New research from Peter Mac has uncovered further evidence of how pregnancy triggers a powerful, long-lasting immune response in the breast, opening the door to potential new ways to prevent #breastcancer in people at high risk. Read more: petermac.org/about-us/new...

Massive congratulations to @ajithvasanthan.bsky.social, @t-hussain.bsky.social, and everyone else involved. An equally amazing and important discovery.

Ajith Vasanthakumar@ajithvasanthan.bsky.social · last mo.

I’m excited to share our latest study, published today in @natimmunol.nature.com. It is long known that pregnancy reduces the risk of developing breast cancer, yet the biological mechanisms underlying this protection have remained largely unknown. Read the paper here: www.nature.com/articles/s41...

I’m excited to share our latest study, published today in @natimmunol.nature.com. It is long known that pregnancy reduces the risk of developing breast cancer, yet the biological mechanisms underlying this protection have remained largely unknown. Read the paper here: www.nature.com/articles/s41...

Pregnancy-induced tissue-resident memory-like T cells contribute to tumor control in breast cancer - Nature Immunology

Here the authors identify an abundance of a tissue-resident memory-like T cell population in the breasts of women who have given birth. These cells can contribute to tumor control and may thereby prov...

nature.com

This has been a great collaboration between @ajithvasanthan.bsky.social lab and mine @wehi-research.bsky.social led by Sara Quon and Adelynn Tang! Thanks to @elife.bsky.social editors and peer reviewers for the constructive process!

Excited to share the final version of our paper with @ajithvasanthan.bsky.social @petermaccc.bsky.social on the gene we discovered, Dreg1 @elife.bsky.social Here we probe a novel knockout to identity a specific role for Dreg1 in group 2 ILC development elifesciences.org/articles/109...

Pleased to collaborate with @rhyscienceallan.bsky.social @wehi-research.bsky.social on this exciting study exploring the function of the lncRNA Dreg1, published in @elife.bsky.social. We found that Dreg1 is critical for ILC2 development. @petermaccc.bsky.social elifesciences.org/reviewed-pre...

Excited to start the new year with our collaborative paper with @ajithvasanthan.bsky.social being published @elife.bsky.social -check it out! elifesciences.org/reviewed-pre...

Rhys Allan@rhyscienceallan.bsky.social · 11mo ago

I am excited to share our latest study by Sara Quon in collaboration with @ajithvasanthan.bsky.social entitled “The lncRNA Dreg1 is required for optimal ILC2 development” www.biorxiv.org/content/10.1...

A very fast moving area: we now have more post-CDK4/6 options than clear biological principles for choosing among them. Looking forward to discussing this at #SABCS25 @sabcs.bsky.social @elmayermd.bsky.social

San Antonio Breast Cancer Symposium@sabcs.bsky.social · 10mo ago

After CDK4/6 Inhibitors: Advancing Treatment for HR+HER2-negative Metastatic Breast Cancer— Mafalda Oliveira, Erica Mayer, and Shom Goel will address this topic in an educational session at #SABCS25 (December 9-12). Learn more: buff.ly/0YYiXTa

Maternal IgG transfer and neonatal infection synergize via Fc receptor pathways to promote allergic TH2 immunity @sciimmunology.bsky.social www.science.org/doi/10.1126/...

Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells @natimmunol.nature.com @yuripritykin.bsky.social Rudensky @princetonupress.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...

Thrilled to make the cover of @natimmunol.nature.com this month. A version of this warhol-inspired image has been in my head almost since we first conceived this Tfh diversity project (many, many years ago) @wehi-research.bsky.social

Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability @sciimmunology.bsky.social www.science.org/doi/10.1126/...

Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate

Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability.

science.org

I am excited to share our latest study by Sara Quon in collaboration with @ajithvasanthan.bsky.social entitled “The lncRNA Dreg1 is required for optimal ILC2 development” www.biorxiv.org/content/10.1...

The long non-coding RNA Dreg1 is required for optimal ILC2 development

Gata3 is an essential transcription factor for the development of several distinct immune cell lineages such as T cells, natural killer (NK) cells and innate lymphoid cells (ILC). As such, the levels ...

biorxiv.org

NR4A2 & RGS16 promoters support delivery of cytokines (e.g. IL-12) directly to the tumor site, leading to enhanced antitumor efficacy and long-term survival of mice in both syngeneic and xenogeneic models @nature.com @paulbeavis4.bsky.social www.nature.com/articles/s41...

Australia completely lacks a dedicated training program for clinician scientists. With the vision and support of VMIAL @petermaccc.bsky.social is extremely proud to announce the first clinician-scientist fellowship. If you meet the eligibility criteria PLEASE APPLY! www.nature.com/naturecareer...

