Excited to share our work at @natcomms.nature.com We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq. SCP will revolutionise immunology, this is just the start

Alejandro Brenes@ajbrenes.com · last yr.

Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value

Our most recent work entitled “Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity” is now published. Well done @mas-g.bsky.social. rdcu.be/eM5MT

Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity

Nature Immunology - Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in...

rdcu.be

Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma https://www.biorxiv.org/content/10.1101/2025.07.23.666094v1

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) www.nature.com/articles/s41...

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature

Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

nature.com

Did you ever wonder why metastatic cancers often spread to the lungs? Amazing research from @ginevradoglioni.bsky.social! Many thanks to all collaborators, funders and patients. Wishing you all an enjoyable read and a happy new year and Ginevra a great next endeavor @salkinstitute.bsky.social

Ginevra Doglioni@ginevradoglioni.bsky.social · 2y ago

Beyond excited to share that the main work of my PhD on how aspartate signaling drives metastasis is finally out in @nature.com ✨ -> go.nature.com/4gCYtuL A huge thank to the @fendtlab.bsky.social and all our collaborators for the terrific team work 🙏 A brief 🧵

#InterferonPower! Khan Tran Divanghai &co show @natimmunol.bsky.social that systemic fungal b-glucan administration potentates granulopoieis via type I IFNs (not IL1!) driving IL10-producing neutrophils that protect against lung influenza A virus infection increasing immune tolerance, not resistance

β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus - Nature Immunology

Divangahi and colleagues report that β-glucan pretreatment before influenza A virus challenge can increase survival by inducing long-term reprogramming of neutrophils, promoting disease tolerance irre...

nature.com