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Ani Deshpande Lab

@anideshpande.bsky.social

Assoc. Prof. at SBP, La Jolla. Epigenetics, Pediatric Cancers, Leukemia, Stem Cells. LinkedIn: http://tinyurl.com/4yn4tj98

77 Posts247 Follower543 Folgt
Ani Deshpande Lab@anideshpande.bsky.social · last yr.

I’m excited to share that as of July 1, I’ve been promoted to Full Professor. I am immensely grateful for the support of my trainees, mentors, letter writers and colleagues who supported me in reaching this milestone and for those who made this journey meaningful and worthwhile.

euanashley@euanashley.bsky.social · last yr.

Atul Butte died yesterday. The world lost a giant. A big bear of a man. With a huge smile. With love for everyone. With energy that could power a room. I loved everything about Atul. I loved how he was always happy. I loved how excited he was about science and helping people.

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Harmit Singh Malik@harmitmalik.bsky.social · last yr.

We live in such a golden age of science with so much potential for discovery and alleviating some of the most severe human diseases. And we are going to piss it all away because … I’m not exactly sure why. No one has made a convincing case why this helps anyone, red or blue or purple.

allen institute@alleninstitute.org · last yr.

We've launched the Armamentarium, a new toolkit for targeted gene delivery to the brain and spinal cord. This #OpenScience resource was made possible thanks to support from the NIH BRAIN Initiative and teamwork with our collaborators. 🧠📈 www.nih.gov/news-events/...

Ian Bogost@ibogost.com · last yr.

As someone who covered both: -NIH cuts came first; there is some news exhaustion; - “Curing cancer” is an easier story to tell than the varied domains funded by NSF, and easier for citizens to find applicable; - You’re not going to like this, but people don’t know what “science” is.

Jacob T. Levy@jacobtlevy.bsky.social · last yr.

I know NIH is ~5x bigger than NSF but I think the gutting of NSF is getting a lot less than 1/5 the attention— in the news media and in higher ed— compared with what's happened to NIH.

Dr. Glaucomflecken@glaucomflecken.bsky.social · last yr.

I’m fascinated by scientific breakthroughs that were universally hailed in the moment, like pasteurization, that are now vilified by some people. Is this a uniquely American thing? Anybody written a book about why/how this happens? Like the psychology behind it. I’d love to learn more.

Elizabeth Jacobs, PhD@elizabethjacobs.bsky.social · last yr.

Ben Franklin on inoculation, after his son died from smallpox. “In 1736, I lost one of my sons, a fine boy of four years old, by the small-pox, taken in the common way. I long regretted bitterly, and still regret that I had not given it to him by inoculation”.

Jo Wolff@jowolff.bsky.social · last yr.

Every now again it’s useful to repeat advice about accessing papers that are behind a paywall that excludes you. Email the author. My estimate is that 90% of academics are so thrilled that a living, breathing, possibly even reading, person shows interest that they will swiftly send you a copy.

Ani Deshpande Lab@anideshpande.bsky.social · last yr.

In Episode 2 of the Discovery Dialogues Podcast, we recount the fascinating story of the race to clone the first human gene. Featuring Herb Boyer and Keiichi Itakura. 🎥YouTube: tinyurl.com/4x7fkzzu 🎧 Spotify: tinyurl.com/3af8zrt8 🎧 Apple Podcasts: tinyurl.com/2st95bb9

E2 Diabetes The Race for Human Insulin

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

tinyurl.com

Arjun Raj@arjunraj.bsky.social · last yr.

I feel like the conference talk format has gotten so stale, even for those who are good at it. How can we switch it up? One idea we've been toying with is an "interview" style, where after a 5 minute presentation, an interviewer who has read the paper engages in a structured conversation. Thoughts?

Eric Topol@erictopol.bsky.social · last yr.

Genome editing success for the first time in nine patients with alpha-1 antitrypsin deficiency, a heritable disease which can cause cirrhosis and emphysema, affecting ~100,000 Americans, which is similar to the prevalence of sickle cell disease www.nytimes.com/2025/03/10/h...

Mutated DNA Restored to Normal in Gene Therapy Advance

The small study in patients with a rare disorder that causes liver and lung damage showed the potential for precisely targeted infusions.

nytimes.com

Fyodor Urnov@urnov.bsky.social · last yr.

This would have never, ever-ever been done by a for-profit entity. At the time this was way too experimental - only an "academic" team could have taken on this risk. pubmed.ncbi.nlm.nih.gov/23527958/

Chimeric antigen receptor-modified T cells for acute lymphoid leukemia - PubMed

Chimeric antigen receptor-modified T cells with specificity for CD19 have shown promise in the treatment of chronic lymphocytic leukemia (CLL). It remains to be established whether chimeric antigen re...

pubmed.ncbi.nlm.nih.gov

Ani Deshpande Lab@anideshpande.bsky.social · last yr.

There are thousands of studies published on the cancer-causing protein MYC – but some big pieces of the puzzle have been missing. I am excited to share a preprint of one of the coolest studies I have seen go from inception to completion from my colleague Anindya Bagchi's Lab. tinyurl.com/447f2jur

Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements

MYC-driven (MYC+) cancers are aggressive and often fatal. MYC dysregulation is a key event in these cancers, but overexpression of MYC alone is not always enough to cause cancer. Plasmocytoma Variant ...

tinyurl.com