Clinician Scientist Fellowship - Parkville, Melbourne (AU) job with Peter MacCallum Cancer Centre – Parkville | 12839522

Peter Mac is launching Australia’s first clinician-scientist fellowship to advance cancer care, fostering innovation and global collaboration.

nature.com

I am so excited to share our new publication on Nature Metabolism about the metabolic reprogramming in gamma delta T cells in response to inflammation. #gdt #immunometabolism Thanks for my research team in groups of @timsparwasser.bsky.social in Germany and Princeton @lydialynch.bsky.social 🙌🏻

Nature Metabolism@natmetabolism.nature.com · last yr.

CCR8+ decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy | Science Immunology www.science.org/doi/10.1126/...

CCR8+ decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy

Decidual CCR8+ dTreg cells, with a highly activated and immunosuppressive phenotype, are crucial for maternal-fetal immune tolerance.

science.org

Our paper is out! LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...

LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity

LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.

science.org

Someone awesome in my circle shared some terrific news with me today but was hesitant to do so because of all that is going on in the science world. It may appear insensitive that you are celebrating when other colleagues are struggling but I entreat you to celebrate & share good news. 1/

If any American immunologists want to write an op-ed for @immunolcellbiol.bsky.social on the impact of the new executive orders, please contact me

www.forbes.com/sites/roncar...

One More Time: Why Diversity Leads To Better Team Performance

Discussions on diversity in the workplace can be heated and contentious. But the data still shows more diverse teams outperform their less diverse peers. Here's how.

forbes.com

Very excited about this collaborative study between @petermaccc.bsky.social @danielutzschneider.bsky.social and Kallies lab

Daniel Utzschneider@danielutzschneider.bsky.social · 2y ago

Excited for our lab's FIRST paper #ScienceImmunology! 🎉 Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social Huge thanks to reviewers & @claireolingy.bsky.social 🙌 #Tpex #onthescoreboard www.science.org/doi/full/10....

Cool new study from the lab of my friend and collaborator @danielutzschneider.bsky.social in #ScienceImmunology showing that a common ID3+ precursor gives rise to stem-like memory and Tpex cells. Congrats to everyone involved!! @rickyjohnstone.bsky.social @petermaccc.bsky.social @onjcri.org.au

Daniel Utzschneider@danielutzschneider.bsky.social · 2y ago

Excited for our lab's FIRST paper #ScienceImmunology! 🎉 Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social Huge thanks to reviewers & @claireolingy.bsky.social 🙌 #Tpex #onthescoreboard www.science.org/doi/full/10....

@ozsinglecell.bsky.social #OzSingleCell25 has a new website www.ozsinglecell.com See the current list of invited speakers and stay tuned for registration details. Sponsors reach out to ozsinglecells@gmail.com

Exciting new study from the Mathis group showing the features and functions of meningeal Tregs now in Science Immunology!!@https://www.science.org/doi/10.1126/sciimmunol.adu2910n

The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis

Meningeal regulatory T cells restrain local interferon-γ–producing lymphocytes, thereby safeguarding parenchymal brain homeostasis.

science.org

Tour de force! @metorrespadilla.bsky.social & team develop Smart-seq+5′ to map TSS in single embryos with unprecedented res revealing plethora of TE-driven transcripts in 5 mammal species. Some surprisingly old & conserved. Treasure trove of new biology for yrs to come! www.cell.com/cell/fulltex...

An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development

Mapping transcription start sites across five mammalian species before, during, and after embryonic genome activation unveils widespread transposable element-driven transcription and co-option of evol...

cell.com

Interested in how T cells are regulated in a tissue-specific manner? Karthik Varanasi’s exciting work shows Bile Acid synthesis impedes tumor-specific T cell responses during liver cancer @science.org Huge THANKS to all the amazing collaborators + @salkinstitute, SBP www.science.org/doi/10.1126/...

Bile acid synthesis impedes tumor-specific T cell responses during liver cancer

The metabolic landscape of cancer greatly influences antitumor immunity, yet it remains unclear how organ-specific metabolites in the tumor microenvironment influence immunosurveillance. We found that...

science.org

Here is link to Shixin's new paper: www.science.org/doi/epdf/10....

Nutrient-driven histone code determines exhausted CD8+ T cell fates

ACLY-deficient CAR T cells targeting the tumor-associated antigen disialoganglioside GD2 (GD2 CAR T cells) also resisted acquiring TEX-like properties, exhibiting reduced CD39 expression when co-cultu...

science.org

The fate of T cells, such as seen in exhausted T cells, is tied to nutrients. This introduces the potential of therapies directed at keeping T cell identity and function intact. (And the infamous Krebs cycle makes a comeback to my brain) www.science.org/doi/10.1126/...

Nutrient-driven histone code determines exhausted CD8+ T cell fates

ACLY-deficient CAR T cells targeting the tumor-associated antigen disialoganglioside GD2 (GD2 CAR T cells) also resisted acquiring TEX-like properties, exhibiting reduced CD39 expression when co-cultu...

science.org

Jobortunities: Shortly advertising for 2 positions, both working on the Breast Cancer Atlas, in Sydney. - Wet lab research assistant: mol bio +/- pathology desirable - Comp. Research Assistant: scRNA-Seq, spatial transcriptomics and ML Details to follow, DM or email if you are a great fit.