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Alyssa Johnson

@alyssajohnson.bsky.social

Associate Professor at LSU using worms and flies to study lysosomes, aging, and age-related diseases. Lab website: https://faculty.lsu.edu/johnsona/index.php

25 Posts1153 Follower961 Folgt
@lsuresearch.bsky.social · 5mo ago

"When chance brought a lone crustacean to [an LSU] scientist’s car park in the USA, he had an unusual response: try to get an exceptionally detailed 3D scan of the animal." - BBC Wildlife Magazine discoverwildlife.com/animal-facts... @lsu.bsky.social

"I believe it may have fallen from someone’s grocery bag.” Scientist finds unlikely creature in US parking lot – and only has one thing on his mind... | Discover Wildlife

The microscopy expert put the big-clawed animal through his micro-CT scanner, creating an incredibly detailed image of its body.

discoverwildlife.com

@lsuresearch.bsky.social · 5mo ago

Enjoy this animation of sleep neurons in a fruit fly... and while you are at it, did you know fruit flies are teaching us how some people can get by with 4-5 hours of sleep every night just fine?! It has to do with a genetic variant that boosts mitochondrial function! www.lsu.edu/blog/2026/03...

Alyssa Johnson@alyssajohnson.bsky.social · 9mo ago

In our newest paper published in @natcomms.nature.com, we show that DAF-16/FOXO and HLH-30/TFRB promote healthy aging, in part, by activating lipid metabolism genes that remodel lysosomes into tubular networks (more in comments below). www.nature.com/articles/s41...

DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegans - Nature Communications

This study reveals that transcription factors DAF-16/FOXO and HLH-30/TFEB promote healthy aging in C. elegans, in part, by activating lipid metabolism genes that remodel lysosomes into tubular network...

nature.com

Cahir O'Kane@cahirokane.bsky.social · last yr.

This is a useful distinction - generative vs non-generative AI for writing, and how it relates to the writer's own input

Prof Julia Steinberger 🌹🌱🌍 #ClimateAction #Fightfascism@jksteinberger.bsky.social · last yr.

As promised, here are the slides I shared with students to convince them to NOT use chatGPT and other artificial stupidity. TL;DR? AI is evil, unsustainable and stupid, and I'd much rather they use their own brains, make their own mistakes, and actually learn something. 🪄

Alyssa Johnson@alyssajohnson.bsky.social · 2y ago

Some good news amidst all the chaos…New paper published in Biology Open! This work was initiated by two undergraduates (Brennan Mercola and Tatiana Villalobos) and completed by graduate students Jocelyn Wood and Ankita Basu! @biologyopen.bsky.social @lsuscience.bsky.social @lsuresearch.bsky.social

Increased expression of the small lysosomal gene SVIP in the Drosophila gut suppresses pathophysiological features associated with a high-fat diet

Summary: Increasing lysosome activity in the fly midgut offsets negative effects of an obesogenic high-fat diet.

journals.biologists.com

Jalees Rehman@jalees.bsky.social · 2y ago

Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans www.cell.com/cell-metabol...

Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans

Hahn et al. report the presence of 6mA, a DNA modification, on the mitochondrial (mt)DNA of various animal and plant species. Modulating the activity of 6mA enzymatic modifiers implicates 6mA in regulating mtDNA replication and expression and the transmission of mtDNA mutations across generations, ultimately affecting mitochondrial health and organismal lifespan.

cell.com

Women in Autophagy@womeninautophagy.bsky.social · 2y ago

#PaperAlert we bring wonderful news about @WAutophagy ... our Mericka McCabe and our founders just published a @NatureCellBio article explaining the wonders of our Network...don't miss a bit!! With very valuables testimonials of our volunteers... rdcu.be/d10N6

Women in Autophagy: an initiative to promote gender parity in science

Nature Cell Biology - Scientific questions are universal but the scientific workforce remains skewed, with women and gender minorities still underrepresented. Initiatives such as the Women in...

rdcu.be

Coleen Murphy@ctmurphy1.bsky.social · 2y ago

My first Bluesky paper post! I’m pleased to announce the publication of our single-nucleus atlas of adult neurons from wild-type and long-lived, better performing insulin receptor (daf-2) mutants, by Jon St. Ange and Yifei Weng et al.DOI: 10.1016/j.xgen.2024.100720

Nikolay Kukushkin@niko-kukushkin.bsky.social · 2y ago

Hi! I study how cells form memories. Our lab's most recent study in Nature Commmunications shows that non-neural cells, including kidney cells, can count, detect precise time patterns, and form lasting memories in ways similar to neurons.🧵https://www.nature.com/articles/s41467-024-53922-x

William Mair@willmair.bsky.social · 2y ago

Cool new work from the lab by @chris-morrow.bsky.social: Often we think of auto-fluorescence as a hindrance to experiments - but endogenous metabolites have specific fluorescence we can use to determine the metabolic state of the cell - and predict lifespan.. www.nature.com/articles/s42...

Endogenous mitochondrial NAD(P)H fluorescence can predict lifespan - Communications Biology

Endogenous mitochondrial NAD(P)H fluorescence enables label-free and subcellular resolution quantification of aging, prediction of remaining lifespan and tracking of age-dependent changes to mitochond...

nature.com