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Fleur Ferguson

@fleurmferguson.bsky.social

Assistant Professor, UCSD. Induced proximity, medicinal chemistry, chemical proteomics. https://fergusonlab.ucsd.edu

7 Posts1007 Follower261 Folgt
IUPAC@iupac.org · 11mo ago

‼️ Call for Nominations🏅Chi-Huey Wong Chemical Biology Award 1️⃣ Official Nomination Form 2️⃣ Nomination Letter (maximum 1,000 words) 🙅 Self-nominations will not be considered 📅 Nominate before October 31, 2025 👉 Ms. Marene Chan 📧 jccs@gate.sinica.edu.tw 🌐 chemistry.org.tw/award_chwong/

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Fleur Ferguson@fleurmferguson.bsky.social · 12mo ago

Excited to share our latest work developing molecular glue degraders of ZBTB11, now out in @natchembio.nature.com www.nature.com/articles/s41...

ZBTB11 depletion targets metabolic vulnerabilities in KRAS inhibitor-resistant PDAC - Nature Chemical Biology

Depletion of a transcriptional factor ZBTB11 using molecular glue degraders can overcome oxidative-phosphorylation-mediated KRAS inhibitor resistance in pancreatic ductal adenocarcinoma with low acute...

nature.com

Michael Erb@michael-erb.bsky.social · last yr.

New work out today introducing PCIPs, heterobifunctional chemical inducers of proximity that inhibit DNA repair by recruiting BET proteins to PARP2. Great work uncovering a new form of event-driven pharmacology by Bryce/Eric/Erin and the rest of the team. (1/3) www.biorxiv.org/content/10.1...

Rewiring DNA repair with PARP-based chemical inducers of proximity

Chemical inducers of proximity (CIPs) can elicit durable, and often neomorphic, biological effects through the formation of a ternary complex, even at low equilibrium occupancy of their targets. This ...

biorxiv.org

Milka Kostic@milkakostic.bsky.social · last yr.

We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology! careers.dana-farber.org/job/11813/as...

Faculty/Health Educator Job: Assistant/Associate Professor, Chemical Biology at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA

Assistant/Associate Professor, Chemical Biology job

careers.dana-farber.org

Behnam Nabet@behnamnabet.bsky.social · last yr.

🚨 New preprint! Excited to share our latest work, led by @sauravk05.bsky.social (Nabet lab) and Jiewei Jiang (Ferguson‬ lab), on targeting oncogenic TRK fusions. We report potent and selective degraders of TPM3-TRKA, a driver of adult and pediatric cancers. www.biorxiv.org/content/10.1...

Development of PROTACs for targeted degradation of oncogenic TRK fusions

Chromosomal translocations leading to the fusion of tropomyosin receptor kinases (TRK) with diverse partner proteins have been identified as oncogenic drivers in many adult and pediatric cancers. Whil...

biorxiv.org

Zhi Lindsey Lin@zhilindseylin.bsky.social · last yr.

Really enjoyed this proximity-based therapeutics keystone conference! Appreciate the organizers Fleur @fleurmferguson.bsky.social and Phil for the opportunity and for putting together this wonderful event!

Keystone Symposia@keystonesymposia.bsky.social · last yr.

Celebrate the scholarship winners from Proximity-Based Therapeutics: Markella Konstantinidou, @zhilindseylin.bsky.social, Charlene Mae Magtoto, Ashwini Premashankar, & Maximilian R. Stammnitz. Learn more about financial aid at keysym.us/KSFinancialAid. #keystonesymposia #keystoneconferences

Danette Daniels@danetteldaniels.bsky.social · 2y ago

Congratulations to both of you! @WomeninTPD first official scholarship award winners ☺️

Women in TPD & Induced Proximity@womenintpd.bsky.social · 2y ago

Congratulations to @alesalerno.bsky.social from University of Dundee CeTPD and Christine Ng from @stanford-chemh.bsky.social who have been selected as recipients of our conference travel scholarships to attend the Proximity-based Therapeutics Keystone conference @keystonesymposia.bsky.social!

Nature Chemical Biology@natchembio.nature.com · 2y ago

We asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most needed developments in your main field of research?” You can read that they said in our Feature “Thoughts for the future” – Free to read in January. rdcu.be/d5Ksw

Thoughts for the future

Nature Chemical Biology - As Nature Chemical Biology approaches its third decade we asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most...

rdcu.be

Women in TPD & Induced Proximity@womenintpd.bsky.social · 2y ago

Here is the link for the Keystone Conference: www.keystonesymposia.org/conferences/... Thank you to the organizers @fleurmferguson.bsky.social and Phil Chamberlain for helping us coordinate and setup this opportunity.

Proximity-Based Therapeutics: Targeted Protein Degradation and Other Pharmacological Approaches | Keystone Symposia

Join us at the Keystone Symposia on Proximity-Based Therapeutics: Targeted Protein Degradation and Other Pharmacological Approaches, February 2025, in Santa Fe, with field leaders!

keystonesymposia.org

Fleur Ferguson@fleurmferguson.bsky.social · 2y ago

Excited to share our work investigating how ligand residence time influences targeted protein degradation outcomes at scale, and how we can combine kinetic scout degrader approaches with mathematical modeling to accelerate hit finding and optimization! onlinelibrary.wiley.com/doi/abs/10.1...

A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development

Bifunctional molecules such as targeted protein degraders induce proximity to promote gain-of-function pharmacology. These powerful approaches have gained broad traction across academia and the pharm....

onlinelibrary.wiley.com