This looks cool!

Alejandro Montenegro@aemonten.bsky.social · 10h ago

"Here, we introduce POND-seq (protein nanocage-empowered non-destructive sequencing), a strategy that employs secretory protein nanocages fused to RNA-binding proteins (RBPs) to recover RBP-associated RNAs from living cells" www.cell.com/molecular-ce...

Canada has a ton of helium, but not a single commercial scale liquefaction plant. It all goes to the US and we buy it back at a x1000 what we sold it for. Same with every other resource. Fix that @mark-carney.bsky.social

Brad Postle@bradpostle.bsky.social · 2d ago

Aarabi, M.H. Neuroimaging runs on helium, helium runs through Hormuz. Nat Neurosci 29, 1777–1778 (2026). doi.org/10.1038/s415...

Our latest contribution on #regulatoryevolution in which we show that the shape of fitness functions and the distribution of mutational effect sizes jointly limit adaptation by regulatory mutations. Led by @simonaube.bsky.social www.nature.com/articles/s41...

The shape of fitness functions and the distribution of mutational effect sizes jointly limit adaptation by regulatory mutations - Nature Ecology & Evolution

Saturation mutagenesis of the FCY1 promoter in budding yeast shows that adaptation to 5-fluorocytosine is not accessible through single cis-regulatory mutations, despite large mutational effects on pr...

nature.com

LINE-1 and antibody diversification! #EverythingIsLINE1related

Hiten Madhani@hitenmadhani.bsky.social · 2d ago

H3K9me2/3 strikes again! This time in B cells. The latest from the Basu lab at Columbia. www.cell.com/cell/fulltex...

A multivalent RNA affinity tag enables selective purification of tagged RNAs and bound proteins doi.org/10.1093/nar/...

A multivalent RNA affinity tag enables selective purification of tagged RNAs and bound proteins

Abstract. Efficient purification of specific RNAs from lysates remains a major challenge. Existing methods, such as MS2 tagging or oligonucleotide hybridiz

doi.org

I just heard about the term “Intellectual Omnivore” and I feel seen… #YupThatsMe

Inefablejuly Dog Eats Cereal and Bread

ALT: Inefablejuly Dog Eats Cereal and Bread

static.klipy.com

Yet another #zebrafish genome update: We just updated our ZebrafishGenomics public datahub for the UCSC browser (available all the way at the bottom here: genome.ucsc.edu/cgi-bin/hgHu...). We added several useful tracks including:

Something tells me ... this is a big deal #Transposons #Evolution #Sex-linkedDisease #LINE1

Di Jiang@dijiang319.bsky.social · 6d ago

Why is the X chromosome rich in L1 mobile elements? @science.org X-chromosome inactivation draws L1 mutagenesis to the human X chromosome | Science www.science.org/doi/10.1126/...

New research just dropped today that makes octopuses even weirder than they already are… let me explain🧵🧪🐙🐡🦑

That is ADHD… #IYKYK

Diedrich Bader@diedrichbader.bsky.social · 6d ago

Masculinity is funny to me sometimes This guy driving a cab yellow Maserati is loudly revving his engine in traffic to let everyone know how fast he would go if we weren’t holding him back

PSA - 👇

Emily Johnston@enjohnston.bsky.social · last wk.

You know what this ISN'T? An LLM. Once more for the folks in the back: nearly all of the actually useful, genuinely promising things that AI can do for us have nothing to do with LLMs & planet-devouring data centers. Hope, not hype. Serving us, not serving us up to Big Tech. @sciam.bsky.social

This is equal parts fascinating and crazy! Biology is wild.

Jeff Groh@jeffgroh.bsky.social · last wk.

Avocados come in 2 varieties - A-types start each day female and switch to male midday. B-types do the reverse. In work just published from the last chapter of my PhD, we show this system evolved 40+million yrs ago and is regulated by alleles of 1 transcription factor www.pnas.org/doi/10.1073/...

Jim Shorter and his postdoc Miriam wrote a beautiful preview about our most recent paper on mRNAs preventing misfolding of IDR-containing proteins. UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins: Cell www.cell.com/cell/fulltex...

UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins

How do cells ensure that complex, multidomain proteins fold correctly? Luo et al. reveal a self-contained solution. The 3′UTR of an mRNA co-translationally chaperones the protein it encodes, preventin...

cell.com

And we thought forest fires were only bad in Canada this year. 220,000 people evacuated in France!

Castanet.net@castanet.net · last wk.

France says monster fire that forced 220,000 people to flee has stopped growing #France

So… there is a new and fast spreading sexually transmitted diseases and it is not bacterial or viral, it is fungal and related to ring worm! 😳😬 www.instagram.com/reel/DXSusee...

Dr. Andi on Instagram: "There’s a new STI being talked about in the U.S. and it’s not a virus or bacteria… it’s a fungus. TMVII is an emerging type of ringworm that can spread through close skin-to-s...

