD @mpi-cbg.de @biotec-tud.bsky.social

#mRNADecay #Ribosome #Frameshift #Scerevisiae #NMD #CodonOptimality Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay: Molecular Cell www.cell.com/molecular-ce...

Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay

Zhang et al. identify a regulatory mechanism for how cells adapt to nutrient scarcity through widespread −1 ribosomal frameshifts, culminating in accelerated mRNA decay. This process, dependent on cod...

cell.com

1/ Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)

Very excited to have been a part of this great work with @matteomazzocca.bsky.social, Simon Grosse-Holz, @jessematthias.bsky.social, and @andersshansen.bsky.social. Please check it out now! www.biorxiv.org/content/10.1...

Chromatin Dynamics are Highly Subdiffusive Across Seven Orders of Magnitude

Chromatin dynamics control the timescales of essential biological processes including DNA damage repair and activation of gene promoters by distal enhancers. Prior chromatin dynamics studies have repo...

biorxiv.org

matteomazzocca.bsky.social@matteomazzocca.bsky.social · last yr.

1/ Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)

Forget liquid-liquid phase separation, here comes solid phase transition 😱 www.nature.com/articles/s41...

Solid phase transitions as a solution to the genome folding paradox - Nature

In vitro reconstitution and in vivo live-cell imaging of LHX2–EBF1–LDB1 enhancer hubs in olfactory sensory neurons reveals that these transcription factors form condensates with solid, rathe...

nature.com

Hiro's paper is out! @hiro-cg5445.bsky.social Collaboration and Tour de Force with Richard Wheeler @zephyris-science.bsky.social and many other coauthors. Big congratulations and thank you to anyone involved! www.nature.com/articles/s41...

Small-molecule dissolution of stress granules by redox modulation benefits ALS models - Nature Chemical Biology

Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...

nature.com

👏new paper👏 ! Our preprint is now accepted at MBoC @ascbiology.bsky.social Congrats to co-1st authors Junnan (new PI at OSU!) and Weiyi (now a Yale grad student) and 🙏 to collaborators Melissa & Jordan @myosincity.bsky.social Funded by NIH grants & NSF GRFP! www.biorxiv.org/content/10.1...

The PCM scaffold enables RNA localization to centrosomes

As microtubule-organizing centers, centrosomes direct assembly of the bipolar mitotic spindle required for chromosome segregation and genome stability. Centrosome activity requires the dynamic assembl...

biorxiv.org

I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. www.cell.com/cell/fulltex....

RNA xkcd.com/3056

Excited to announce the newest member of the flock - STARLING (conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models). www.biorxiv.org/content/10.1...