To mark World #Malaria Day, here are 2 recent Science #Immunology papers highlighting cutting-edge malaria research! Nideffer & al. (2025) scim.ag/4izhn63 Gao & al. (2025) scim.ag/4hN5vOY

Spatial TCR profiling has the potential answers to key questions in cancer immunology, including revealing spatially coordinated T cell states in head and neck cancer @sciimmunology.bsky.social www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... @bcmfromthelabs.bsky.social

Excited to share our work published yesterday (and featured on the cover!) of #ScienceImmunology. This was a true team effort between the Reizis lab at NYU @uchicagocoi.bsky.social and Sasha Galitsyna & Leonid Mirny at MIT 1/ www.science.org/doi/10.1126/...

Very happy to see this published! 🎉🎉🎉 Amazing collaboration with Max Yun and her team @maxyunlab.bsky.social @crtd-tud.bsky.social on Axolotl Thymus regeneration. Thanks also to @claireolingy.bsky.social for coverage, and grateful for December cover #scienceimmunology www.science.org/doi/10.1126/...

Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl

The molecular, cellular, and functional restoration of the axolotl thymus after de novo regeneration is described.

science.org

David Baker & colleagues develop an #IL21 mimic (21h10) that is more stable & shows x-reactivity against both human & murine #IL21R. 21h10 promotes potent antitumor responses in mice and in human #melanoma tumor explants, expanding low-affinity CD8 #TCells & #TH1 cells & reducing #Tregs in #tumors!

Design of a potent interleukin-21 mimic for cancer immunotherapy

A de novo IL-21 mimic, 21h10, exhibits improved stability and potent antitumor activity in vivo compared with native IL-21.

science.org

Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!

Nuclear polarization to the immune synapse facilitates an early transcriptional burst

Cytotoxic T lymphocyte target recognition triggers rapid nuclear polarization to the immune synapse and an early transcriptional burst of cytokines.

science.org

Looking forward to a great meeting next week! Email or DM me if you would like to chat!

@emds2025.bsky.social · 11mo ago

📣 Journal Editors at #EMDS2025 @claireolingy.bsky.social , Senior Editor at #Science #Immunology @aaas.org , will be at EMDS2025, so be sure to reach out to her to discuss your work. @efis-immunology.bsky.social @britsocimm.bsky.social

The August issue of #Science #Immunology is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid #arthritis; vagal TRPV1+ sensory #neurons protect against #influenza virus infection; & transfer of #Tregs alleviates #inflammaging in mice! wwwscience.org/toc/sciimmun...

The July issue of #Science #Immunology is out now! This week: • Additional levels of #IL13RA1 gene regulation help explain susceptibility to #allergy! • Spi-B is a #checkpoint of #type2 immunity by restraining #TuftCell activation in gut! New content each week! www.science.org/toc/sciimmun...

This month in #Science #Immunology, Shivangi Dave & André Ballesteros Tato at the #NIH review the noncanonical contributions of #TFollicularHelper ( #TFH ) cells cells to immune regulation beyond their traditional roles in #BCell help! science.org/doi/10.1126/sciimmunol.adr1052

The June issue of #Science #Immunology has launched! This week: inducible #FoxP3 degradation in #Tregs; the immune landscape of human #psoriatic #arthritis; & #IL12 gives #mRNA #vaccines a boost! New content every week! Check it out! www.science.org/toc/sciimmun...

This month in #Science #Immunology: @nickmroz.bsky.social, @phagocyticpai.bsky.social, @annamolofskylab.bsky.social, & @arimolofskylab.bsky.social pen an insightful & timely Review on crosstalk between the #nervous system & #type2 immunity! #WeekendRead #neuroimmunology #allergy #Alzheimers #itch

Cross-regulation between the nervous system and type 2 immunity

The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters, suggesting previously unidentified therapeutic avenues.

science.org

This is a public service announcement: late-breaking abstract submissions for #IUIS2025 will close tomorrow (May 6)! You can submit your abstracts here: iuis2025.org/abstracts/ I hope to see many of you this August in beautiful Vienna!!! #Immunology #Science2025 #CallForAbstracts #IUIS

Abstracts - IUIS 2025

ABSTRACTS ALL ABOUT SUBMISSION IMPORTANT INFORMATION LATE ABSTRACT SUBMISSION IS NOW OPEN guidelines LATE ABSTRACT SUBMISSION GUIDELINES Important Dates 20 November 2024 – Abstract Submission Opens 25...

iuis2025.org

The May issue of #Science #Immunology is out now! This week: #interferon regulates #thymic epithelial cell differentiation; #efferocytosis determines #alveolar #macrophage functional plasticity: & mapping the #stromal cell landscape of human #LymphNodes! science.org/toc/sciimmunol/10/107

Happy Int'l #DayofImmunology! To celebrate, here are some recent Reviews from the pages of #Science #Immunology!!! First up: Kumagai, Momoi, & Nishikawa survey recent literature on links between #cancer genetic abnormalities & #immunosuppression that cause clinical resistance to #immunotherapy!

Immunogenomic cancer evolution: A framework to understand cancer immunosuppression

Understanding the impacts of genetic abnormalities on immune responses to tumors can inform immunogenomic-based precision medicine.

science.org

On #WorldMalariaDay, check out this brand new study on human T cell memory responses to #malaria from the lab of Pras Jagannathan at Stanford! 🦟🩸 www.science.org/doi/10.1126/...

