Nuclear mechanobiology: a brief history and five unresolved questions

Published in Nucleus (Vol. 17, No. 1, 2026)

tandfonline.com

Liberalism’s Cult of the Individual Has Failed Us

America is suffering from a complete breakdown in social life and shared conception of the common good. Some prominent liberals want to keep it that way.

jacobin.com

Lysine pyruvylation couples glycolytic flux to epigenetic regulation - Nature Metabolism

The recently identified post-translational modification lysine pyruvylation modulates gene expression, thereby directly linking glycolytic flux to chromatin-based transcriptional regulation.

dlvr.it

First human trials of designer protein therapies stun US neuroscientists

Chinese researchers are testing DREADDs, a gene therapy to turn down neuronal activity, in the clinic

cen.acs.org

Artificial hibernation reveals synaptic engram architecture associated with memory retention

Memories leave lasting physical changes at the synaptic level. Although stable, larger spines are thought to support memory, the high turnover of dendritic spines and the drifting of neuronal represen...

scim.ag

A practical toolbox for modelling fibrosis in vitro

Nature Biomedical Engineering, Published online: 13 August 2026; doi:10.1038/s41551-026-01749-wKey tissue features shared by fibrotic diseases are distilled into clear design rules for human in vitro models, with practical guidance on choosing cells, matrices and platforms for mechanistic studies and drug testing.

go.nature.com

The Tantalizing Possibility Of Locating Consciousness In The Brain | NOEMA

Few discoveries would be more consequential than identifying the specific neural structures responsible for subjective experience.

noemamag.com

If AOC Doesn’t Run for President, Run a Union Worker

The Left can’t sit out the 2028 Democratic primary. If AOC chooses not to run for president, Eric Blanc argues that socialists should run a working-class candidate — even an unknown one — who can inject anti-billionaire politics into the race.

jacobin.com

Schwayer Lab

The mammalian liver possesses a regenerative capacity that is unmatched by any other organ. Following injury, liver epithelial cells can proliferate or even change their identity, enabling the organ t...

mdc-berlin.de

A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin

The metabolite α-ketoglutarate (αKG) is required for chromatin demethylation, but mechanisms that control αKG abundance in the nucleus are poorly defined. We designed a biosensor to monitor this metab...

science.org

Pyruvate leaves its mark on chromatin

Nature Metabolism, Published online: 03 July 2026; doi:10.1038/s42255-026-01561-5Lysine pyruvylation, a newly discovered histone modification installed by HAT1 and p300 and removed by SIRT3, connects the glycolytic metabolite pyruvate to transcriptional regulation, shedding light on metabolism–epigenetics crosstalk.

dlvr.it

Nobel-winning chemist leaves US to direct AI materials lab in China

Omar Yaghi’s move comes amid cuts to US science and a campaign in China to recruit top international talent.

go.nature.com

Rewiring tumour mechanosensing to overcome CAR T cell resistance

Nature Biomedical Engineering, Published online: 06 July 2026; doi:10.1038/s41551-026-01731-6A genetic circuit sensing microenvironment softness-induced calcium signalling can be rewired to express a synthetic antigen, boosting chimeric antigen receptor (CAR) T cell killing of stem-like tumour cells.

go.nature.com

When The Machines Deserve Our Consideration | NOEMA

We will never know for sure if AI can be conscious. A neuroscientist argues that we shouldn’t wait for proof to decide how to treat it.

noemamag.com

Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning

During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

cell.com

Sensory nerves protect against tendon degeneration

Nature Reviews Rheumatology, Published online: 29 June 2026; doi:10.1038/s41584-026-01398-yFindings indicate that sensory neuron-derived proteins regulate tendon repair and have a protective role in chronic tendinopathy.

dlvr.it

Why the Human Genome’s Tangled Physicality May Confound AI | Quanta Magazine

Our genetic heritage is not a blueprint or an algorithm, as many biologists have imagined, but something else entirely.

quantamagazine.org

Resetting of epigenetic cold memory through somatic embryogenesis in plant regeneration - Nature Plants

This study shows that the epigenetic cold memory or ‘vernalized state’ in overwintering plants can be reset through somatic embryogenesis, overturning the long-standing idea that the vernalized state ...

nature.com

The senescence-stiffening loop: Extracellular matrix remodeling, hypoperfusion, and mitochondrial dysfunction drive tissue aging

Stiffening of the extracellular matrix, declining microvascular perfusion, and mitochondrial dysfunction reinforce one another to drive tissue aging. This perspective outlines a unifying matrix-vascular-metabolic axis and highlights potential entry points to preserve tissue resilience and function with age.

dlvr.it

Epigenetic programming by H3K23ac defines lineage fate of Meg3+ haematopoietic stem cells and drives immune ageing - Nature Cell Biology

Wei et al. show that Meg3+ haematopoietic stem cells (HSCs) expand upon ageing and present with an increase in H3K23ac levels observed already at middle age. Inhibiting H3K23ac ameliorates megakaryocy...

nature.com