12K likes, 403 comments - your.doctor.bestie on April 18, 2026: "There’s a new STI being talked about in the U.S. and it’s not a virus or bacteria… it’s a fungus. TMVII is an emerging type of ringwor...

instagram.com

Lots of food for thought in this thread … #AIandScience

Jase Gehring@skyjase.bsky.social · last wk.

for a very large number of reasons, this should not be your concern, especially at this point in time

100%

Max Fawcett@maxfawcett.bsky.social · 2w ago

Alberta hasn't banned US alcohol imports. People here aren't buying it anyways. The debate over whether provincial governments should be banning it misses the actual point, which is that Canadians don't want to buy it in the first place. #cdnpoli

Ahhh… #PerfectWeatherForaBikeRide #PointPleasant #Halifax

Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch www.science.org/doi/10.1126/...

Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch

Mammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell ...

science.org

New work from Wikramanayake & Martindale Labs suggests ancestral β-catenin-binding motif-like sequence in Axin-RGS acquired weak β-catenin-binding capacity in early-emerging metazoans.... In bilaterians, a duplicated motif evolved higher-affinity for β-catenin, while the ancestral sequence was lost.

Reconstructing the evolutionary origin of β-catenin recognition in the Wnt destruction complex

Abstract. Emergence of Wnt/β-catenin signaling was a major metazoan innovation, yet how its core molecular interactions evolved remains unresolved. Here, w

academic.oup.com

Back to the future moment… In the 80s this was pretty common, as most schools had swimming programs vis community pools (remember the badges for swimming and diving!?) and access to CPR training.

Castanet.net@castanet.net · 2w ago

Poll: Should the B.C. government mandate basic water survival skills in school?

I guarantee this Instagram post will trigger either imposter syndrome or incredible FOMO in most academic Ph.D.’s 😬😳 www.instagram.com/reel/DbNHLDZ...

Very cool new resource for this unusual eukaryote

American Society for Cell Biology@ascbiology.bsky.social · 2w ago

From MBoC A new localization atlas maps more than 600 Giardia proteins, revealing the locations of hundreds of previously uncharacterized proteins and creating a valuable resource for functional discovery. https://www.molbiolcell.org/doi/10.1091/mbc.E25-12-0590

This is why AI needs wet lab... #ThereIsaidIt

Lennart Hilbert@lennarthilbert.bsky.social · 2w ago

A periodic reminder for all of our convenience: “The data are not good or bad. The data are the data.” “Data is king.” “Without data, all theory is crap.” 3 sentences I learned from 3 supervisors AKA the reason it’s worth spending 1/3 of my time and 2/3 of our budget on keeping a wet lab running.

4D Nucleome special issue of Science, featuring our paper "Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor", led by Zoe Grant in my lab and Zhuzhen Kuang in Katie Pollard's lab @gladstoneinst.bsky.social www.science.org/toc/science/...

Yet another example of a contagious cancer! Inter-individual transmission of melanoma in catfish! www.cbc.ca/news/science...

'Rare' contagious cancer found in fish from Quebec and U.S. lakes | CBC News

It's rare that cancerous tumours can spread from one individual to another. But a genetic study suggests that's what's happening with melanoma skin cancer tumours among catfish in Quebec and the north...

cbc.ca

In case you missed this Cancer Discovery paper in the news last week: First-in-Human Testing of a Mutant KRAS Vaccine for Pancreatic Cancer Interception in High-Risk Cohorts - by Daniel Haldar, Amanda Huff, Michael Goggins, Elizabeth Jaffee, Neeha Zaidi, and colleagues @aacrjournals.bsky.social

American Association for Cancer Research (AACR)@theaacr.bsky.social · 3w ago

A vaccine to intercept pancreatic cancer in high-risk individuals was safe and elicited specific and durable immune responses, according to research published in the AACR journal Cancer Discovery. Learn more: www.aacr.org/about-the-aa...

Man pulls gun over a pool noodle in West Kelowna BC - #FAFO delivered by local shortly afterwards

Castanet.net@castanet.net · 2w ago

West Kelowna man says he disarmed a gunman by pool Saturday #WestKelowna

And also the loss of the Buffalo 🦬 contributed to the dust bowl droughts of the 1930s. Ironically, the 60 yr culling of buffalo to ostensibly cut off a major food source for American Indigenous peoples of the Great Plains, resulted in near starvation conditions for settlers 50 years later.

Jessica Kant@jessdkant.bsky.social · 2w ago

A lot of people don’t realize the dust bowl wasn’t a natural phenomenon. It happened when agrobusiness interests dramatically transformed the plains without regard for drought, and created vicious dust storms that choked whole families to death. That’s what I think of when I read about data centers.

#Healthcare is one of the top Three priorities for the federal government according to the latest Abacus poll. Part two - respondents think the federal Liberal party is the best party to solve healthcare problems.