Clone tracking through repeated malaria identifies high-fidelity memory CD4 T cell responses

Expanded CD4+ T cell clones preferentially adopt a single fate in malaria, and TR1 cells dominate and display long-term memory.

science.org

A new #ScienceImmunology study in mice suggests that bacterial skin infections can imprint eosinophils with innate immune memory and enhance allergic inflammation in the lungs.

Eosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammation

Staphylococcus aureus skin infection induces eosinophil innate immune memory to exacerbate allergen-induced airway inflammation.

scim.ag

#Immunology out now @science.org After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen. buff.ly/49bKcTG By Jobin, Seetharama, Rüttger et al.

The April issue of #Science #Immunology is out now! This past week: two papers describe how #skin #inflammation can drive #type2 immune responses in other #mucosal tissues, while a third describes how #hunger perception in the #brain regulates peripheral immune cell dynamics! Check it out!

Science Magazine@science.org · last yr.

In #ScienceImmunology, researchers describe how #hunger perception in the brain can mimic the effects of #fasting and alter circulating immune cell levels. Read about this study and more: scim.ag/4j3gx2A

1/ Excited to share my first-ever first-author paper out now in Science Immunology! from @knapplab.bsky.social and co-supervised by @miershawig.bsky.social We show that hematopoietic aging, independent of lung tissue aging, is sufficient to exacerbate fibrosis. 🔗 www.science.org/doi/10.1126/...

An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence

Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10.

science.org

#Bluetorial: In our latest paper on #gdTcells and #IBD in #ScienceImmunology we found that γδ IEL number and regulatory function are severely compromised BEFORE ileal inflammation occurs, suggesting that γδ IELs may maintain IEL homeostasis in response to a pro-inflammatory microenvironment. 1/n

two men are riding a bicycle with a basket on it .

ALT: two men are riding a bicycle with a basket on it .

media.tenor.com

We are thrilled to share our new manuscript @science.org , in which we uncovers a critical role for macrophage peroxisomes in lung repair after viral infection. Could targeting peroxisomes be the key to mitigating long COVID?! www.science.org/doi/10.1126/...

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae

Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...

science.org

To celebrate with the @keystonesymposia.bsky.social #myeloid cell meeting happening now in Hannover, we have released a free collection of 6 recent #Science #Immunology papers focused on myeloid cells! Check 'em out! They will be available until the end of April! bit.ly/SciImm_free #KSmyeloid25

To commemorate #RareDiseaseDay, here are some recent #Science #Immunology research papers that elucidate the immune mechanisms underlying certain rare human diseases and/or report new strategies to treat them! @science.org

This week in #Science #Immunology: A comprehensive review from Darrell Irvine and co-authors on recent advances in understanding #vaccine #adjuvant mechanisms of action, which could guide adjuvant design for vaccines against emerging and challenging pathogens:

Linking vaccine adjuvant mechanisms of action to function

We review mechanisms of action underlying the function of vaccine adjuvants and knowledge gaps to be addressed.

science.org

My editorial on the indirect cuts. This is an opportunity for campuses to come together to make the case for higher education. Leaders need to step up and ask for support and lead. www.science.org/doi/10.1126/...

A direct hit

Late last week, the Trump administration set off a frenzy in the US scientific community when the National Institutes of Health (NIH) announced that indirect cost reimbursement for federally funded re...

science.org

Timely study by Katherine Kedzierska and Jamie Rossjohn and colleagues defining key structural features of #Tcell binding to circulating #influenza strains from 1918 to ~present #ImmunoSky www.science.org/doi/10.1126/...

Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors

TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants.

science.org

Now out in #Science #Immunology (and also featured on the cover!): Lutz, @simonhaas.bsky.social, Weinhold, & al. use single-cell and spatial multiomics to characterize breakout lesions in #multiplemyeloma, identifying regions of immune and tumor cell coevolution:

Bone marrow breakout lesions act as key sites for tumor-immune cell diversification in multiple myeloma

Single-cell and spatial multiomics analyses identify breakout lesions as a hotspot for tumor-immune interactions and diversification.

science.org

I’ll be here (joint with T cell Differentiation in Tissue Microenvironments) next week! Send me a message or email if you’d like to set up a time to chat. Looking forward to an exciting meeting!

Keystone Symposia@keystonesymposia.bsky.social · 2y ago

Catch @drshrutinaik.bsky.social, @labfairfax.bsky.social, @ostunilab.bsky.social and Yasmine Belkaid for Innate Immune Memory. Submit your abstract for a poster presentation spot by Jan. 9th (11:59pm MST)! keysym.us/KSInnateImmu... #KSInnateImmune25 #keystoneconferences #innateimmunity

1/ New in #ScienceImmunologyResearch! We explored how the brain maintains equilibrium with the immune system. Our focus? The key player in immune tolerance and tissue function regulation: regulatory T cells (Tregs). Let’s dive in! www.science.org/doi/10.1126/... @immunoeditor.bsky.social

The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis

Meningeal regulatory T cells restrain local interferon-γ–producing lymphocytes, thereby safeguarding parenchymal brain homeostasis.

science.org